Marginal zone B-cell lymphomas of different sites share similar cytogenetic and morphologic features [see comments]

Abstract

Clinical, histologic, cytogenetic, and molecular genetic data of 31 patients with extranodal, nodal, and splenic marginal zone B-cell lymphoma (MZBCL) are presented. Despite these variable clinical manifestations, a similar spectrum of morphologic features as well as distinctive immunophenotypic findings were noted. In all cases, a monotypic B-cell proliferation consistently negative for CD5, CD10, and CD23 was found expanding the marginal zone of the B follicle with and without colonization of the follicle centers. Clonal chromosomal abnormalities were detected in 23 of the 31 patients. Recurrent aberrations included whole or partial trisomy 3 (18 cases), trisomy 18 (9 cases), and structural rearrangements of chromosome 1 with breakpoints in 1q21 (9 cases) or 1p34 (6 cases), all of which were seen in extranodal, nodal, as well as splenic MZBCL. Abnormalities of the additional chromosome 3, such as +del(3)(p13),+i(3)(q10), or structural changes involving the distal part of the long arm, were evident in 9 of the 18 cases. All recurrent abnormalities were found in MZBCL more frequently than in other histologic entities of B-cell non-Hodgkin's lymphoma (B-NHL). None of the known lymphoma-associated chromosomal changes or rearrangements of the BCL1, BCL2, BCL3, BCL6, and CMYC genes were detected. We conclude that MZBCL represent a distinct entity of B- NHL with characteristic morphologic and immunophenotypic features and particular chromosomal abnormalities, and that a close histogenetic relationship between extranodal, nodal, and splenic MZBCL is likely, although the clinical presentation may vary.

Clinicopathologic characteristics and treatment of marginal zone lymphoma of mucosa‐associated lymphoid tissue (MALT lymphoma)

“…52 In addition, numerical aberrations, ie, trisomy 7, 12, and 18, have been reported, as have structural changes located on chromosome 1. 51,53,54 In cases transforming to diffuse large B-cell lymphoma, c-myc rearrangements and complete or partial inactivation of p53 have been reported. 55 Other common karyotypic alterations characteristic of MALT lymphomas include the translocations t(11;18)(q21;q21), t(1;14)(p22;q32), t(14;18) (q32;q21), t(3;14)(q27;q32), and t(3;14)(p14.1;q32).…”

The bendamustine plus rituximab regimen is active against primary nodal marginal zone B‐cell lymphoma

“…Some studies report that NMZL is associated with hepatitis C . No specific cytogenetic abnormalities have been identified, and most of those reported can be found in other lymphoproliferative diseases, in particular, gains on chromosomes 3 and 18.…”

Trisomy 3 in two paediatric post‐transplant lymphomas

“…Trisomy 3 has been observed in MALT and MZBL lymphomas in different locations, such as splenic, gastric and salivary glands (Solé et al, 1997;Zhang et al, 1998;Ihrler et al, 2000). Dierlamm et al (1996a) postulated that because of their similar morphology, immunophenotype and cytogenetic findings (high incidence of trisomy 3), nodal, extranodal and splenic MZBL (SMZBL) are different manifestations of the same entity. Most reports in the literature deal with the splenic type (SMZBL) in which the occurrence of trisomy 3, using conventional karyotyping and FISH, varies from 18% to 85% in different series (Wotherspoon et al, 1995;Brynes et al, 1996;Dierlamm et al, 1996b;Solé et al, 1997;Blanco et al, 1999).…”