Maprotiline induced weight gain in depressive disorder: Changes in circulating ghrelin and adiponectin levels and insulin sensitivity

Pinar, Murat; Gülsün, Murat; Taşçı, İlker; Erdil, Ahmet; Bolu, Erol; Açıkel, Cengizhan; Doruk, Ali

doi:10.1016/j.pnpbp.2007.07.028

Cited by 39 publications

(23 citation statements)

References 32 publications

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“…The hypothesis was based on the finding that ghrelin plasma levels in depressed patients decreased with psychopathological improvement under treatment with the antidepressant mirtazapine [25] . In contrast, a recent study investigating the antidepressant maprotiline, which was comparable in terms of study duration, type and severity of symptoms, psychopathological improvement and weight gain, reported an increase in ghrelin plasma levels [30] . These contradictory findings support those from the present study, as they suggest that depressive symptoms per se do not influence ghrelin plasma levels to any relevant degree.…”

Section: Discussionmentioning

confidence: 78%

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Ghrelin Plasma Levels Are Not Altered in Major Depression

Kluge¹,

Schüssler²,

Schmid³

et al. 2009

Neuropsychobiology

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Background: In patients with major depression, the function of most endocrine axes is altered compared to healthy subjects. The orexigenic hormone ghrelin, which shows higher plasma levels in females than males, interacts with several of these endocrine axes. In addition, ghrelin levels in depressed patients decrease with psychopathological improvement. Therefore, we hypothesized that ghrelin levels in patients with major depression would be higher than in healthy subjects. Methods: Nocturnal (20:00–07:00 h) secretion patterns of ghrelin in 20 patients with major depression [11 females, age 39.4 ± 10.2 years (mean ± standard deviation); 9 males, age 38.3 ± 10.4 years] with a total score on the Hamilton Depression Rating Scale, 21-item version, of 24.8 ± 5.2 and 20 healthy subjects [11 females, age 38.7 ± 10.8 years; 9 males, age 39.1 ± 11.2 years] were determined following an adaptation night. Results: Ghrelin plasma levels of depressed patients and matched healthy subjects did not differ at any point in time when stratified for sex. Accordingly, the area under the curve was comparable: depressed females, 423.3 ± 103.4; healthy females, 398.0 ± 94.6; depressed males, 266.3 ± 56.9, and healthy males, 228.4 ± 41.3. Conclusion: This is the first comparison of ghrelin secretion patterns in patients with major depression and healthy controls. Surprisingly, no relevant differences were ascertained between the two groups.

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Section: Discussionmentioning

confidence: 78%

“…It is more likely that specific drug effects might have been involved in the changes in plasma ghrelin levels. Alternatively, it should also be taken into account that one study included only males [30] and the other predominantly females [25] . This might be of relevance, as both ghrelin plasma levels and some effects of ghrelin, e.g.…”

Section: Discussionmentioning

confidence: 99%

Ghrelin Plasma Levels Are Not Altered in Major Depression

Kluge¹,

Schüssler²,

Schmid³

et al. 2009

Neuropsychobiology

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“…Psychosocial factors may play an important role in FD, which lead to the use of antidepressant and anxiolytic agents in the management of FD [20]. A study reported antidepressant maprotiline was effective for lean patients with depressive disorder and weight gain was observed [21]. …”

Section: Discussionmentioning

confidence: 99%

The Clinical-Psychological Features of Functional Dyspepsia Patients with Weight Loss: A Multi-Center Study from China

Liu

Jia²,

Lei³

et al. 2015

Digestion

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Aims: To investigate the clinical features, appetite, quality of life (QOL), and their associated psychological factors of functional dyspepsia (FD) patients with weight loss. Methods: For a multicenter study, FD patients were recruited and divided into two groups according to the degree of weight changes during the previous 12 months or less with the onset of dyspepsia symptoms: Group A (≥5%) and Group B (<5%). Patients were evaluated based on the Nepean dyspepsia index (NDI), appetite questionnaire, Hamilton Rating Scale of Anxiety/Depression (HAMA/HAMD). Results: The body mass index in Group A was lower than in Group B, while, the frequency of physician visits in Group A was higher than in Group B. There were no differences in the total scores of NDI-symptom checklist or the items of intensity and bothersomeness between them (p > 0.05), but the frequency item for Group A was significantly higher than Group B (p = 0.035). The incidence of anxiety or depression, the proportion of poor or very poor appetite for Group A was higher than those for Group B (p < 0.05). Subscale scores of the NDI-QOL for Group A were significantly lower than those for Group B (p < 0.05). Conclusions: FD patients with weight loss have lower BMI, more frequent physician visits, higher psychological disorders, poorer appetite and QoL.

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“…This view receives some support from studies reporting that psychopathological improvement of depressed patients following electroconvulsive therapy [60] and psychopharmacological treatment [61,62] was associated with a decrease in ghrelin plasma levels. However, one study reported an increase during antidepressant medication [63]. Reports on ghrelin plasma levels in untreated depressed patients are similar [64], with conflicting findings of increased [65] and decreased [64] ghrelin plasma levels as compared to those in healthy controls.…”

Section: Discussionmentioning

confidence: 99%

“…Further studies are needed to examine the relationship between serotonin and ghrelin in central and peripheral lesions. Maprotiline induces an increase in serum ghrelin in patients with MDD [63]. Recently, nocturnal secretion concentrations of ghrelin in patients with MDD were compared with those of healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Serum Ghrelin Levels and the Effects of Antidepressants in Major Depressive Disorder and Panic Disorder

Ishitobi

Kohno²,

Kanehisa³

et al. 2012

Neuropsychobiology

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Background: Two opposing models for the action of ghrelin in the behavioral responses to stress were recently proposed. Some studies suggest that an increase in ghrelin contributes to the mechanisms responsible for the development of stress-induced depression and anxiety, while others suggest that it helps minimize what otherwise would be more severe manifestations of depression and anxiety following stress. Methods: We measured serum ghrelin levels, Profile of Mood States (POMS) scores and State-Trait Anxiety Inventory scores in nonresponders (treatment-resistant patients; 30) and responders (38) with major depressive disorder (MDD), nonresponders (29) and responders (51) with panic disorder and 97 healthy controls. Results: The ghrelin concentration in nonresponders with MDD was higher than that of responders with MDD and normal controls. The ghrelin concentration in nonresponders with panic disorder was higher than that of normal controls. POMS vigor scores in patients with MDD and panic disorder were significantly decreased compared with those in healthy controls. Other POMS scores in patients with MDD and panic disorder were significantly increased compared with those of healthy controls. Trait and state anxiety of the State-Trait Anxiety Inventory in MDD and panic disorder patients were higher than those in healthy controls. Conclusions: These results indicate that decreased serum ghrelin levels might be associated with antidepressant treatment to confer the maximum therapeutic effect in patients with MDD and panic disorder.

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Maprotiline induced weight gain in depressive disorder: Changes in circulating ghrelin and adiponectin levels and insulin sensitivity

Cited by 39 publications

References 32 publications

Ghrelin Plasma Levels Are Not Altered in Major Depression

Ghrelin Plasma Levels Are Not Altered in Major Depression

The Clinical-Psychological Features of Functional Dyspepsia Patients with Weight Loss: A Multi-Center Study from China

Serum Ghrelin Levels and the Effects of Antidepressants in Major Depressive Disorder and Panic Disorder

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