Marginal zone B cell lymphomas with extensive plasmacytic differentiation are neoplasms of precursor plasma cells

Meyerson, Howard; Bailey, Jeffrey A.; Miedler, John D.; Olobatuyi, Felix

doi:10.1002/cyto.b.20571

Cited by 11 publications

(14 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The current WHO-classification of Tumors of Hematopoietic and Lymphoid Tissue 2017 [6] classifies localized plasmacytic-differentiated B cell lymphoproliferations (e.g., in the skin, in the stomach, and in the salivary glands) as plasmacytic-differentiated marginal zone lymphomas, presupposing that a small B cell component is detectable within the biopsy specimen. Some authors claim that plasmacyticdifferentiated marginal zone lymphomas have to be classified as pure plasma cell neoplasms, because they exhibit the immunophenotype of plasma cells rather than the immunophenotype of mature B cells in flow cytometry analysis [20]. The question whether a relatively small B cell component in localized amyloidosis is part of the neoplastic clone or not is currently unknown, and the classification of a lymphoproliferation associated with localized AL amyloidosis is an unsolved issue.…”

Section: Discussionmentioning

confidence: 99%

AL amyloidosis with a localized B cell neoplasia

et al. 2019

View full text Add to dashboard Cite

Immunoglobulin light chain-derived (AL) amyloidosis may occur as a systemic disease usually with dismal prognosis and a localized variant with favorable outcome. We report 29 patients with AL amyloidosis and associated lymphoplasmacytic infiltrate spatially related to amyloid deposits. In 17 cases, the amyloid deposits were classified as ALλ and 12 as ALκ Histopathology in all cases showed relatively sparse plasma cells and B cells without tumor or sheet formation by the lymphoplasmacytic infiltrate. The B cells predominantly showed an immunophenotype of the marginal zone. In situ, hybridization revealed 17 cases with λ− and 10 with κ light chain restricted plasma cells, which was concordant with the AL subtype in each case. Clonal immunoglobulin heavy variable gene (IGHV) or κ light chain rearrangement was found in 23/29 interpretable cases. A single case harbored a MYD88 L265P-mutation. Taken together, we detected 27 (93%) cases of AL amyloidosis with an associated light chain restricted and predominantly molecularly clonal plasma cell population. Clinical data were available in 18 patients. Five patients suffered from systemic lymphoma and two from systemic AL amyloidosis. The remaining cases were classified as localized with regard to both, the AL amyloidosis and the light chain restricted plasma cell population. To the best of our knowledge, we herein present the largest cohort of AL amyloidosis associated with a light chain restricted and predominantly molecularly clonal plasma cell population, which we designate as a distinct disease entity: BAL amyloidosis with a localized B cell neoplasia of undetermined significance^.

show abstract

Section: Discussionmentioning

confidence: 99%

AL amyloidosis with a localized B cell neoplasia

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The phenomenon of the lack of CD138 expression in malignant plasma cells of MZL with plasmacytic differentiation has been described previously [ 13 , 14 ]. In our case, morphologically mature malignant plasma cells (Marschalko type) in the intervening cords also exhibited an aberrant plasma cell-related antigen profile.…”

Section: Discussionmentioning

confidence: 85%

Simultaneous Occurrence of Rosai–Dorfman Disease and Nodal Marginal Zone Lymphoma in a Patient with Sjögren’s Syndrome

Gorodetskiy

Klapper

Пробатова

et al. 2018

Case Reports in Hematology

View full text Add to dashboard Cite

We present an exceptionally rare case of co-occurrence of Rosai–Dorfman disease (RDD) and nodal marginal zone lymphoma (NMZL) in a 60-year-old Caucasian female with a 20-year course of Sjögren's syndrome (SS). In response to treatment for lymphoma, the patient presented a short positive response, followed by a rapid progression of the disease accompanied by the development of the peripheral facial nerve palsy. We failed to detect Epstein–Barr virus (EBV) in the NMZL/RDD sample by EBV-encoded RNA (EBER) in situ hybridization but identified genomic DNA of EBV by polymerase chain reaction. A second biopsy revealed EBV-positive diffuse large B-cell lymphoma (DLBCL), not otherwise specified. The identical clonal immunoglobulin heavy chain gene rearrangements in the NMZL and DLBCL pointed to their clonal relationship. Though the role of EBV in the pathogenesis of some lymphomas is well-known, there have been only few cases of EBV-induced transformation of low-grade B-cell lymphoma into high-grade lymphoma and no cases of a patient with an NMZL background. To our knowledge, this is the first report of a concomitant occurrence of RDD and NMZL in a SS patient.

show abstract

“…Several authors have noted that the distinction between plasmacytoma and MALT lymphoma with plasma cell differentiation is sometimes ambiguous [ 8 , 15 ]. Meanwhile, Meyerson et al investigated both diseases and related disorders by using flow cytometric analysis and described that plasma cells observed in marginal zone lymphoma resembled normal precursor plasma cells, whereas those observed in plasma cell myeloma were similar to more mature marrow plasma cells [ 16 ]. Regardless of the pathogeneses of the two diseases, the similarities in the endoscopic images observed in the present case and the case of plasmacytoma reported by Harada et al [ 6 ] may reflect common pathological features shared between the two cases, for example, proliferation of plasma cells.…”

Section: Discussionmentioning

confidence: 99%

Gastric MALT Lymphoma with Increased Plasma Cell Differentiation Showing Unique Endoscopic Features

Iwamuro

Tanaka

Nishida

et al. 2018

Case Reports in Gastrointestinal Medicine

View full text Add to dashboard Cite

A 62-year-old woman was diagnosed with extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) with increased plasma cell differentiation of the stomach. Esophagogastroduodenoscopy showed slightly elevated, whitish lesions in the gastric body. Magnifying endoscopic observation revealed that the gastric surface epithelium was swollen, but the structure was not destroyed or diminished. Elongated, tortuous vasculature was observed on the surface of the whitish lesions. The patient underwent eradication treatment for Helicobacter pylori, which resulted in complete remission. Although the appearance of abnormal vessels and the destruction of gastric epithelial structure are the typical features of gastric MALT lymphoma during magnifying endoscopy, the present case showed different features, which were rather similar to those observed in a previously reported case of gastric plasmacytoma. The current case indicates that magnifying endoscopic features are not uniform among gastric MALT lymphomas.

show abstract

Marginal zone B cell lymphomas with extensive plasmacytic differentiation are neoplasms of precursor plasma cells

Abstract: Occasional marginal zone lymphomas have extensive plasmacytic differentiation (P-MZL). We present an argument based on our data and previous published observations that P-MZL represent neoplasms of precursor plasma cells.

Cited by 11 publications

References 41 publications

AL amyloidosis with a localized B cell neoplasia

AL amyloidosis with a localized B cell neoplasia

Simultaneous Occurrence of Rosai–Dorfman Disease and Nodal Marginal Zone Lymphoma in a Patient with Sjögren’s Syndrome

Gastric MALT Lymphoma with Increased Plasma Cell Differentiation Showing Unique Endoscopic Features

Contact Info

Product

Resources

About