Margins in extra‐abdominal desmoid tumors: A comparative analysis

Leithner, Andreas; Gapp, Markus; Leithner, Katharina; Radl, Roman; Krippl, Peter; Beham, Alfred; Windhager, Reinhard

doi:10.1002/jso.20057

Cited by 57 publications

(30 citation statements)

References 50 publications

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“…A relatively critical comparative analysis by Leithner et al [19] concluded that wide or radical excision was the treatment of choice. In our series, positive margin was an independent prognostic factor that significantly influenced LR in the multivariate analysis (11% negative vs. 42% positive).…”

Section: Journal Of Surgical Oncologymentioning

confidence: 99%

Prognostic factors for extra‐abdominal and abdominal wall desmoids: A 20‐year experience at a single institution

Huang

Shi

et al. 2009

Journal of Surgical Oncology

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Section: Journal Of Surgical Oncologymentioning

confidence: 99%

Prognostic factors for extra‐abdominal and abdominal wall desmoids: A 20‐year experience at a single institution

Huang

Shi

et al. 2009

Journal of Surgical Oncology

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“…One retrospective analysis of the literature collected for desmoid tumors in all locations found that local control rates for DTs with positive surgical margins were 41%, compared with local control rates of 72% for DTs with negative surgical margins (mean followup time 10.4 years) [18]. Similarly, another retrospective analysis of the literature collected for extra-abdominal DTs found that 72% of patients with a marginal or intralesional excision according to the Enneking classification system had a recurrence, compared with only 27% of patients who had wide or aggressive microscopic surgical margins [16].…”

Section: Resultsmentioning

confidence: 99%

“…Although the post-surgical recurrence rate is high, with up to 72% of patients experiencing recurrence, surgical resection with wide or aggressive margins has been shown to reduce the recurrent rate [16]. Several studies suggest that cases in which wide or aggressive margins cannot be achieved, adjuvant radiotherapy may decrease recurrence rates [9,17,18].…”

Section: Introductionmentioning

confidence: 99%

Aggressive Resection of Cervical Desmoid Tumor Invading the Paraspinal Muscles without Recurrence at Eight Year Followup: A Case Report and Review of the Literature

Eichberg¹,

Urakov²,

Vanni³

2017

Clin Med Rev Case Rep

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Objective: To provide an overview of head, neck, and spine Desmoid Tumor (DT), to describe the case of a patient who underwent aggressive surgical resection of a large invasive cervical DT, and to analyze the DT literature. We discuss the importance of aggressive surgical margins in decreasing recurrence risk in head, neck, and spine DTs. Methods:A twenty-three-year-old female patient with history of a left cervical neurofibroma resection presented two years later with neck mass regrowth. The mass was aggressively resected, and occiput to T1 fusion was performed. Additionally, the head, neck, and spine DT literature was reviewed regarding surgical margin status and recurrence rate. A "N-1" Chi-squared test was used to compare proportions, between percentage of patients that experienced recurrence after gross total resection, and percentage of patients that experienced recurrence after subtotal resection, to determine statistical significance (p < 0.05).Results: Histologically, the lesion was shown to be a DT, with posterior paracervical spinal musculature invasion. The surgery was well tolerated with no complications. At eight years postoperative followup, the patient is doing well with no tumor recurrence. Nine studies were identified describing surgical margin status and recurrence rate of head, neck, and spine DT. When recurrence rates were compared in patients with grossly negative surgical margins and grossly positive surgical margins for head, neck, and spine DTs, two studies showed statistical significance (p < 0.05) for lower recurrence rate after gross total resection, and seven showed a trend toward lower recurrence rates in patients with gross total resection. Conclusion:DTs are difficult clinical entities to cure due to high recurrence rate after resection. Consistent with previous studies indicating that aggressive surgical margins are associated with a decreased risk of recurrence, we present a case report of a female patient who underwent aggressive resection of a large DT and remains tumor-free after eight years. Thus, we recommend aggressive surgical resection of head, neck, and spine DTs to minimize recurrence risk.

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“…Posner et al [20] ont réalisé une analyse multivariée sur 138 patients avec des tumeurs desmoïdes intra-et extra-abdominales, primaires ou récidivantes, et montrèrent que les marges de résection sur l'examen histologique étaient le principal facteur de récidive locale. De même, Leithner et al [11], en 2004, dans leur revue de la littérature sur l'importance des marges de résection retrouvaient qu'après une résection intralésionnelle ou contaminée histologiquement, le taux de récidive est très élevé avec 72 % de récidive contre 27 % après une résection chirurgicale radicale ou large. De même, des résultats similaires ont été retrouvés par Goy et al [7] [18], à travers une revue de 22 articles, montraient que les marges de résections n'avaient pas une importance notable, mais l'auteur avait mélangé les tumeurs desmoïdes intra-et extra-abdominales, donc ses résultats sont peu interpréta-bles.…”

Section: Facteurs Prédisposant à La Récidiveunclassified

Traitement chirurgical dans les tumeurs desmoïdes extra-abdominales: analyse critique d’une série de 36 patients opérés

et al. 2010

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Desmoid fibromatoses are a rare benign tumour but with a high rate of local recidivism. The goal of this article was to identify the prognostic factor and to evaluate the efficacy of the surgery. We report 36 patients who underwent surgery in our department between 1989 and 2008. Twentyfour had recidivism. This tumour primarily affects women in the third or fourth decade. The principal prognostic factor is the margin of resection. MRI seems to be useful to predict the potential of recidivism. The role of the surgery remains to be determined, and therapeutic indication must to be discussed with regard to benefits and risks. Also, the "wait and see" attitude must be evaluated as this tumour stabilizes spontaneously. To cite this journal: Oncologie 13 (2011).

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Margins in extra‐abdominal desmoid tumors: A comparative analysis

Cited by 57 publications

References 50 publications

Prognostic factors for extra‐abdominal and abdominal wall desmoids: A 20‐year experience at a single institution

Prognostic factors for extra‐abdominal and abdominal wall desmoids: A 20‐year experience at a single institution

Aggressive Resection of Cervical Desmoid Tumor Invading the Paraspinal Muscles without Recurrence at Eight Year Followup: A Case Report and Review of the Literature

Traitement chirurgical dans les tumeurs desmoïdes extra-abdominales: analyse critique d’une série de 36 patients opérés

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