Mapping the spatial variation of mitral valve elastic properties using air-pulse optical coherence elastography

Vekilov, Dragoslava P.; Singh, Manmohan; Aglyamov, Salavat R.; Larin, Kirill V.; Grande‐Allen, K. Jane

doi:10.1016/j.jbiomech.2019.06.015

Cited by 6 publications

(5 citation statements)

References 39 publications

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“…These studies have also indicated that mitral valve leaflets are inhomogeneous, changing their mechanical properties going from anterior leaflet belly to the edge. 21 However, specific measurements of certain mechanical properties such as maximum physiological radial strain values experienced by mitral valves have often varied between measurement technique and tissue source, ranging between approximately 15–25% strain. 8 , 19 …”

Section: Discussionmentioning

confidence: 99%

Development of 3D Printed Mitral Valve Constructs for Transcatheter Device Modeling of Tissue and Device Deformation

et al. 2022

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Transcatheter mitral valve repair (TMVR) therapies offer a minimally invasive alternative to surgical mitral valve (MV) repair for patients with prohibitive surgical risks. Pre-procedural planning and associated medical device modeling is primarily performed in silico, which does not account for the physical interactions between the implanted TMVR device and surrounding tissue and may result in poor outcomes. We developed 3D printed tissue mimics for modeling TMVR therapies. Structural properties of the mitral annuli, leaflets, and chordae were replicated from multi-material blends. Uniaxial tensile testing was performed on the resulting composites and their mechanical properties were compared to those of their target native components. Mimics of the MV annulus printed in homogeneous strips approximated the tangent moduli of the native mitral annulus at 2% and 6% strain. Mimics of the valve leaflets printed in layers of different stiffnesses approximated the force–strain and stress–strain behavior of native MV leaflets. Finally, mimics of the chordae printed as reinforced cylinders approximated the force–strain and stress–strain behavior of native chordae. We demonstrated that multi-material 3D printing is a viable approach to the development of tissue phantoms, and that printed patient-specific geometries can approximate the local deformation force which may act upon devices used for TMVR therapies.

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Section: Discussionmentioning

confidence: 99%

Development of 3D Printed Mitral Valve Constructs for Transcatheter Device Modeling of Tissue and Device Deformation

et al. 2022

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“…The application of wave-based OCE has also been instrumental in the study of other ex vivo tissues, including skin elastography using air-pulse [103] and laser-based [113] stimulation; the study of cardiac tissues under normal conditions [104] and myocardial infarction [105,106], heart valves [189], uterus [190], liver [52,123], brain [76,191], cartilage [107], soft tumors [93], skeletal muscle [61], diaphragm muscle [24], and breast [192] tissues. Besides the study of ocular tissues, skin elastography has been of major interest in wave-based OCE since the imaging resolution of OCT implementations is capable of resolving tissue layers such as epidermis, dermis, and hypodermis with great detail compared to other imaging modalities.…”

Section: Other Tissuesmentioning

confidence: 99%

Wave-based optical coherence elastography: the 10-year perspective

Zvietcovich

Larin

2022

Prog. Biomed. Eng.

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After ten years of progress and innovation, optical coherence elastography (OCE) based on the propagation of mechanical waves has become one of the major and, perhaps, one of the most studied OCE branches, producing a fundamental impact in the quantitative and nondestructive biomechanical characterization of tissues. Preceding previous progress made in ultrasound and magnetic resonance elastography; wave-based OCE has pushed to the limit the advance of three major pillars: (1) implementation of novel wave excitation methods in tissues, (2) understanding new types of mechanical waves in complex boundary conditions by proposing advance analytical and numerical models, and (3) the development of novel estimators capable of retrieving quantitative 2D/3D biomechanical information of tissues. This remarkable progress promoted a major advance in answering basic science questions and improving medical disease diagnosis and treatment monitoring in several types of tissues leading, ultimately, to the first attempts of clinical trials and translational research. This paper summarizes the fundamental up-to-date principles and categories of wave-based OCE, revises the timeline and the state-of-the-art techniques and applications lying in those categories, and concludes with a discussion of current challenges and future directions, including clinical translation research.

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“…The air-puff system has the unique advantage of a non-contact nature; it is widely used in clinical applications, particularly in the fields of ophthalmology [11,34], soft tissue [29,35,36] and cardiology [37]. Even though there are a limited number of studies about the applications of air-puff system-based tissue stiffness measurements, the excitation distance, excitation angle and excitation pressure of air-puff system all affect the amplitude of SAWs [28].…”

Section: Introductionmentioning

confidence: 99%

“…One research that could achieve the optical beam was collinear with the direction of the air-puff to allow the light to pass the commercial non-contact tonometer chamber through an optical window [44]. Some research applied the air-puff in the applications without mentioning any description and details about excitation angle [11,[34][35][36][37][45][46][47][48][49].…”

Section: Introductionmentioning

confidence: 99%

Effects of Excitation Angle on Air-Puff-Stimulated Surface Acoustic Wave-Based Optical Coherence Elastography (SAW-OCE)

Feng,

Zhang,

Jiang

et al. 2024

Photonics

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Increased stiffness of tissues has been recognised as a diagnostic feature of pathologies. Tissue stiffness characterisation usually involves the detection of tissue response from mechanical stimulation. Air-puff optical coherence elastography (OCE) can generate impulse surface acoustic waves (SAWs) on tissue surface without contact and evaluate the mechanical properties of tissue. This study endeavours to explore the optimal excitation angle for air-puff OCE, a parameter that lacks standardisation at present, by investigating the relationship between the frequency bandwidth and peak-to-peak signal-to-noise ratio (SNR) of SAWs for different excitation angles (relative to the normal surface) of air-puff on the sample, from 5° to 85°, with an interval of 5° applied on the phantom. Due to the unevenness of human hands, 20°, 45° and 70° angles were employed for human skin (10 healthy adults). The results show that a smaller excitation angle could produce higher wave frequency bandwidth; a 5° angle generated an SAW with 1747 Hz frequency bandwidth, while an 85° angle produced an SAW with 1205 Hz. Significant differences were not shown in peak-to-peak SNR comparison between 5° and 65° on the phantom, but between 65° and 85° at the excitation position, a reduction of 48.6% was observed. Furthermore, the group velocity of the SAWs was used to evaluate the bulk Young’s modulus of the human tissue. The outcomes could provide essential guidance for air-puff-based elastography studies in clinical applications and future tissue research.

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Mapping the spatial variation of mitral valve elastic properties using air-pulse optical coherence elastography

Cited by 6 publications

References 39 publications

Development of 3D Printed Mitral Valve Constructs for Transcatheter Device Modeling of Tissue and Device Deformation

Development of 3D Printed Mitral Valve Constructs for Transcatheter Device Modeling of Tissue and Device Deformation

Wave-based optical coherence elastography: the 10-year perspective

Effects of Excitation Angle on Air-Puff-Stimulated Surface Acoustic Wave-Based Optical Coherence Elastography (SAW-OCE)

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