Marcadores tumorais no câncer colorretal

Fernandes, Leandro; Matos, Délcio

doi:10.1590/s0100-69912002000200009

Cited by 4 publications

(4 citation statements)

References 64 publications

(79 reference statements)

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“…Carcinoembryonic antigen (CEA) is one of the most extensively studied tumor markers. Despite its low sensitivity for early-stage colorectal cancer (between 20% and 40%), CEA is still considered to be a standard serum tumor marker for following up colorectal cancer patients, with sensitivity greater than 90% for detecting recurrences (6) .…”

Section: Introductionmentioning

confidence: 99%

Analysis of the immunohistochemical expressions of p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and their correlations with the prognostic factors

Menezes

Júca

Gomes

et al. 2010

Arq. Gastroenterol.

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-Context -Search of tumors markers that allow treatment with higher survival rates, and indicate the response to treatment and recurrence of cancer -Objective -To analyze the immunoexpression of the proteins p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and correlate them with the clinical-pathological prognostic factors. Method -Tissue microarray paraffin blocks were made from colorectal adenocarcinoma tissue resected from 82 patients who had undergone surgery but not chemotherapy or radiotherapy, at "Hospital São Paulo", São Paulo, SP, Brazil, between 2002 and 2005. Thin sections (4 μm) were subjected to immunohistochemical reactions, and immunoexpression staining scores were obtained. The scores were correlated with the degree of cell differentiation, staging, disease-free interval, recurrence, survival and specific mortality. The study variables were analyzed using the chi-square and Kaplan-Meier tests to investigate associations with the markers. The significance of the differences between the curves of the diseasefree interval and survival was analyzed using the Logrank and Wilcoxon tests. Results -The immunohistochemical expression of p53 was positive in 70 tumors (85.4%) and negative in 12 (14.6%). The expression of bcl-2 was positive in 26 (31.7%) and negative in 56 (68.3%). The expression of Ki-67 was positive in 62 (75.6%) and negative in 20 (24.4%). There was no statistically significant correlation between the expressions of these markers separately or in conjunction, in relation to the degree of cell differentiation, staging, disease-free interval, survival and specific mortality. In relation to recurrence, there was a statistically significant correlation with positive expression of Ki-67 (P = 0.035). Conclusion -The immunohistochemical expression of Ki-67 in colorectal cancer is associated with recurrence of this disease. HEADINGS -Colorectal neoplasms. Adenocarcinoma. Immunohistochemistry. Tumor suppressor protein p53. Proto-oncogene proteins c-bcl-2. Bcl-2 homologous antagonist-killer protein.

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Section: Introductionmentioning

confidence: 99%

Analysis of the immunohistochemical expressions of p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and their correlations with the prognostic factors

Menezes

Júca

Gomes

et al. 2010

Arq. Gastroenterol.

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“…In 2013 in Serbia the estimated new cases of colorectal cancer were 3900, making it the second most frequent malignant tumor in the country (2). The expression of E-cadherin, carcinoembryonic antigen (mCEA), cyclin B1, erythropoietin (EPO), EPO receptor (EPOR), and vascular endothelial growth factor (VEGF) indicate the presence, extent, and response to therapy of this neoplasm and define the survival period (3,4). mCEA is one of the most extensively studied tumor markers in colon cancers.…”

Section: Introductionmentioning

confidence: 99%

“…mCEA is one of the most extensively studied tumor markers in colon cancers. During the early stage of colorectal cancer mCEA has a low sensitivity and expression; it becomes more prominent during the process of tumor development (4). E-cadherin belongs to a family of transmembrane glycoproteins involved in the mediation of calciumdependent cell-cell adhesion in epithelial tissues (5).…”

Section: Introductionmentioning

confidence: 99%

Proliferation and differentiation markers of colorectal adenocarcinomaand their correlation with clinicopathological factors

et al. 2016

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Background/aim: The purpose of this study was to investigate proliferation and differentiation markers in colorectal adenocarcinoma and their correlation with clinicopathological factors.Materials and methods: Samples were collected from 38 patients with colorectal adenocarcinoma and 10 healthy controls. E-cadherin, carcinoembryonic antigen (mCEA), cyclin B1, vascular endothelial growth factor (VEGF), and erythropoietin (EPO) receptor (EPOR) were examined by immunohistochemistry; VEGF and EPO were examined by real-time PCR. Results:The tumor samples were mostly characterized by large dimension (pT3), moderate level of differentiation (G2), negative lymph node status (N0), and no metastasis. Cyclin B1 and VEGF gene and protein expressions were significantly higher in tumor tissues than in control tissues; E-cadherin expression was significantly decreased in tumor samples and in positive correlation with mCEA. EPO was almost undetectable in tumor tissues of colorectal adenocarcinoma. Significant positive correlation was detected between tumor size and cyclin B1, tumor grade, and lymph node status. Conclusion:Decreased expression of EPO, high levels of VEGF and cyclin B1 expression, predominant moderate tumor differentiation, absence of metastasis, and negative lymph node status may suggest low level of aggressiveness, better prognosis, and longer patient survival.

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“…In the attempts to establish early diagnosis and better treatment, tumor markers are noticed, which are molecular products secreted by the neoplastic tissue, detectable in cells and organic fluids that are able to indicate the presence, extension, response to treatment and presence of neoplasm recurrence 10 . The quantification of free DNA in the peripheral blood aims to find a way to relate it to the clinical status of patients with cancer, tumor aggressiveness, and especially a way to early detect the appearance of the first neoplastic cells, or in case of recurrence.…”

Section: Introductionmentioning

confidence: 99%

Comparative study between the free DNA in peripheral blood and TNM staging in patients with colorectal cancer for prognostic evaluation in the university hospital of the State of Alagoas

Rocha¹,

Moreira²,

Freitas

et al. 2012

J. Coloproctol. (Rio J.)

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127Rocha VC, Moreira RS, Lins-Neto MAF. Comparative study between the free DNA in peripheral blood and TNM staging in patients with colorectal cancer for prognostic evaluation in the university hospital of the State of Alagoas. J Coloproctol, 2012;32(2): 127-131. ABSTRACT:Colorectal neoplasm is one of the most common cancers in developed countries and its incidence has grown progressively. The currently used attempts to prognostic assessment are limited, since they are restricted to the observation of tumor morphology, such as the TNM staging. The quantification of free DNA in peripheral blood aims to find a way to relate it to the clinical status of patients with cancer. Objective: To evaluate the prognosis of patients with colorectal cancer with the quantification of ALU247 fragments in peripheral blood and TNM staging. Methods: We evaluated 79 patients in the following groups: Operated, and Non-Operated and Control as to the ALU247 fragment dosage and its correlation with tumor staging. Results: The amount of ALU247 fragments revealed very different results when comparing the different groups. The mean quantity in the Non-Operated group was 14.62 pg, while the mean was 0.48 pg for the Control Group and 0.93 pg for the Operated Group. Serum levels of ALU247 were higher in more advanced morphofunctional classes of the TNM staging. Conclusions: We suggest there is a relation between the advanced TNM stage and high doses of free DNA in peripheral blood with worse prognosis.Keywords: colorectal neoplasia; colorectal staging; ALU 247; prognosis. RESUMO:A neoplasia colorretal é uma das formas mais comuns de câncer nos países desenvolvidos e sua incidência tem crescido de maneira contínua. As tentativas de avaliação prognóstica usadas atualmente apresentam a grave limitação de se restringirem à observação da morfologia tumoral, como o estadiamento TNM. A quantificação do DNA livre no sangue periférico busca encontrar uma forma de relacioná-lo com o estado clínico dos portadores de câncer. Objetivo: Avaliar o prognóstico dos pacientes portadores do câncer colorretal por meio da quantificação de fragmentos de ALU247 no sangue periférico e do estadiamento TNM. Métodos: Foram avaliados 79 pacientes nos Grupos Operados, Não Operados e Controle quanto à dosagem de fragmento de ALU247 e sua correlação com os estádios dos tumores. Resultados: A quantidade de fragmentos ALU247 revelou resultados bastante distintos quando os diferentes grupos foram comparados. A média da quantificação nos Não Operados foi de 14,62 pg, de 0,48 pg no Grupo Controle e 0,93 pg no Grupo Operados. Os valores séricos do ALU247 encontraram-se mais elevados nas classes morfofuncionais mais avançadas do estadiamento TNM. Conclusões: Sugere-se uma relação entre o avanço do estádio TNM e a dosagem elevada do DNA livre no sangue periférico com pior prognóstico.Palavras-chave: neoplasias colorretais; estadiamento de neoplasias; ALU247; prognóstico.Comparative study between the free DNA in peripheral blood and TNM staging in patients with colorectal cancer f...

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Marcadores tumorais no câncer colorretal

Cited by 4 publications

References 64 publications

Analysis of the immunohistochemical expressions of p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and their correlations with the prognostic factors

Analysis of the immunohistochemical expressions of p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and their correlations with the prognostic factors

Proliferation and differentiation markers of colorectal adenocarcinomaand their correlation with clinicopathological factors

Comparative study between the free DNA in peripheral blood and TNM staging in patients with colorectal cancer for prognostic evaluation in the university hospital of the State of Alagoas

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