Mapping the Research of Ferroptosis in Parkinson’s Disease from 2013 to 2023: A Scientometric Review

Abstract

Methods Related studies on PD and ferroptosis were searched in Web of Science Core Collection (WOSCC) from inception to 2023. VOSviewer, CiteSpace, RStudio, and Scimago Graphica were employed as bibliometric analysis tools to generate network maps about the collaborations between authors, countries, and institutions and to visualize the co-occurrence and trends of co-cited references and keywords. Results A total of 160 original articles and reviews related to PD and ferroptosis were retrieved, produced by from 958 authors from 162 institutions. Devos David was the most prolific author, with 9 articles. China and the University of Melbourne had leading positions in publication volume with 84 and 12 publications, respectively. Current hot topics focus on excavating potential new targets for treating PD based on ferroptosis by gaining insight into specific molecular mechanisms, including iron metabolism disorders, lipid peroxidation, and imbalanced antioxidant regulation. Clinical studies aimed at treating PD by targeting ferroptosis remain in their preliminary stages. Conclusion A continued increase was shown in the literature within the related field over the past decade. The current study suggested active collaborations among authors, countries, and institutions. Research into the pathogenesis and treatment of PD based on ferroptosis has remained a prominent topic in the field in recent years, indicating that ferroptosis-targeted therapy is a potential approach to halting the progression of PD.

The research landscape of ferroptosis in neurodegenerative disease: a bibliometric analysis

“…Current bibliometric analyses on ferroptosis primarily concentrate on specific diseases within the ND series, such as PD and AD. Researchers have identified pathogenesis and treatment ( Chen et al, 2024 ) as key areas of interest in PD research, with ‘ferroptosis,’ ‘immunohistochemistry,’ ‘diagnosis,’ and ‘microenvironment’ being highlighted as frequent keywords ( Lu et al, 2023 ). Similarly, in AD research, the focus lies on molecular mechanisms ( Liu et al, 2024b ), with ‘Ferroptosis in AD,’ ‘Pyrptosis in AD,’ and ‘Neoptosis in AD’ emerging as cutting-edge terms that indicate the present and future research directions in this field ( Yeerlan et al, 2024 ).…”