Marcador tumoral CA 15-3 en carcinoma invasivo de mama de tipo no especial (ductal)

Medina, Miriam Paulina Arenillas; Tejedor, Jonnathan Gerardo Ortiz

doi:10.33262/anatomiadigital.v5i3.3.2331

Cited by 1 publication

(1 citation statement)

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“…Another important serological marker is CA 15-3, a protein component of MUC 1 found in epithelial cells. It is frequently utilized as a tumor marker for detecting and monitoring breast cancer [36]. However, it is noteworthy that CA 15-3 levels can also rise in other conditions, such as gastrointestinal and lung neoplasms.…”

Section: Serological Biomarkersmentioning

confidence: 99%

Exploring Biomarkers in Breast Cancer: Hallmarks of Diagnosis, Treatment, and Follow-Up in Clinical Practice

Lopez-Gonzalez,

Sanchez Cendra,

Sanchez Cendra

et al. 2024

Medicina

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Breast cancer is a prevalent malignancy in the present day, particularly affecting women as one of the most common forms of cancer. A significant portion of patients initially present with localized disease, for which curative treatments are pursued. Conversely, another substantial segment is diagnosed with metastatic disease, which has a worse prognosis. Recent years have witnessed a profound transformation in the prognosis for this latter group, primarily due to the discovery of various biomarkers and the emergence of targeted therapies. These biomarkers, encompassing serological, histological, and genetic indicators, have demonstrated their value across multiple aspects of breast cancer management. They play crucial roles in initial diagnosis, aiding in the detection of relapses during follow-up, guiding the application of targeted treatments, and offering valuable insights for prognostic stratification, especially for highly aggressive tumor types. Molecular markers have now become the keystone of metastatic breast cancer diagnosis, given the diverse array of chemotherapy options and treatment modalities available. These markers signify a transformative shift in the arsenal of therapeutic options against breast cancer. Their diagnostic precision enables the categorization of tumors with elevated risks of recurrence, increased aggressiveness, and heightened mortality. Furthermore, the existence of therapies tailored to target specific molecular anomalies triggers a cascade of changes in tumor behavior. Therefore, the primary objective of this article is to offer a comprehensive review of the clinical, diagnostic, prognostic, and therapeutic utility of the principal biomarkers currently in use, as well as of their clinical impact on metastatic breast cancer. In doing so, our goal is to contribute to a more profound comprehension of this complex disease and, ultimately, to enhance patient outcomes through more precise and effective treatment strategies.

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Section: Serological Biomarkersmentioning

confidence: 99%