Marginal Vacuoles in Fine Needle Aspiration Biopsy Smears of Toxic Goiters

Nilsson, Göran

doi:10.1111/j.1699-0463.1972.tb00282.x

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…Nilsson originally described these in 1972 . These are commonly found in the peripheral cytoplasm of follicular cells in May–Grünwald–Giemsa (May–Grunwald–Giemsa) stained smears of the thyroid gland and have been described as a useful cytomorphologic feature of follicular cells by some authors . They are considered as highly suggestive of thyrotoxicosis, however, can be seen in other follicular lesions including adenomas and also in metastatic FTC .…”

Section: Discussionmentioning

confidence: 99%

Cytodiagnosis of distant metastases from follicular thyroid carcinoma

Gupta

Bardia

Rajwanshi

et al. 2015

Diagnostic Cytopathology

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Section: Discussionmentioning

confidence: 99%

Cytodiagnosis of distant metastases from follicular thyroid carcinoma

Gupta

Bardia

Rajwanshi

et al. 2015

Diagnostic Cytopathology

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“…In cytologic preparations, the marginal vacuoles (MVs) giving rise to fire-flare appearance has been described as a distinctive feature of thyrotoxic goiter in hyperthyroidism and MVs have also been reported in nontoxic (colloid) goiter, Hashimoto thyroiditis, and neoplastic goiters including follicular neoplasm (FN), metastatic follicular carcinoma, and follicular variant of papillary carcinoma. [ 13 ] In earlier studies, MVs were described as markedly dilated cisterns of endoplasmic reticulum playing a central role in the formation of protein in the follicular cells,[ 14 ] colloid suds, a manifestation of active pinocytosis of thyroglobulin,[ 15 ] or peripheral cytoplasmic vacuoles containing colloid. [ 16 ] In a cytomorphological study of thyroid lesions, Das[ 4 ] demonstrated the scalloping of colloid, the presence of pinocytic vesicles at the apical end of follicular cells and MVs giving rise to fire-flare appearance at the basal aspect of follicular cells [ Figure 2 ]; the author[ 4 ] made the following conclusion: if the scalloped appearance in histology represents hyperactivity because of excessive pinocytosis of colloid at the luminal side of follicular cells, MVs in MGG stained cytologic preparations are likely to represent the events at the opposite end, that is, the process of diffusing out of the thyroid hormones (T 3 and T 4 ) at the basal aspect of follicular cells on their way to interfollicular capillaries.…”

Section: R Elease Of T Hyroid Hmentioning

confidence: 99%

Functional state of cells during their life and on their journey toward inactivity and death: Search for morphological evidence in thyroid fine needle aspiration smears

Das

2018

J Cytol

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Synthesis and storage of thyroglobulin as well as synthesis of thyroid hormones and their release into the circulation are important functions of thyroid, which were studied in fine needle aspiration (FNA) smears from thyroid lesions. Evidence of thyroglobulin synthesis was demonstrated in neoplastic and nonneoplastic follicular cells, especially in Hürthle cells, in the form of colloid inclusions. Whereas the pinocytic vesicles containing colloid at the luminal end of in nonneoplastic and neoplastic follicular cells indicated engulfment of colloid for synthesis of thyroid hormones (T3 and T4), the marginal vacuoles (MVs) (fire-flare appearance) at the basal aspects of follicular cells suggested their release on way to the interfollicular capillaries. The morphological evidence of secretary activity could also be demonstrated in medullary thyroid carcinoma (MTC) in the form of azurophilic granules, marginal vacuoles, and intracytoplasmic lumina (ICL) with secretions; the secretory material, likely to be amyloid, present in MTC cells, and their release to the extracellular space was confirmed by positive immunocytochemical staining for calcitonin. It was found that nuclear grooves and related intranuclear cytoplasmic inclusions (INCIs) in papillary thyroid carcinoma (PTC) possibly represent an initial step of a degenerative process leading to formation of inactive cerebriform nuclei. Based on observation regarding formation and release of precursor substances for psammoma bodies (PBs), it was also suggested that PBs may not represent a process of dystrophic calcification over infarcted/dead papillae but suggest an active biological process, which leads to inhibition of growth of neoplastic cells and acts as a barrier against spread of PTC.

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“…Thereafter, they were assigned to specific cytological diagnoses, based on their cytomorphologies. The MVs were studied and graded (loosely based on the criteria which were given by Nilsson G.et al, [10] as per the following criteria:-Moderate + abundant MVs/grade II +III were observed in 5 out of 15 cases (30%) of the follicular neoplasms [Table/ Fig-2]. Coming to papillary carcinomas, only a solitary case (1 out of 11; 9%) was endowed with moderate /grade II MVs [Table/ Fig-3].…”

Section: Methodsmentioning

confidence: 99%

The Diagnostic Role of the Marginal Vacuoles in FNAC of Solitary Thyroid Nodules

Gupta

Sharma²,

Kalhan³

et al. 2013

JCDR

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Context: FNAC thyroid is more sensitive as well as specific in segregating neoplastic and non-neoplastic thyroid lesions. Identification of predominant cell pattern, cell morphology and background details in FNAC smears play an important role in categorisation of various thyroid lesions with accuracy. Marginal vacuoles (MVs) have been described as irregular cytoplasmic vacuoles with largely unstained central area. MVs, although suggestive of thyrotoxicosis, are non-specific, as they are also encountered in non-toxic goitre, Hashimoto's thyroiditis and follicular carcinoma. This cytologic finding therefore deserves further study to precisely delineate its utility. Methods & Material:Forty patients having solitary thyroid nodule were subjected to FNAC on an outpatient basis. Their cytomorphological features were studied with special attention to presence of MVs. MVs if present were then graded as no/ scant (gradeI ), moderate (gradeII) and abundant (gradeIII).Results and Conclusion: Majority (77.5%) of nodular goitres had insignificant MVs (gradeI) in their smears. Significant MVs (gradeII+III) were limited to autoimmune thyroiditis presenting as solitary nodule and follicular neoplasms. Abundant MVs/ gradeIII were seen in follicular neoplasm only. MVs were not present in rest of neoplastic goitres. This implies that MVs are a marker of follicular differentiation.

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Marginal Vacuoles in Fine Needle Aspiration Biopsy Smears of Toxic Goiters

Cited by 4 publications

References 12 publications

Cytodiagnosis of distant metastases from follicular thyroid carcinoma

Cytodiagnosis of distant metastases from follicular thyroid carcinoma

Functional state of cells during their life and on their journey toward inactivity and death: Search for morphological evidence in thyroid fine needle aspiration smears

The Diagnostic Role of the Marginal Vacuoles in FNAC of Solitary Thyroid Nodules

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