March 2020 at a glance: heart failure with preserved ejection fraction, left atrial myopathy, atrial fibrillation and cardiac amyloidosis

Adamo, Marianna; Lombardi, Carlo; Metra, Marco

doi:10.1002/ejhf.1509

Cited by 1 publication

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“…Amyloid deposits in myocardium and skeletal muscle without evidence of renal involvement. It is well known that CA is most common in AL amyloidosis and ATTR amyloidosis especially wild-type (ATTRwt) ( 5 , 6 ). The extracardiac manifestations of amyloidosis vary according to the types of amyloidosis, and the amyloid nephropathy is more common in AA and AL amyloidosis, but rare in ATTR amyloidosis ( 7 ).…”

Section: Discussionmentioning

confidence: 99%

Case Report: Systemic Amyloidosis Involving the Heart and Skeletal Muscle

et al. 2022

Front. Cardiovasc. Med.

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BackgroundAmyloidosis refers to an etiologically heterogeneous group of protein misfolding diseases characterized by extracellular deposition in organs and tissues of amyloid fibers, leading to severe organ dysfunction and death. Systemic amyloidosis often involves multiple organs. Heart and kidney are the most commonly affected organs, whereas skeletal muscle involvement is rare and often accompanied by other organs’ involvement.Case SummaryWe reported a 70-year-old man manifested with myopathy followed by heart failure who was suspected of transthyretin amyloidosis clinically, after the pathological results and the 99mTc-pyrophosphate (99mTc-PYP) scintigraphy, light-chain (AL) amyloidosis involving the heart and skeletal muscle was confirmed.ConclusionThe patient’s unique presentation gives insight into a rare but debilitating disorder and the potential link between various types of amyloidosis. In addition, myopathy in amyloidosis should be recognized.

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Section: Discussionmentioning

confidence: 99%

Case Report: Systemic Amyloidosis Involving the Heart and Skeletal Muscle

et al. 2022

Front. Cardiovasc. Med.

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March 2020 at a glance: heart failure with preserved ejection fraction, left atrial myopathy, atrial fibrillation and cardiac amyloidosis

Cited by 1 publication

References 23 publications

Case Report: Systemic Amyloidosis Involving the Heart and Skeletal Muscle

Case Report: Systemic Amyloidosis Involving the Heart and Skeletal Muscle

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