Marchiafava-Bignami disease triggered by poorly controlled diabetes mellitus

Álvarez, A.I. Pérez; Carbajo, C. Ramón; Tassa, Germán Morís de la; Gomez, Jessica

doi:10.1016/j.nrleng.2015.01.002

Cited by 11 publications

(7 citation statements)

References 9 publications

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“…The splenium of corpus callosum, posterior limb of bilateral internal capsule, and bilateral middle cerebellar peduncles were involved in one case. The splenium of corpus callosum and precentral gyrus were involved in one case [11]- [15]. We presumed that wide fluctuations in blood sugar, frequent significantly hyperglycemia, and hyperosmolar state caused changes in osmotic pressure in glial cells, structural and functional changes similar to the "central pontine myelinolysis".…”

Section: Discussionmentioning

confidence: 98%

Alcoholic and Non-Alcoholic Marchiafava-Bignami Disease: A Comparative Study

Chen¹,

Wang²,

Wang³

et al. 2016

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Purpose: Marchiafava-Bignami Disease (MBD) is a rare condition mainly associated with alcoholism, although a few non-alcoholic cases have been reported. We performed a comparative study of demographic and clinical differences between alcoholic and non-alcoholic and assessed whether any treatment can be recommended. Methods: We reviewed 157 reports containing data on 168 subjects with Alcoholic MBD (AMBD) and 23 subjects with Non-Alcoholic MBD (NAMBD). The following data were extracted: demographic characteristics; delay from the onset of symptoms to admission; MRI features; location of the corpus callosum lesions; the presence of Wernicke's disease; drug treatment (thiamine, other vitamins and steroids); outcome. Results: The subjects with AMBD were more frequently men (84.5% vs 47.8, P = 0.000); the ones with AMBD were frequently reported as suffering from malnutrition (81.3% vs 50%, P = 0.019), whereas the NAMBD was frequently reported as suffering from diabetes mellitus (30.4% vs 7.1%, P = 0.002). The lesions in the NAMBD are often located in the splenium (47.8%), whereas single splenial lesions are seen only in 18.7% of the AMBD. 43.5% (10/23) of the NAMBD was reported to have recovered completely, whereas only 15.4% (24/156) AMBD showed a complete recovery. Conclusions: It is important to diagnose NAMBD in the early stage with MRI and to treat the symptoms with thiamine and/or corticosteroids according to aetiology. We recommend prompt treatment of MBD with parenteral thiamine in subjects associated with malnutrition, anorexia nervosa and prolonged vomiting, and reduction of food intake. Corticosteroids may aid in recovery by reducing oedema in subjects associated with diabetes mellitus.

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Section: Discussionmentioning

confidence: 98%

Alcoholic and Non-Alcoholic Marchiafava-Bignami Disease: A Comparative Study

Chen¹,

Wang²,

Wang³

et al. 2016

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“…Some case reports of MBD have been reported in patients with severe osmotic disorder who were not alcoholics, suggesting that abrupt changes in serum osmolality lead to demyelination of the corpus callosum. 5 , 6 , 7 Another report suggested that cytotoxic edema of the corpus callosum caused by various etiologies, such as increased neurotransmitters including glutamate and cellular energy loss, is an important mechanism for this condition. 1 , 8 This pathophysiology is associated with extremely high BAC, which causes a marked change in blood osmolality and has direct/indirect cytotoxic effects on the brain.…”

Section: Discussionmentioning

confidence: 99%

Acute alcohol intoxication presenting acquired lesion of the corpus callosum in a young healthy woman: A case of possible Marchiafava–Bignami disease

Watanabe,

Atagi,

Makino

et al. 2024

Acute Medicine & Surgery

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BackgroundMarchiafava–Bignami disease is a rare neurological disease characterized by acquired lesions of the corpus callosum. Although the major causative etiology is chronic alcoholism, a case caused by acute alcohol intoxication has not yet been reported.Case PresentationA 19‐year‐old female with no known medical history or a history of chronic alcohol consumption was brought to the emergency department in a coma after binge alcohol consumption. Even after an overnight observation, she remained comatose. After a thorough examination including magnetic resonance imaging, which showed lesions of the corpus callosum, she was treated with thiamine for Marchiafava–Bignami disease. She recovered completely and at the follow‐up, the callosum lesion had resolved.ConclusionThis is a rare case within the spectrum of Marchiafava–Bignami disease caused by acute consumption of alcohol. Clinicians should be aware of this potentially devastating critical condition among patients with severe alcohol intoxication, which might have been overlooked.

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“…Few case reports of MBD have also been reported in patients with dramatic fluctuations in the serum glucose level in the setting of poorly controlled diabetes suggesting abrupt changes in serum osmolality leading to demyelination of the corpus callosum. 3,4 Chronology of events and the range of clinical symptoms may vary. Psychiatric disturbances, dysarthria, apraxia, and signs of interhemispheric disconnection may also be noticed.…”

Section: Discussionmentioning

confidence: 99%

Overreligious beliefs with neuropsychiatric manifestations in a young lady—Rule out Marchiafava–Bignami disease

Jha¹,

Sharma

Sharda³

et al. 2019

Medical Journal Armed Forces India

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Marchiafava-Bignami disease is a rare condition characterized by demyelination of corpus callosum due to alcohol or malnutrition. Here we report a young lady who, due to her religious beliefs had stopped taking food and presented with neuropsychiatric manifestations. Neuroimaging was suggestive of Marchiafava Bignami disease and with adequate nutritional and thiamine therapy she had dramatic improvement clinically and had near complete resolution of lesions in neuroimaging.

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Marchiafava-Bignami disease triggered by poorly controlled diabetes mellitus

Cited by 11 publications

References 9 publications

Alcoholic and Non-Alcoholic Marchiafava-Bignami Disease: A Comparative Study

Alcoholic and Non-Alcoholic Marchiafava-Bignami Disease: A Comparative Study

Acute alcohol intoxication presenting acquired lesion of the corpus callosum in a young healthy woman: A case of possible Marchiafava–Bignami disease

Overreligious beliefs with neuropsychiatric manifestations in a young lady—Rule out Marchiafava–Bignami disease

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