Marathon runners presented lower serum cholesteryl ester transfer activity than sedentary subjects

Serrat-Serrat, J; Ordóñez-Llanos, Jordi; Serra-Grima, Ricard; Gómez-Gerique, J.A.; Pellicer-Thoma, Esther; Payés-Romero, Amalia; González‐Sastre, Francesc

doi:10.1016/0021-9150(93)90100-9

Cited by 29 publications

(14 citation statements)

References 32 publications

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“…Recent data indicate an effect of exercise on plasma CETP activity [22,23], but our study subjects (aged 19-49 years) did not change their excercise habits during the course of the experiment [3]. As in a previous study [16], we were unable to detect significant differences in CETP activity between males and females.…”

Section: Discussionmentioning

confidence: 65%

Dietary trans fatty acids increase serum cholesterylester transfer protein activity in man

Tol¹,

Zock²,

Gent³

et al. 1995

Atherosclerosis

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The average diet may provide some 8-10 g/day of unsaturated fatty acids with a trans double bond. Previous studies showed that dietary trans fatty acids may simultaneously raise low-density lipoprotein (LDL) cholesterol and reduce high-density lipoprotein (HDL) cholesterol. Human plasma contains a protein (CETP) which transfers cholesterylesters from HDL to lipoproteins of lower density. We hypothesized that CETP could play a role in the effect of trans fatty acids on lipoproteins and measured the activity levels of CETP in serum samples from a 9-week study in which 55 volunteers were fed three controlled diets with different fatty acid profiles. Mean activity was 114 (% of reference serum) after consumption of a high trans fatty acid diet, as opposed to 96 after linoleic acid and 97 after stearic acid (P < 0.02). We conclude that the increased activity of CETP may contribute to the rise in LDL cholesterol and the fall in HDL cholesterol seen on diets with high contents of trans fatty acids.

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Section: Discussionmentioning

confidence: 65%

Dietary trans fatty acids increase serum cholesterylester transfer protein activity in man

Tol¹,

Zock²,

Gent³

et al. 1995

Atherosclerosis

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“…In general, no changes in resting hepatic lipase activity are reported between inactive and active individuals, 131 and a single exercise session results in no significant hepatic lipase activity changes. 127,134,135 Low cholesteryl ester transfer protein (CETP) activity may provide an antiatherogenic effect by slowing hepatic HDL 2 catabolism and decreasing the amount of plasma cholesterol-rich particles. Cross-sectional studies report elevated plasma CETP activity in physically active people, 87 whereas longitudinal exercise training studies report decreased CETP activity.…”

Section: Impact Of Physical Activity On Blood Lipids and Lipoproteinsmentioning

confidence: 99%

“…Cross-sectional studies report elevated plasma CETP activity in physically active people, 87 whereas longitudinal exercise training studies report decreased CETP activity. 134,135 In addition, lecithin cholesterol acyltransferase activity is increased in physically active men 136 but not after exercise training. 87,97,132 Current data support a favorable impact for exercise training on lipid and lipoprotein profiles.…”

Section: Impact Of Physical Activity On Blood Lipids and Lipoproteinsmentioning

confidence: 99%

Managing Abnormal Blood Lipids

Fletcher¹,

Berra²,

Ades³

et al. 2005

Circulation

190

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Abstract-Current data and guidelines recommend treating abnormal blood lipids (ABL) to goal. This is a complex process and requires involvement from various healthcare professionals with a wide range of expertise. The model of a multidisciplinary case management approach for patients with ABL is well documented and described. This collaborative approach encompasses primary and secondary prevention across the lifespan, incorporates nutritional and exercise management as a significant component, defines the importance and indications for pharmacological therapy, and emphasizes the importance of adherence. Use of this collaborative approach for the treatment of ABL ultimately will improve cardiovascular and cerebrovascular morbidity and mortality. (Circulation. 2005;112:3184-3209.)

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“…Total LDL from human NL plasma was isolated by gel filtration chromatography, as described previously. 13 Briefly, 10 mL of plasma was subjected to chromatography consecutively (1 mL in each chromatograph) in a Superose 6 column (Amersham Biosciences) and collected in 1-mL fractions, and cholesterol, triglyceride, apoB, and apoA-I were measured. Fraction 11, corresponding to the purest LDL fraction (apoBϭ0.20 g/L, apoA-Iϭ0.00 g/L, cholesterolϭ0.68 mmol/L, triglycerideϭ0.07 mmol/L, total volume 10 mL), was subfractionated in LDL(ϩ) and LDL(Ϫ) by anion-exchange chromatography as described above.…”

Section: Lipoprotein Isolationmentioning

confidence: 99%

Platelet-Activating Factor Acetylhydrolase Is Mainly Associated With Electronegative Low-Density Lipoprotein Subfraction

et al. 2003

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Background-Electronegative LDL [LDL(Ϫ)], a modified subfraction of LDL present in plasma, induces the release of interleukin-8 and monocyte chemotactic protein-1 from cultured endothelial cells. Methods and Results-We demonstrate that platelet-activating factor acetylhydrolase (PAF-AH) is mainly associated with LDL(Ϫ). LDL(Ϫ) had 5-fold higher PAF-AH activity than the nonelectronegative LDL subfraction [LDL(ϩ)] in both normolipemic and familial hypercholesterolemic subjects. Western blot analysis after SDS-PAGE confirmed these results, because a single band of 44 kDa corresponding to PAF-AH appeared in LDL(Ϫ) but not in LDL(ϩ).Nondenaturing polyacrylamide gradient gel electrophoresis demonstrated that PAF-AH was bound to LDL(Ϫ) regardless of LDL size. In accordance with the above findings, nonesterified fatty acids, a cleavage product of PAF-AH, were increased in LDL(Ϫ) compared with LDL(ϩ). Conclusions-The

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Marathon runners presented lower serum cholesteryl ester transfer activity than sedentary subjects

Cited by 29 publications

References 32 publications

Dietary trans fatty acids increase serum cholesterylester transfer protein activity in man

Dietary trans fatty acids increase serum cholesterylester transfer protein activity in man

Managing Abnormal Blood Lipids

Platelet-Activating Factor Acetylhydrolase Is Mainly Associated With Electronegative Low-Density Lipoprotein Subfraction

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