Marek’s Disease Virus (Gallid alphaherpesvirus 2)-Encoded miR-M2-5p Simultaneously Promotes Cell Proliferation and Suppresses Apoptosis Through RBM24 and MYOD1-Mediated Signaling Pathways

Zhu, Zengtai; Teng, Maikun; Li, Huizhen; Zheng, Luping; Liu, Jinling; Chai, Shujun; Yao, Yongxiu; Nair, Venugopal; Zhang, Gaiping; Luo, Jun

doi:10.3389/fmicb.2020.596422

Cited by 7 publications

(2 citation statements)

References 64 publications

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“…A good example is Marek's disease virus (MDV), which has evolved from a relatively harmless paralytic syndrome into a highly virulent pathogen [153][154][155]. Marek's disease is caused by oncogenic Gallid alphaherpesvirus 2 (GaHV-2), commonly known as MDV type 1 (MDV-1) [154,156,157]. This disease is characteristic for young chickens, but older birds can also be affected.…”

Section: Trichosporon Asahiimentioning

confidence: 99%

Poultry house as point source of intense bioaerosol emission

Górny,

Gołofit-Szymczak,

Cyprowski

et al. 2023

Ann Agric Environ Med.

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Introduction and Objective.Intensive poultry farming is usually associated with massive exposure to organic dust, which is largely composed of microbiological origin particulates. The aim of the study is to assess occupational and environmental exposures to airborne bacteria, fungi, and Marek's disease virus emitted by a poultry house. Materials and method. The concentrations of airborne microorganisms in a poultry house and its vicinity (250-500 m) at 3 different stages of the production cycle (i.e. empty poultry house, with 7-day-old and 42-day-old chickens) were stationary measured using Andersen and MAS impactors, as well as Coriolis and BioSampler impingers. The collected microbiota was taxonomically identified using molecular and biochemical techniques to characterize occupational exposure and its spatial dissemination.Results. Although Marek's disease virus was not present in the tested air samples, the appearance of reared chickens in the poultry house resulted in an increase in airborne bacterial and fungal concentrations up to levels of 1.26 × 10 8 CFU/m 3 and 3.77 × 10 4 CFU/m 3 , respectively. These pollutants spread around through the ventilation system, but their concentrations significantly decreased at a distance of 500 m from the chicken coop. A part of the identified microbiota was pathogens that were successfully isolated from the air by all 4 tested samplers. Conclusions. The poultry house employees were exposed to high concentrations of airborne microorganisms, including pathogens that may lead to adverse health outcomes. To protect them, highly efficient hygienic and technical measures regarding the poultry house interior and its ventilation, respectively, should be introduced to prevent both unwanted pollution and subsequent emission of microbial contaminants during intensive chicken breeding.

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Section: Trichosporon Asahiimentioning

confidence: 99%

Poultry house as point source of intense bioaerosol emission

Górny,

Gołofit-Szymczak,

Cyprowski

et al. 2023

Ann Agric Environ Med.

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“…It was reported that MDV1-miR-M3 suppressed cisplatin-induced apoptosis by targeting SMAD2, a critical component in the transforming growth factor (TGF) β signal pathway, thus creating a cellular environment favorable to virus replication ( 111 ). Similarly, virus-encoded miR-M2-5p promotes cell viability and inhibits cell apoptosis through RBM24 and MYOD1-mediated signaling pathways ( 112 ). It seems that MDV modulates host response by self-encoded miRNAs targeting cellular proteins to favor viral survival and replication during viral infection.…”

Section: Innate Immune Evasion By Marek’s Disease Virus (Mdv)mentioning

confidence: 99%

Advances on Innate Immune Evasion by Avian Immunosuppressive Viruses

Wang

Zheng

2022

Front. Immunol.

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Innate immunity is not only the first line of host defense against pathogenic infection, but also the cornerstone of adaptive immune response. Upon pathogenic infection, pattern recognition receptors (PRRs) of host engage pathogen-associated molecular patterns (PAMPs) of pathogens, which initiates IFN production by activating interferon regulatory transcription factors (IRFs), nuclear factor-kappa B (NF-κB), and/or activating protein-1 (AP-1) signal transduction pathways in host cells. In order to replicate and survive, pathogens have evolved multiple strategies to evade host innate immune responses, including IFN-I signal transduction, autophagy, apoptosis, necrosis, inflammasome and/or metabolic pathways. Some avian viruses may not be highly pathogenic but they have evolved varied strategies to evade or suppress host immune response for survival, causing huge impacts on the poultry industry worldwide. In this review, we focus on the advances on innate immune evasion by several important avian immunosuppressive viruses (infectious bursal disease virus (IBDV), Marek’s disease virus (MDV), avian leukosis virus (ALV), etc.), especially their evasion of PRRs-mediated signal transduction pathways (IFN-I signal transduction pathway) and IFNAR-JAK-STAT signal pathways. A comprehensive understanding of the mechanism by which avian viruses evade or suppress host immune responses will be of help to the development of novel vaccines and therapeutic reagents for the prevention and control of infectious diseases in chickens.

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Critical roles of non-coding RNAs in lifecycle and biology of Marek’s disease herpesvirus

Teng

Zhu

Yao

et al. 2023

Sci. China Life Sci.

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Over the past two decades, numerous non-coding RNAs (ncRNAs) have been identified in different biological systems including virology, especially in large DNA viruses such as herpesviruses. As a representative oncogenic alphaherpesvirus, Marek’s disease virus (MDV) causes an important immunosuppressive and rapid-onset neoplastic disease of poultry, namely Marek’s disease (MD). Vaccinations can efficiently prevent the onset of MD lymphomas and other clinical disease, often heralded as the first successful example of vaccination-based control of cancer. MDV infection is also an excellent model for research into virally-induced tumorigenesis. Recently, great progress has been made in understanding the functions of ncRNAs in MD biology. Herein, we give a review of the discovery and identification of MDV-encoded viral miRNAs, focusing on the genomics, expression profiles, and emerging critical roles of MDV-1 miRNAs as oncogenic miRNAs (oncomiRs) or tumor suppressor genes involved in the induction of MD lymphomas. We also described the involvements of host cellular miRNAs, lincRNAs, and circRNAs participating in MDV life cycle, pathogenesis, and/or tumorigenesis. The prospects, strategies, and new techniques such as the CRISPR/Cas9-based gene editing applicable for further investigation into the ncRNA-mediated regulatory mechanisms in MDV pathogenesis/oncogenesis were also discussed, together with the possibilities of future studies on antiviral therapy and the development of new efficient MD vaccines.

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Marek’s Disease Virus (Gallid alphaherpesvirus 2)-Encoded miR-M2-5p Simultaneously Promotes Cell Proliferation and Suppresses Apoptosis Through RBM24 and MYOD1-Mediated Signaling Pathways

Cited by 7 publications

References 64 publications

Poultry house as point source of intense bioaerosol emission

Poultry house as point source of intense bioaerosol emission

Advances on Innate Immune Evasion by Avian Immunosuppressive Viruses

Critical roles of non-coding RNAs in lifecycle and biology of Marek’s disease herpesvirus

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