This article explores a major contributory factor to the perennial, literary import of María de Zayas's novellas: her innovative portrayal of friendship amongst women. Throughout Zayas's second prose work, the Desengaños amorosos (1647), nascent female solidarity emerges in tandem with the disenchantment that pervades her depiction of relations between the sexes. Considerable critical attention has been directed towards the question of Zayas's Spanish proto-feminism; studies that examine this issue have an impoverishing tendency to under-explore her texts' same-sex relationships and to confi ne their fi eld of study to hetero-relations. To address this analytical dearth, I will examine the emergent friendship trajectory of the autobiographical novella narrated by Isabel, a determinative protagonist who is introduced in the Desengaños amorosos, and the interweaving of narrative levels that results from her crucial solidarity with the principal frame protagonist, Lisis. Thus, I detect in Zayas's prose an early example of what Janice Raymond has since termed 'Gyn/affection'. By contrasting the burgeoning Gyn/affection among Zayas's female protagonists with representations of friendship in other seventeenth-century Spanish works, including female-authored comedias, the original appeal of her novelistic endeavour becomes manifest.Much critical interest in Zayas's novellas has centred on celebrating her status as a Golden-Age proto-feminist or, in contrast, moderating or refuting this claim by debating the appropriateness of such chronocentric analyses.1 If we continue to descend into this critical mire, a hazard presents itself: by focussing exclusively upon her portrayal of relationships between the sexes, we devalue Zayas's prose by marginalizing the multifarious aspects that have assured her enduring appeal. I intend to examine one such aspect, Zayas's portrayal of the potency of female friendship, with particular reference to Zelima/Isabel, Zayas's only autobiographical narrator. By discussing Zelima's narrative and through exploration of its interrelationship with the frame, I will uncover innovative and perennially appealing qualities of Zayas's prose, which are vividly exposed in the light of her literary context. An intriguing shift in tone follows the ten-year hiatus between the publication of Zayas's two prose texts, in 1637 and 1647.2 As the title of her second collection would suggest,