MAPs of the neuron

Abstract

Chapter1 -Generalintroduction NEURONALDEVELOPMENT Studyneuronaldevelopmentinvitroandinvivo Featuresofneuronal polarity MICROTUBULES Microtubule assembly Microtubule basedmotorproteins Microtubule dynamics Tubulincodeandposttranslational modifications (PTMs) Microtubule associated proteins (MAPs) MICROTUBULEANDTRANSPORTINNEURON Microtubule-associated proteins (MAPs)inneuron "MAP" codecontrolsmotoractivity inneuron SCOPEOFTHISTHESIS Chapter2 -MAP7D2localizes totheproximalaxonand locallypromoteskinesin-1 mediated cargotransportintotheaxon Chapter3 -TheE3ligaseTRIMfamilymembersMID1andMID2associatewith microtubulesandcontrolneurodevelopment Chapter4 -TRIM46organizes microtubule fasciculationintheaxoninitialSegment Chapter5 -Feedback-drivenassemblyoftheaxoninitialsegment Chapter6 -Generaldiscussion Themicrotubule organization intheaxon The'MAPcodes'guideKinesin-1 mediated cargooutofdendrite LocalcontrolofKinesin-1mediatedcargotransportintheaxon Polarizeddistribution ofMAPsinneurons MechanismsofMAPsregulatingaxonbranching Futureperspective Appendix-CV/SummaryinEnglish andDutch/Acknowledgements