Purpose: The purpose of this study was to determine the influence of CAD/CAM system type and immediate dentin sealing (IDS) on the marginal fit of hybrid ceramic endocrowns. Material and Methods: Forty recently extracted lower molars were selected, and standardized prepared to receive endocrown restorations .All restorations were milled in hybrid ceramic (VITA ENAMIC® for CEREC®/ inLab®, VITA Zahnfabrik H. Rauter GmbH & Co.KG., Germany). The teeth were assigned to 4 groups (n=10) according to: (1) The type of CAD/CAM system: a) DOF system (DOF Inc., Seoul, South Korea) and b) CEREC inLab system (Sirona Dental Systems, Germany)], (2) The timing of dentin sealing. a) Immediate dentin sealing (IDS) and b) Delayed dentin sealing (DDS)].The vertical marginal gaps were then measured using measuring Stereomicroscope (Nikon Eclips E600, Tokyo, Japan). The obtained data were submitted to Kruskal-Wallistest (α=.05). Results: All marginal gap values found in this study were below the clinically acceptable value of restorations which is 120 µm. A significant difference was found between group 1 (DOF, IDS), group 2 (DOF ,DDS) and between group3 (CEREC , DDS), group 4 (CEREC, IDS) also between group 2(DOF, DDS) and 4 (CEREC, IDS). Conclusion: This study concluded that there is a significant effect of the CAD \CAM system and the timing of dentin sealing application on the marginal fit of the Hyprid ceramic endocrown restorations, where CEREC in-lab system and the immediate dentin sealing decrease the marginal adaptation .