Marchantin A Trimethyl Ether: Its Molecular Structure and  Tubocurarine-like Skeletal Muscle Relaxation Activity.

Taira, Zenei; Takei, Masao; Endo, Katsuhiro; Hashimoto, Toshihiro; Sakiya, Yoko; Asakawa, Yoshinori

doi:10.1248/cpb.42.52

Cited by 37 publications

(19 citation statements)

References 2 publications

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“…At a concentration of 10 -6 M, the contraction of RAF decreased by about 30%. (Asakawa, 1993;Taira et al, 1994 [61] pointed out a structural similarity between marchantin A (1) and the therapeutically important bis-bibenzyl isoquinoline alkaloid, cepharathine. They predicted that the similar therapeutic properties of 1 and cepharathine could be attributed to their binding to a common receptor.…”

Section: Muscle Relaxing and Calcium Inhibitory Activitymentioning

confidence: 99%

The Isolation, Structure Elucidation, and Bio- and Total Synthesis of Bis-bibenzyls, from Liverworts and Their Biological Activity

Asakawa

2017

Natural Product Communications

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Little attention has been paid to the bryophytes for use in the human diet in spite of the presence of 23,000 species in the world. Some liverworts produce lipophilic terpenoids and phenolic bis-bibenzyls, possessing antimicrobial, antifungal, antiviral, cytotoxic, anti-oxidant, muscle relaxing, and antiobesity activities. In this review, the isolation, structures elucidation, bio-and total syntheses of bis-bibenzyls from several liverworts are discussed.

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Section: Muscle Relaxing and Calcium Inhibitory Activitymentioning

confidence: 99%

The Isolation, Structure Elucidation, and Bio- and Total Synthesis of Bis-bibenzyls, from Liverworts and Their Biological Activity

Asakawa

2017

Natural Product Communications

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“…The bone density was measured using the crystal density method by performing sink/float measurements in a dense aqueous solution of potassium iodide at 25°C. The density of the aqueous solution was measured using a pycnometer 25) .…”

Section: Biochemical Assaysmentioning

confidence: 99%

Effects of Hachimi-jio-gan Extract on Intestinal Absorption of Calcium in Ovariectomized Mice and Stimulation of RANKL-induced Osteoclast Differentiation of Raw264.7 Cells by Lipopolysaccharide

Ueda

Kanayama

Yamauchi

et al. 2012

J. Hard Tissue Biology.

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: Osteoporosis is a common metabolic bone disease often affecting postmenopausal women, and various medicines are available that attempt to treat and/or prevent this disease. Hachimi-jio-gan is a traditional oriental (Kampo) medicine used clinically, but it's mode of action is still unknown. In this study, the effects of Hachimi-jio-gan extract on intestinal calcium absorption were evaluated in an osteoporosis model using ovariectomized (OVX) and sham-operated (SHAM) mice by investigating pharmacokinetic parameters in these animals. The ability of Hachimi-jio-gan extract to inhibit lipopolysaccharide-mediated stimulation of osteoclasts in bones using receptor activator of the NF-kB ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells was also investigated. The metabolic behavior of calcium did not differ between OVX and SHAM mice as the pharmacokinetics of calcium was equivalent after intravenous administration. The absolute bioavailability of calcium indicated that the extent of intestinal calcium absorption in the OVX (10.3%) and SHAM (10.7%) mice was at similar low levels. Hachimi-jio-gan extract potentially improved the intestinal calcium absorption by 1.96-and 1.86-fold, respectively. Hachimi-jio-gan extract further suppressed the potent stimulation of RANKL-induced osteoclast differentiation in RAW264.7 cells. These results suggest that Hachimi-jio-gan extract may be suitable for treatment and prevention of osteoporosis through its ability to increase intestinal calcium absorption and suppress osteoclast differentiation.

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“…These natural products reportedly have diverse biological activities; these include cytotoxic [42,43], antimicrobial and antifungal [44][45][46], thrombin, 5-lipoxygenase, cyclooxygenase and DNA polymerase inhibitory [47][48][49], anthelmintic [50], musclerelaxing [51], as well as antioxidative [52] properties. The bis(bibenzyl)s are mainly responsible for the antimicrobial and antifungal effects of liverworts [36].…”

Section: Brief Medicinal Historymentioning

confidence: 99%

Recent Trends in Plant-Derived Antifungal Agents

Shahid

Shahzad²,

Tripathi³

et al. 2009

AIAMC

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Recent years have witnessed emergence of resistance to azoles and other antifungal compounds. Moreover, the existing antifungal compounds for the contemporary clinicians are limited in numbers as opposed to available antibacterial compounds. Hence there is a real need to search for newer compounds with potential antifungal activity. In this review, the potential of medicinal plant species to yield newer antifungal agents would be illustrated with an emphasis on compounds discovered in recent years. Some of the issues pertinent to this area, including their botanical, medicinal, and available spectroscopic data, will briefly be reviewed and it is hoped that this would definitely stimulate for their discussions and researches on this important aspect including the mechanism of actions of these recently discovered compounds.

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Marchantin A Trimethyl Ether: Its Molecular Structure and Tubocurarine-like Skeletal Muscle Relaxation Activity.

Cited by 37 publications

References 2 publications

The Isolation, Structure Elucidation, and Bio- and Total Synthesis of Bis-bibenzyls, from Liverworts and Their Biological Activity

The Isolation, Structure Elucidation, and Bio- and Total Synthesis of Bis-bibenzyls, from Liverworts and Their Biological Activity

Effects of Hachimi-jio-gan Extract on Intestinal Absorption of Calcium in Ovariectomized Mice and Stimulation of RANKL-induced Osteoclast Differentiation of Raw264.7 Cells by Lipopolysaccharide

Recent Trends in Plant-Derived Antifungal Agents

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