Marek's disease is a natural model for lymphomas overexpressing Hodgkin's disease antigen (CD30)

Burgess, Shane C.; Young, Joseph; Baaten, Bas; Hunt, Lawrence; Ross, Loretta; Parcells, Mark S.; Kumar, Pankaj; Tregaskes, Clive A.; Lee, L. F.; Davison, T.F.

doi:10.1073/pnas.0305789101

Cited by 95 publications

(98 citation statements)

References 40 publications

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“…While no expression of MATSA was found in the bursa of Fabricius, CD30 antigen was found in lymphocytes within bursal follicles. Expression of CD30 in B cells has also been reported (Burgess et al , 2004). This finding suggests that if CD30 belongs to the MATSA family (Burgess et al , 2004), then MATSA might not be restricted to activated T cells.…”

Section: Discussionsupporting

confidence: 58%

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Novel criteria for the diagnosis of Marek's disease virus-induced lymphomas

Gimeno¹,

Witter²,

Fadly³

et al. 2005

Avian Pathology

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Several novel criteria have been tested to assist in the differential diagnosis of tumours induced by Marek's disease virus (MDV) from those induced by avian leukosis virus (ALV) and reticuloendotheliosis virus (REV). A collection of tumours induced by inoculation of specific strains of MDV, ALV and REV, alone or in combination, were tested for quantification of MDV DNA by real-time polymerase chain reaction, expression of the MDV oncogene Meq, expression of several cell markers associated with transformation (CD30, Marek's disease-associated surface antigen, and p53), and level of DNA methylation in the tumour cells. In addition, tissues latently infected with MDV and non-infected tissues were tested as controls. Tumours induced by MDV had about 10 2 -fold more copies of MDV DNA than either tissues latently infected by MDV or tumours induced by retrovirus in MDV-vaccinated chickens. Moreover, the MDV antigen Meq was consistently expressed in all MDV tumours but it could not be detected in tissues latently infected with MDV or in tumours induced by retrovirus in MDV-vaccinated chickens. Other markers studied were not specific for MDV and therefore had limited value for diagnosis. Nonetheless, some of these markers might have potential value in research as they will help to identify transformed cells.

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Section: Discussionsupporting

confidence: 58%

“…MATSA may not be a single antigen, as there is a whole family of antigens under this name. It has been proposed that the antigen CD30 could belong to the MATSA family (Burgess et al , 2004). In this work, expression of MATSA and CD30 were very similar.…”

Section: Discussionsupporting

confidence: 48%

Novel criteria for the diagnosis of Marek's disease virus-induced lymphomas

Gimeno¹,

Witter²,

Fadly³

et al. 2005

Avian Pathology

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“…Apart from being an economically important disease affecting poultry health and welfare (2), Marek's disease (MD) has contributed significantly to our understanding of herpesvirus-associated oncogenicity. MD lymphomas have many biological parallels with lymphoid neoplasia associated with human herpesviruses such as Epstein-Barr virus (EBV) (3), and recent studies have suggested MD as a natural model for lymphomas overexpressing Hodgkin's disease antigen, CD30 (4). Unlike in humans, the control of many herpesvirus diseases in veterinary medicine is achieved through vaccination.…”

mentioning

confidence: 99%

Interaction of MEQ protein and C-terminal-binding protein is critical for induction of lymphomas by Marek’s disease virus

Brown

Baigent

Smith

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

105

100

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Marek's disease virus (MDV) is an oncogenic herpesvirus that induces fatal T cell lymphomas in chickens.With more than 20 billion doses of vaccine used annually, vaccination constitutes the cornerstone of Marek's disease control. Despite the success of vaccination, evolution of virulence among MDV strains continues to threaten the effectiveness of the current Marek's disease vaccines. MDV-encoded protein MEQ (MDV EcoRI Q) probably acts as a transcription factor and is considered to be the major MDV oncoprotein. MEQ sequence shows a Pro-Leu-Asp-Leu-Ser (PLDLS) motif known to bind C-terminal-binding protein (CtBP), a highly conserved cellular transcriptional corepressor with roles in the regulation of development, proliferation, and apoptosis. Here we show that MEQ can physically and functionally interact with CtBP through this motif and that this interaction is critical for oncogenesis because mutations in the CtBP-interaction domain completely abolished oncogenicity. This direct role for MEQ-CtBP interaction in MDV oncogenicity highlights the convergent evolution of molecular mechanisms of neoplastic transformation by herpesviruses because Epstein-Barr virus oncoproteins EBNA 3A and 3C also interact with CtBP. We also demonstrate that the nononcogenic MDV generated by mutagenesis of the CtBP-interaction domain of MEQ has the potential to be an improved vaccine against virulent MDV infection. Engineering MDV with precisely defined attenuating mutations, therefore, represents an effective strategy for generating new vaccines against this major poultry disease. viral oncogenesis ͉ vaccines ͉ transcriptional repression

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“…Choroba Mareka to wysoce zakaźna choroba wirusowa drobiu grzebiącego, rozpatrywana w szerokim zakresie, jednak przede wszystkim jako chłoniak T-komórkowy (8). Mimo iż po raz pierwszy została opisana w 1907 r. przez Josepha Mareka (26), to pierwsze przypadki tej choroby w Polsce pojawiły się dopiero w latach 70.…”

Section: Artykuł Przeglądowy Reviewunclassified

Applying the isothermal DNA amplification method in identifying the Marek’s disease virus in poultry

Józefiak¹,

Kufel²,

Wilczyński³

2017

Medycyna Weterynaryjna

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SummaryMarek's disease is a viral disease, a type of poultry cancer. It is caused by MDV serotype 1 (Marek's disease virus, MDV) viruses, also referred to as Gallid herpesvirus 2 belonging to the family Herpesviridae. The complete, fully infectious virus particles are present in the feathers and the nodules months can survive in the environment for many months. The use of isothermal amplification methods of genetic material (LoopMediated Isothermal Amplification, LAMP) virus MDV enables rapid and precise identification of the virus in difficult diagnostic material, including dust. By optimizing the reaction conditions and using at least two pairs of primers which bind to specific sites in the genome of the virus, this technique has high sensitivity and specificity. The technique makes it possible to detect of single copies of the meq oncogene -a unique region of DNA of the first type of virus MDV.

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Marek's disease is a natural model for lymphomas overexpressing Hodgkin's disease antigen (CD30)

Cited by 95 publications

References 40 publications

Novel criteria for the diagnosis of Marek's disease virus-induced lymphomas

Novel criteria for the diagnosis of Marek's disease virus-induced lymphomas

Interaction of MEQ protein and C-terminal-binding protein is critical for induction of lymphomas by Marek’s disease virus

Applying the isothermal DNA amplification method in identifying the Marek’s disease virus in poultry

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