Marantic Endocarditis With Cardioembolic Strokes Mimicking Leptomeningeal Metastases in Breast Cancer

Arvold, Nils D.; Hsu, Liangge; Chen, Wendy Y.; Benzaquen, Laura R.; Weiss, Stéphanie

doi:10.1200/jco.2011.36.4190

Cited by 5 publications

(4 citation statements)

References 22 publications

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“…It has been suggested that NBTE is associated with a higher incidence of stroke (33%) as compared with infective endocarditis (19%) . Part of the difficulty in making a diagnosis of NBTE is that its presentation can mimic other conditions such as leptomeningeal metastases and infective endocarditis. Diffusion‐weighted MRI can potentially demonstrate differences between cardio‐embolic strokes from infective endocarditis and NBTE.…”

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confidence: 99%

Marantic endocarditis presenting with multifocal neurological symptoms

Wong

Seow

Profitis

et al. 2013

Internal Medicine Journal

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Non-bacterial thrombotic endocarditis (NBTE), also known as marantic endocarditis, has been reported to occur in 0.3-9.3% of the adult population at autopsy. NBTE associated with malignancy is an underrecognised cause of thromboembolic disorders. The clinical spectrum encountered and investigation results can be non-specific, often mimicking other acute conditions such as infective endocarditis. We describe the case of a 34-year-old woman with non-localising and multifocal neurological symptoms, who was subsequently diagnosed with NBTE secondary to a resectable primary lung adenocarcinoma.

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confidence: 99%

Marantic endocarditis presenting with multifocal neurological symptoms

Wong

Seow

Profitis

et al. 2013

Internal Medicine Journal

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“…Among 829 searched studies, 121 studies [ 19 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 ...…”

Section: Resultsunclassified

“…The flow chart of our included studies is shown in Supplementary Figure S1 . Around 25% (39) of included studies were from the USA, and only 1 study was reported from China [ 19 , 22 , 23 , 24 , 27 , 29 , 32 , 33 , 34 , 39 , 41 , 43 , 46 , 47 , 48 , 57 , 58 , 59 , 68 , 69 , 73 , 76 , 81 , 84 , 86 , 88 , 92 , 93 , 94 , 100 , 101 , 105 , 108 , 111 , 114 , 115 , 118 , 131 , 132 , 136 ]. A list of the included studies and the quality assessment are reported in Supplementary Table S2 .…”

Section: Resultsmentioning

confidence: 99%

“…It is also called “noninfective endocarditis” or “aseptic endocarditis“. This condition is most commonly associated with cancer, particularly malignant melanoma, lung, pancreas, and breast carcinomas [ 17 , 27 , 57 , 142 , 143 ]. Marantic endocarditis can also occur in patients with other types of malignancies, as well as in patients with chronic inflammatory conditions such as rheumatoid arthritis and systemic lupus erythematosus [ 144 ].…”

Section: Discussionmentioning

confidence: 99%

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Lung Cancer as a Leading Cause among Paraneoplastic Non-Bacterial Thrombotic Endocarditis: A Meta-Analysis of Individual Patients’ Data

Rahouma

Khairallah

Dabsha

et al. 2023

Cancers

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Hypercoagulability is strongly associated with cancer and may result in non-bacterial thrombotic endocarditis (NBTE). The aim of our meta-analysis was to explore the demographics and characteristics of this condition in cancer. Databases were systematically searched. The outcomes were to identify the annual trend in premortem diagnosis among the entire cohort and different subgroups and to identify differences in characteristics and survival in the considered population. A total of 121 studies with 144 patients were included. The proportion of marantic endocarditis associated with lung cancer was 0.29 (95% CI, 0.21–0.37; p < 0.001), that associated with pancreatic cancer was 0.19 (95% CI, 0.13–0.27; p < 0.001), that associated with advanced cancer stage (metastasis) was 0.69 (95% CI, 0.61–0.76; p < 0.001), and that associated with adenocarcinoma was 0.65 (95% CI, 0.56–0.72; p < 0.001). Median and 6-month overall survival (OS) were 1.3 months and 32.3%, respectively, with 6-month OS of 20.8% vs. 37.0% in lung vs. other cancers, respectively (p = 0.06) and 42.9% vs. 31.1% among those who underwent intervention vs. those who did not (p = 0.07). Cases discovered in recent years had better survival (HR = 0.98 (95% CI, 0.96–0.99; p = 0.003). While cancer-associated NBTE is a rare entity, lung cancers were the most common tumor site and are frequently associated with more advanced and metastatic cancer stages. The prognosis is dismal, especially among lung cancers.

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