Marble Bone Disease: A Rare Bone Disorder

Arumugam, Eswaran; Harinathbabu, Maheswari; Thillaigovindan, Ranjani; Prabhu, Geetha

doi:10.7759/cureus.339

Cited by 12 publications

(12 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the application of fluorides is recommended to reduce the tendency to develop caries. Figures 11 and 12 show the changes characteristic of MBD (infantile disease): Lack of significant number of teeth and a strong narrowing and, even, obliteration of the tooth canals [15]. Bone marrow spaces vascularization and partial obliteration of the mandibular canal lead to a decrease in bone resistance to various infections.…”

Section: Mbdmentioning

confidence: 99%

Hereditary Dental Diseases – Clinical Diagnosis and Strategies for Treatment and Rehabilitation

Sologova

Rzaeva

Tereshkina

et al. 2020

Open Access Maced J Med Sci

View full text Add to dashboard Cite

AIM: The research has been aimed at optimization of approaches to diagnosis, prevention, and treatment strategies to the hereditary dental diseases based on the analysis of modern relevant information. METHODS: Using the methods of content analysis and cluster analysis, the information included in periodicals, as well as educational and non-regulatory publications for the period of 2011–2019, was systematized and structured; the analysis of sources devoted to modern approaches to the diagnosis, prevention, and treatment of hereditary dental diseases, their genetic etiology, with the description of clinical cases and illustrations for each example, was conducted; hereditary dental diseases were classified; based on a comparative analysis, approaches to the diagnosis, treatment, and prevention of these diseases were optimized. RESULTS: The most significant hereditary dental diseases have been identified, the classification of approaches to their diagnosis and treatment has been presented, the scheme of drug therapy has been optimized depending on the pathology. CONCLUSION: The systematic analysis of information on hereditary dental diseases with the description of clinical cases for each nosology has been carried out for the 1st time, and the approaches to their diagnosis and treatment have been optimized with due consideration of domestic and foreign experience.

show abstract

Section: Mbdmentioning

confidence: 99%

Hereditary Dental Diseases – Clinical Diagnosis and Strategies for Treatment and Rehabilitation

Sologova

Rzaeva

Tereshkina

et al. 2020

Open Access Maced J Med Sci

View full text Add to dashboard Cite

show abstract

“…In most of the cases mentioned, radio opaque x-rays actually indicate osteosclerosis and not skeletal fluorosis, a hereditary disease also known as Albers-Schönberg disease and marble bone disease [90]. This inherited bone disease is caused by an autosomal dominant (in some patients, more severe, autosomal recessive) mutation and dysfunctional osteoclast cells.…”

Section: Dental and Skeletal Fluorosis And Ckdmfomentioning

confidence: 99%

Factors Affecting the Environmentally Induced, Chronic Kidney Disease of Unknown Aetiology in Dry Zonal Regions in Tropical Countries—Novel Findings

Wimalawansa¹,

Dissanayake

2019

Environments

View full text Add to dashboard Cite

A new form of chronic tubulointerstitial kidney disease (CKD) not related to diabetes or hypertension appeared during the past four decades in several peri-equatorial and predominantly agricultural countries. Commonalities include underground stagnation of drinking water with prolonged contact with rocks, harsh climatic conditions with protracted dry seasons, and rampant poverty and malnutrition. In general, the cause is unknown, and the disease is therefore named CKD of unknown aetiology (CKDu). Since it is likely caused by a combination of factors, a better term would be CKD of multifactorial origin (CKDmfo). Middle-aged malnourished men with more than 10 years of exposure to environmental hazards are the most vulnerable. Over 30 factors have been proposed as causative, including agrochemicals and heavy metals, but none has been properly tested nor proven as causative, and unlikely to be the cause of CKDmfo/CKDu. Conditions such as, having favourable climatic patterns, adequate hydration, and less poverty and malnutrition seem to prevent the disease. With the right in vivo conditions, chemical species such as calcium, phosphate, oxalate, and fluoride form intra-renal nanomineral particles initiating the CKDmfo. This article examines the key potential chemical components causing CKDmfo together with the risk factors and vulnerabilities predisposing individuals to this disease. Research findings suggest that in addition to drinking water from stagnant sources that contain high ionic components, more than 10 years of exposure to environmental nephrotoxins and micronutrient malnutrition are needed to contract this fatal disease.

show abstract

“…Delayed union, malunion, non-union and Varus deformities of these fractures are some of the common complications seen in these patients. Even in otherwise uneventful open reduction and internal fixation cases these patients are predisposed for development of infections which may further complicate the management [14] . We conducted this retrospective study of 20 patients with osteopetrosis who presented with femoral fracture and were treated in our institute.…”

Section: Introductionmentioning

confidence: 99%

Management of femoral fractures in adult onset osteopetrosis: A multicentric retrospective study

Rahate¹,

Tarlekar²,

Jiwani³

et al. 2018

Int. J. Orthop. Sci.

View full text Add to dashboard Cite

Background: Osteopetrosis is a relatively rare disease with an incidence of approximately 1 case per 2,00,000 to 5,00,000 population. The clinical features of osteopetrosis includes pathological fractures, severe anemia due to defective erythropoiesis, bone marrow failure, coagulation defects, propensity for developing severe infections. Common fractures seen in these patients include hip and femoral fractures. Management of fractures in these patients is technically difficult and postoperative complications are common. We conducted a retrospective study of 20 patients with osteopetrosis who presented with femoral fractures and were treated in our institute. Materials and Methods:This was a multicentric retrospective study of 20 patients with osteopetrosis who presented with femoral fractures. The patients were included in this study on the basis of predefined inclusion and exclusion criteria. The diagnosis was based upon imaging studies (X-Rays in all the patients and CT in selected cases). The operative procedure post-operative complications, functional outcome and complications during follow up were studied from case papers. The data was tabulated and analyzed using Minitab 17 version software. Results: Out of 20 studied cases there were 16 (80%) males and 4 (20%) females with a M:F ratio of 1: 0.25. The most common affected age group was found to be between 30 -35 years (35%). Majority of patient sustained fracture following motor vehicular accidents (65%) followed by fall from height (20%) and direct blow or assault (15%). 13 patients were found to be having co-morbidities including anemia, carpal tunnel syndrome and visual disturbances. Open reduction and internal fixation was done in all the cases. Technical difficulties seen during operative procedures included difficult because of obliterated canal, sclerosed medulla and dense swarf. Common complications in these patients included wound infection, hematoma formation and arthritis of hip joint (5%). Repeat surgeries were required in 3 (15%) patients and 1 (5%) patient developed non-union of the fracture ends. Conclusion: Management of femoral fracture in patients with osteopetrosis is challenging for operating orthopedic surgeon. Common problems encountered during open reduction and internal fixation include overheating during drilling, smoke production and increased temperature of both bone and drill bits and production of dense bone swarf. Orthopedic surgeon should be aware of these technical difficulties encountered during operative interventions.

show abstract

Marble Bone Disease: A Rare Bone Disorder

Cited by 12 publications

References 8 publications

Hereditary Dental Diseases – Clinical Diagnosis and Strategies for Treatment and Rehabilitation

Hereditary Dental Diseases – Clinical Diagnosis and Strategies for Treatment and Rehabilitation

Factors Affecting the Environmentally Induced, Chronic Kidney Disease of Unknown Aetiology in Dry Zonal Regions in Tropical Countries—Novel Findings

Management of femoral fractures in adult onset osteopetrosis: A multicentric retrospective study

Contact Info

Product

Resources

About