Maprotiline in the treatment of endogenous depression: Comparison of therapeutic effect with serotonin level in blood platelets

Mück‐Šeler, Dorotea; Deanović, Z; Jamnicky, Blanka; Jakupčević, M.; Mihovilović, Maja

doi:10.1007/bf00427824

Cited by 11 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Platelets have been used as a model for uptake of serotonin by synaptosomes (21). The negative correlation between serotonin in platelets and turning aggression against others, depression (DEP) and hostility (HOS) and between serotonin in plasma and tryptophan with HOS in our patient group supported the suggested coupling between aggression and depression with a low functioning serotonergic system (22,23)).…”

Section: Discussionsupporting

confidence: 82%

Panic disorder and depression: relationship between psychological and biochemical aspects

Timmerman

2003

Acta Neuropsychiatr.

View full text Add to dashboard Cite

In a group of medication-free out-patients suffering from depression and/or panic disorder we investigated the interdependence between psychological parameters such as aggression and biochemical parameters such as serotonin and tryptophan. We compared the findings in the patient group with a reference group. In the group of patients as a whole negative correlations were observed between the concentration of serotonin in platelets and depression and with hostility and aggression against others. Serotonin in plasma and tryptophan correlated negatively with hostility. The findings support the suggested link between aggression and depression with a low functioning serotonergic system.

show abstract

Section: Discussionsupporting

confidence: 82%

Panic disorder and depression: relationship between psychological and biochemical aspects

Timmerman

2003

Acta Neuropsychiatr.

View full text Add to dashboard Cite

show abstract

Urinary 3-methoxy, 4-hydroxyphenylethylene glycol and therapeutic response to maprotiline and indalpine in major depression

Benkelfat

Vanelle

et al. 1986

J. Neural Transmission

View full text Add to dashboard Cite

The potential value of pretreatment urinary 3-methoxy, 4-hydroxyphenylethyleneglycol (MHPG) levels to predict the therapeutic response to antidepressants was studied by measuring urinary MHPG output in 42 depressed inpatients treated with a selective inhibitor of serotonin (Indalpine) or noradrenaline (Maprotiline) reuptake. Among the 42 depressed inpatients there were 33 cases of major depressive episode. Patients were treated for at least 3 weeks, firstly with intravenous infusions of maprotiline or indalpine which have been administered at random. No difference in pretreatment urinary MHPG levels was found between the responders to indalpine (1.08 +/- 0.48 micrograms/24 h/mg of creatinine) and the responders to maprotiline (1.15 +/- 0.62 micrograms/24 h/mg of creatinine). However, there was a difference in the pretreatment levels of urinary MHPG between the non-responders to indalpine (0.56 +/- 0.28 microgram/24 h/mg of creatinine) and the non-responders to maprotiline (1.37 +/- 0.68 micrograms/24 h/mg of creatinine). No correlation between this biochemical parameter and HDRS score was found. These results indicate that, in this study, there is no obvious relationship between the pretreatment urinary MHPG levels in depressed patients and their therapeutic response to specific inhibitors of noradrenaline or serotonin reuptake. However, there was a positive trend towards a lower pretreatment MHPG level to be associated with lack of response to indalpine.

show abstract

Platelet research in psychiatry

Wirz‐Justice

1988

Experientia

View full text Add to dashboard Cite

The platelet is one of the most researched biological markers in psychiatry. Characteristics of MAO activity, 5-HT uptake, imipramine and alpha 2-adrenergic receptor binding, for example, are similar in platelet and CNS. Methodological factors are not negligible, and range from diagnostic specificity and drug effects to the normal physiological variability of age and hormone-related changes, circadian and seasonal rhythms. As yet, there are no clear state or trait platelet markers in affective disorders and schizophrenia that can be unequivocally used to detect vulnerability to the illness, predict therapeutic response, define clinical diagnostic entities or follow the course of the illness. However, platelet markers are increasingly being used in careful studies to monitor psychopharmacological effects (an in vivo assay of all active metabolites), different ligands can be specific markers for certain aspects of a psychiatric illness (e.g. alpha 2-adrenergic receptors and weight loss), and this homogeneous preparation of human cells is an increasingly important tool in studying mechanisms in pathophysiology. More longitudinal studies are required to establish functional relationships between platelet variables and psychopathology.

show abstract

Maprotiline in the treatment of endogenous depression: Comparison of therapeutic effect with serotonin level in blood platelets

Cited by 11 publications

References 22 publications

Panic disorder and depression: relationship between psychological and biochemical aspects

Panic disorder and depression: relationship between psychological and biochemical aspects

Urinary 3-methoxy, 4-hydroxyphenylethylene glycol and therapeutic response to maprotiline and indalpine in major depression

Platelet research in psychiatry

Contact Info

Product

Resources

About