Marijuana and thromboembolic events in geriatric trauma patients: The cannabinoids clots correlation!

Asmar, Samer; Nelson, Adam; Anand, Tanya; Hammad, Ahmed Mohammed Ali; Obaid, Omar; Ditillo, Michael; Saljuqi, Abdul Tawab; Tang, Andrew; Joseph, Bellal

doi:10.1016/j.amjsurg.2021.07.036

Cited by 10 publications

(3 citation statements)

References 21 publications

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“…Using a similar approach to study the impact of THC exposure on TEC in geriatric trauma patients (age > 65 years), researchers found that the rate of TEC was significantly higher in THC(+ve) geriatric trauma patients compared to THC(−ve) group (3.0% vs. 1.7%; p = 0.01). Furthermore, the THC(+ve) group had significantly higher rates of DVT (2.2% vs. 0.6%, p < 0.01) and PE (1.4% vs. 0.4%, p < 0.01) in comparison to control THC(−ve) patients [62].…”

Section: Procoagulatory Effects Of Cannabinoidsmentioning

confidence: 86%

The Endocannabinoid System: A Potential Therapeutic Target for Coagulopathies

Khayat

Lehmann

2022

Metabolites

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Abnormal blood coagulation or coagulopathy is a common manifestation of many pathological conditions. It occurs when there is an imbalance between the activities of the coagulation system and the fibrinolytic system, leading to excessive or impaired intravascular blood clot formation, which can disturb blood flow causing ischemia or hemorrhage in the affected tissues. A growing body of evidence has demonstrated blood coagulation abnormalities in association with cannabinoid use, suggesting the involvement of the endogenous cannabinoid system (ECS) in modulating blood coagulation. However, the evidence in the literature has been controversial on whether cannabinoids promote or inhibit blood coagulation. The ECS has been extensively studied in recent years for its potential as a therapeutic target for many diseases. This review provides a brief introduction to the ECS and discusses the reported anticoagulatory and procoagulatory effects of various cannabinoids, highlighting some possible mechanisms that might underlie the observed effects. Understanding the coagulatory effects of cannabinoids and the interaction between the coagulation system and the ECS is vital for developing novel therapeutics for coagulopathies.

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Section: Procoagulatory Effects Of Cannabinoidsmentioning

confidence: 86%

The Endocannabinoid System: A Potential Therapeutic Target for Coagulopathies

Khayat

Lehmann

2022

Metabolites

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“…Similar symptoms (dizziness, lightheadedness, dry mouth) have been reported in older Canadian 16 and Israeli 17 adults using medicinal marijuana. In chart review studies, marijuana use among older patients has been associated with psychiatric, respiratory, cardiovascular, and neurologic conditions 18,19 . Cross‐sectional data from observational studies suggest that older people who use marijuana may have more behavioral symptoms and reduced cognitive performance 20,21 .…”

Section: Introductionmentioning

confidence: 99%

“…In chart review studies, marijuana use among older patients has been associated with psychiatric, respiratory, cardiovascular, and neurologic conditions. 18 , 19 Cross-sectional data from observational studies suggest that older people who use marijuana may have more behavioral symptoms and reduced cognitive performance. 20 , 21 Health care providers cannot turn to data from RCTs to inform patients about the risks and benefits of marijuana use, but observational data suggest that older people who use marijuana may have a higher risk profile than those who abstain.…”

Section: Introductionmentioning

confidence: 99%

Marijuana use among community‐dwelling older adults: A population‐based study

De Genna,

Jacobsen,

Ganguli

2024

Int J Geriat Psychiatry

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ObjectivesThere is a paucity of population‐level data on marijuana use and mental health and functioning in older adults.MethodsWe analyzed cross‐sectional data (n = 910) from a well‐characterized cohort, the Monongahela‐Youghiogheny Healthy Aging Team (MYHAT) study. MYHAT is an age‐stratified random sample of the population age 65 years and older from a small‐town in the USA. Half the sample was female and half were over 75 (Mean age = 77). Most participants were non‐Hispanic White. Marijuana use was assessed by self‐report and symptoms of mood disorders were screened using the modified Centers for Epidemiological Studies‐Depression Scale and the Generalized Anxiety Disorder screener. Cognition was assessed by the Mini‐Mental State Examination and a neuropsychological test battery; functioning using the OARS Activities of Daily Living and Instrumental Activities of Daily Living; and overall assessment using the Clinical Dementia Rating (CDR®).ResultsOne in five MYHAT participants had a history of marijuana use and 5% reported recent use, primarily for pain (41%) and recreation/relaxation (37%). Recent use was associated with cigarette and alcohol use, symptoms of depression or anxiety, and impairments in attention.ConclusionsTwenty‐percent of community‐dwelling older adults living in a US state where recreational marijuana use is illegal had a history of marijuana use. Recent marijuana use was less common but, consistent with prior research, associated with other substance use and poorer mental health.

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