Maresin-1 and Inflammatory Disease

Abstract

Inflammation is an essential action to protect the host human body from external, harmful antigens and microorganisms. However, an excessive inflammation reaction sometimes exceeds tissue damage and can disrupt organ functions. Therefore, anti-inflammatory action and resolution mechanisms need to be clarified. Dietary foods are an essential daily lifestyle that influences various human physiological processes and pathological conditions. Especially, omega-3 fatty acids in the diet ameliorate chronic inflammatory skin diseases. Recent studies have identified that omega-3 fatty acid derivatives, such as the resolvin series, showed strong anti-inflammatory actions in various inflammatory diseases. Maresin-1 is a derivative of one of the representative omega-3 fatty acids, i.e., docosahexaenoic acid (DHA), and has shown beneficial action in inflammatory disease models. In this review, we summarize the detailed actions of maresin-1 in immune cells and inflammatory diseases.

Exploring the Links between Obesity and Psoriasis: A Comprehensive Review

“…Recently, Maresin’s role in inflammation resolution failure in psoriasis has been highlighted because Maresin-1 enhances phagocytic activity in macrophages promoting their anti-inflammatory action by M2 polarisation (CD11c- CD206+) as well as inhibiting the polarisation of CD11c+ CD206- (M1) macrophages [ 109 ]. Furthermore, it should be remembered that M2 macrophages secrete anti-inflammatory cytokines such as IL-10 and TGF-β, which accelerate tissue remodelling and the elimination of apoptotic debris by phagocytosis, inhibiting the inflammatory response [ 110 ].…”

“…Maresin-1 has been shown to suppress neutrophil infiltration and decrease the production of CXCL1, a major chemokine for recruiting this cell type. In addition, maresin-1 promote neutrophil apoptosis to induce resolution of the inflammatory response [ 109 , 114 ]. Indeed, topical application of maresin-1 showed anti-inflammatory effects in an imiquimod-induced psoriasis mouse model by inhibiting the production of IL-17A by γδTCR mid+ and CD4+ cells in the skin through repression in IL-23 receptor expression.…”

Maresin1 Suppresses High-Glucose-Induced Ferroptosis in Osteoblasts via NRF2 Activation in Type 2 Diabetic Osteoporosis

“…MaR1, according to early studies, is a family of naturally occurring anti-inflammatory, pro-resolving mediators found in human tissue fluids. Maresins have been proven in numerous studies to have critical preventive effects against a variety of diseases [ 15 , 57 , 58 ]. These lipid media have unique receptors with a smaller physiologically dynamic range than other protein molecules, often at nano- to dermal molar concentrations.…”

“…Maresin1 (MaR1), a derivative of one of the primary omega-3 fatty acids (docosahexaenoic acid, DHA), is an endogenous pro-resolving lipid mediator produced mainly by macrophages. It has been demonstrated to significantly impact oxidative stress and inflammation [ 13 , 14 , 15 ]. MaR1 has been found to have strong protective effects on the joints [ 16 ], respiratory system [ 17 ], and neurological system [ 18 ].…”

Protective Potential of Maresins in Cardiovascular Diseases

“…Thus, boosting inflammation resolution without being overtly immunosuppressive via supplementation of pro-resolving mediators has become new strategy for the treatment of cardiovascular diseases. Maresins are a new family of bioactive lipid mediators synthesized from an ω-3 polyunsaturated fatty acid DHA and have displayed strong anti-inflammatory and pro-resolving abilities and broad beneficial actions in many inflammatory diseases ( 62 , 63 ). In the current review, by overviewing the studies of Maresins, MaR1 in particular, in the common inflammation associated cardiovascular diseases ( Figure 2 ), we can conclude that administration of MaR1 may serve as a promising therapeutic option and it will be of great significance to synthesize drugs based on endogenous Maresins for the treatment of cardiovascular disease.…”