Marginal zone B-cell lymphoma involving a longstanding fibrous meningioma: an initial manifestation of systemic disease

Martin, Sarah E.; Khalidi, Hasan S.; Hattab, Eyas M.

doi:10.1016/j.humpath.2013.04.016

Cited by 9 publications

(11 citation statements)

References 13 publications

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“…Two of the cases were discovered at autopsy, 10 were simultaneous presentation, four had diagnosis of lymphoma after a meningioma, and one had a history of lymphoma before development of meningioma (minimum 2 months-maximum 5 years delayed). [2][3][4][5][6][7][8][9][10] Present case is a 44-year-old woman, with contiguous tumors at the same dural site. She had no previous imaging studies to determine whether one lesion was present before the other, but her clinical symptoms were headache and paresis, not systemic lymphoma-related symptoms.…”

Section: Discussionmentioning

confidence: 95%

“…[1] Some hypotheses have are the intracranial tumors more often associated with meningiomas. [1] The combined presence of intracranial meningioma and lymphoma is exceptionally rare with only 17 cases reported in the literature [1][2][3][4][5][6][7][8][9][10] [ Table 1]. Most of the patients are woman with a mean age of 64.2 (38-80 years).…”

Section: Discussionmentioning

confidence: 99%

“…Intracranial lymphoma is a relatively rare disease accounts for approximately 1% of all intracranial tumors. [3,4] Most primary intracranial lymphomas are high-grade diffuse large B-cell lymphomas, but most been suggested such as locally acting oncogenic factor or an irritative effect of a tumor inducing the growth of other neoplasm, to explain the presence of different multiple primary intracranial tumors in patients without predisposing factors. Meningioma, one of the most common intracranial tumors, is the most commonly reported tumor in association with other intracranial neoplasms due to its slow growth.…”

Section: Discussionmentioning

confidence: 99%

“…Low-grade lymphomas are less common, show dural attachment and mimic a menengioma radiographically. [3,4] Immunodeficiency and Epstein-Barr virus has been…”

Section: Introductionmentioning

confidence: 99%

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Coexistence of intracranial marginal zone B-cell lymphoma and meningioma: Case report and review of the literature

Çakır¹,

Yıldırım²,

Küçük³

et al. 2017

IJNS

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Synchronous presentation of multiple primary central nervous system tumors is extremely rare. Meningioma is the most commonly reported tumor in association with other intracranial neoplasms. Review of the literature revealed only 17 cases of meningiomas co-existing with intracranial lymphomas. A 44-year-old woman presented with headache and facial paresis. Magnetic resonance imaging revealed intracranial dural-epidural right frontal mass with tumor extension into the overlying calvarium. A right frontotemporal craniotomy and tumor resection was performed. Histopathologic examination showed a composite meningioma and marginal zone B-cell lymphoma. Radiographic, laboratory, and bone marrow examinations failed to reveal any evidence of systemic disease. Of the 17 lymphoma patients associated with meningioma, two were mucosa-associated lymphoid tissue type but both of these tumors were systemic metastases to intracranial meningiomas. Present report is the first case of a primary intracranial marginal zone B-cell lymphoma interdigitated with a fibroblastic type meningioma.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Low-grade lymphomas are less common, show dural attachment and mimic a menengioma radiographically. [3,4] Immunodeficiency and Epstein-Barr virus has been…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Coexistence of intracranial marginal zone B-cell lymphoma and meningioma: Case report and review of the literature

Çakır¹,

Yıldırım²,

Küçük³

et al. 2017

IJNS

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“…Aho et al (4) reported that malignant cells appeared to enter the CNS through a deficiency in the BBB around the subarachnoid vessels. Composite meningioma and lymphoma has been reported as a form of tumor-to-tumor metastasis (10). Previous disruption of the BBB by meningioma may be considered as the grounds for invasion of CNS lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Secondary central nervous system lymphoma surrounding a region injured by subarachnoid hemorrhage and subsequent aneurysmal clipping

Murata

Hata²,

Noda³

et al. 2017

Biomedical Reports

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Abstract. The present case study describes a rare case of secondary central nervous system (CNS) lymphoma that infiltrated the dura and leptomeninges around the area injured by subarachnoid hemorrhage and subsequent aneurysmal clipping. Invasion of the CNS was observed by computed tomography as slurred fissures of the right parietal lobe adjacent to the surgery area. Subdural and subarachnoid enhancement overlapping the area injured by past surgical procedures was observed by contrast-enhanced magnetic resonance imaging. Surgical resection revealed B-cell lymphoma infiltrating the dura and leptomeninges surrounding the post-hemorrhagic area. The patient was subsequently diagnosed with systemic lymphoma and bone marrow invasion, and multiple lymph node swelling. To the best of our knowledge, this is the first report of malignant lymphoma involving the CNS overlapping a previously injured area. IntroductionLeptomeningeal infiltration is frequently encountered (1), and dural infiltration is not rare with secondary central nervous system (CNS) lymphoma (1,2). However, unless systemic lymphoma has already been identified, a finding of subdural and subarachnoid abnormality would not be directly linked to lymphoma (3). Furthermore, computed tomography (CT) and magnetic resonance imaging (MRI) abnormalities surrounding hemorrhagic and postoperative changes make it difficult to distinguish between onset of disease and postoperative complications, including metal artifacts. However, malignant cells that enter the CNS appear first in the dura and subarachnoid space in rats with a blood brain barrier (BBB) disrupted by focal injury following exposure to a cold temperature (4). Previous history of subarachnoid hemorrhage (SAH) and aneurysm clipping may be associated with CNS infiltration in systemic lymphoma. The current study describes a particularly rare case of systemic lymphoma involving the CNS overlapping with the area of injury to the dura and leptomeninges due to an aneurysmal SAH. To the best of our knowledge, no similar cases have previously been reported. Case reportA 56-year-old woman with a history of aneurysm clipping following acute SAH due to rupture of the right middle cerebral arterial aneurysm 6 years earlier (Fig. 1) was hospitalized at Kochi Health Sciences Center for sudden numbness of the left arm. The patient had not experienced malignant or benign diseases within the 6 years since discharge from hospital. The patient had been asymptomatic except for partial paralysis due to SAH. Unenhanced CT was performed to exclude the recurrence of SAH, and it revealed slurred fissures of the right parietal region and enlargement of the low-density area surrounding the preceding hemorrhagic scar was suspected (Fig. 2). In addition, MRI was performed (Fig. 3). Diffusion-weighted imaging (DWI) demonstrated a thin crescent of hyperintensity in the right temporo-occipital region, although the parenchyma near the right Sylvian fissure exhibited loss of signal with distortion due to a magnetic susceptibility artifact. F...

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A Rapidly Expanding Scalp Mass

2017

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A woman in her 80s presented to the emergency room (ER) with a 2-week history of enlarging left parietal scalp mass. She initially was seen by her primary care practitioner, where neurological examination was nonfocal. The mass continued to enlarge and she developed progressive generalized weakness, slowed speech, and focal right-handed weakness. Acute onset of headache and decline in mental status prompted presentation to the ER. On examination an 8-cm left parietal mass was tender to palpation. Treatment with 4 mg of dexamethasone was initiated intravenously. All biochemical laboratory results were normal. Brain magnetic resonance imaging showed a large enhancing left frontal-parietal mass extending both extracranially and intracranially into the superior sagittal sinus (Figure). There was left frontal, parietal, and temporal bone involvement, and left dural thickening. Intracranially, there was adjacent vasogenic edema and associated mass effect. Computed tomographic (CT) scans of the chest, abdomen, and pelvis revealed a ground-glass sclerotic lesion of the right sacrum. Owing to involvement of the superior sagittal sinus and progressive growth, an ultrasound-guided core needle biopsy was performed.

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Marginal zone B-cell lymphoma involving a longstanding fibrous meningioma: an initial manifestation of systemic disease

Cited by 9 publications

References 13 publications

Coexistence of intracranial marginal zone B-cell lymphoma and meningioma: Case report and review of the literature

Coexistence of intracranial marginal zone B-cell lymphoma and meningioma: Case report and review of the literature

Secondary central nervous system lymphoma surrounding a region injured by subarachnoid hemorrhage and subsequent aneurysmal clipping

A Rapidly Expanding Scalp Mass

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