Mapping the thickness changes on retinal layers segmented by spectral-domain optical coherence tomography using the posterior pole program in glaucoma

García-Medina, J.J.; del-Río-Vellosillo, Mónica; Palazón-Cabanes, Ana; Tudela-Molino, M.; Gómez-Molina, C.; Guardiola-Fernández, A.; Villegas–Pérez, M.P.

doi:10.1016/j.oftale.2018.04.002

Cited by 4 publications

(6 citation statements)

References 24 publications

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“…However, the thickening of the outer retinal layers found in this study affects fewer superpixels than affected in our previous study. However, in general, our present results corroborated the results found in our previous study, although in a different type of patients [16].…”

Section: Discussionsupporting

confidence: 93%

“…Previous studies on this subject have found controversial results. Some showed no thickness changes [7][8][9][10][11][12][13], while others found significant thickening of the outer macular layers consistent with the results of this work [14][15][16][17]. This disparity of results may be attributable to differences on the methods used (for example, different OCT algorithms, the 8 × 8 PPA or the ETDRS grid, as discussed above) or to the fact that glaucomatous changes in outer retina layers are much more subtle in the outer retinal layer than in the inner retinal layer and thus require a larger sample size to be detected.…”

Section: Discussionsupporting

confidence: 90%

“…However, in our daily clinical practice, one of the main dilemmas that we face is to discriminate between OHT and early POAG in order to consider the start of ocular therapy. The fact that these two evolutionary stages (OHT and early POAG) are so close may justify that the differences between groups were less intense and extensive in the present study than they were in our previous study [16].…”

Section: Discussioncontrasting

confidence: 50%

“…All these mentioned studies dealing with 8 × 8 PPA in glaucoma, except ours [16], aggregated data and did not consider individual superpixels for analysis. In our opinion, the aggregation of data makes these models lose details when trying to detect subtle changes as those of outer macular layers.…”

Section: Discussionmentioning

confidence: 99%

“…All authors agree that there is thinning of the inner retinal layers in POAG. However, controversy exists concerning the behaviour of outer retinal layers in this disease [7][8][9][10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

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Glaucomatous Maculopathy: Thickness Differences on Inner and Outer Macular Layers between Ocular Hypertension and Early Primary Open-Angle Glaucoma Using 8 × 8 Posterior Pole Algorithm of SD-OCT

García-Medina

del-Río-Vellosillo

Palazón-Cabanes

et al. 2020

JCM

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The purpose of this study was to compare the thickness of all inner and outer macular layers between ocular hypertension (OHT) and early primary open-angle glaucoma (POAG) using spectral domain optical coherence tomography (SD-OCT) 8 × 8 posterior pole algorithm (8 × 8 PPA). Fifty-seven eyes of 57 OHT individuals and fifty-seven eyes of 57 early POAG patients were included. The thickness of macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform and nuclear layer, photoreceptor layer (PRL) and retinal pigment epithelium were obtained in 64 cells for each macular layer and mean thickness of superior and inferior hemispheres was also calculated. Thinning of superior and inferior hemisphere mean thickness in mRNFL, GCL and IPL and thickening of superior and inferior hemisphere mean thickness in PRL and inferior hemisphere in INL were found in early GPAA group. Otherwise, heatmaps representing cell-to-cell comparisons showed thinning patterns in inner retinal layers (except for INL) and thickening patterns in outer retinal layers in GPAA group. We found that 8 × 8 PPA not only allows the detection of significant thinning patterns in inner retinal layers, but also thickening patterns in outer retinal layers when comparing early POAG eyes to OHT eyes.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 90%

Section: Discussioncontrasting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Glaucomatous Maculopathy: Thickness Differences on Inner and Outer Macular Layers between Ocular Hypertension and Early Primary Open-Angle Glaucoma Using 8 × 8 Posterior Pole Algorithm of SD-OCT

García-Medina

del-Río-Vellosillo

Palazón-Cabanes

et al. 2020

JCM

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The thickness of the outer retina in the macula and circumpapillary area in patients with unilateral advanced glaucoma

Vahedian

Fakhraie

Ghasemi

et al. 2022

Graefes Arch Clin Exp Ophthalmol

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Macular Anatomy Differs in Dyslexic Subjects

García-Medina

Bascuñana-Mas

Sobrado‐Calvo

et al. 2023

JCM

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The macula, as the central part of the retina, plays an important role in the reading process. However, its morphology has not been previously studied in the context of dyslexia. In this research, we compared the thickness of the fovea, parafovea and perifovea between dyslexic subjects and normal controls, in 11 retinal segmentations obtained by optical coherence tomography (OCT). With this aim, we considered the nine sectors of the Early Treatment Diabetic Retinopathy Study (ETDRS) grid and also summarized data from sectors into inner ring subfield (parafovea) and outer ring subfield (perifovea). The thickness in all the four parafoveal sectors was significantly thicker in the complete retina, inner retina and middle retina of both eyes in the dyslexic group, as well as other macular sectors (fovea and perifovea) in the inner nuclear layer (INL), inner plexiform layer (IPL), IPL + INL and outer plexiform layer + outer nuclear layer (OPL + ONL). Additionally, the inner ring subfield (parafovea), but not the outer ring subfield (perifovea), was thicker in the complete retina, inner retina, middle retina (INL + OPL + ONL), OPL + ONL, IPL + INL and INL in the dyslexic group for both eyes. In contrast, no differences were found between the groups in any of the sectors or subfields of the outer retina, retinal nerve fiber layer, ganglion cell layer or ganglion cell complex in any eye. Thus, we conclude from this exploratory research that the macular morphology differs between dyslexic and normal control subjects, as measured by OCT, especially in the parafovea at middle retinal segmentations.

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Mapping the thickness changes on retinal layers segmented by spectral-domain optical coherence tomography using the posterior pole program in glaucoma

Cited by 4 publications

References 24 publications

Glaucomatous Maculopathy: Thickness Differences on Inner and Outer Macular Layers between Ocular Hypertension and Early Primary Open-Angle Glaucoma Using 8 × 8 Posterior Pole Algorithm of SD-OCT

Glaucomatous Maculopathy: Thickness Differences on Inner and Outer Macular Layers between Ocular Hypertension and Early Primary Open-Angle Glaucoma Using 8 × 8 Posterior Pole Algorithm of SD-OCT

The thickness of the outer retina in the macula and circumpapillary area in patients with unilateral advanced glaucoma

Macular Anatomy Differs in Dyslexic Subjects

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