Mapping the medullar adiposity of lumbar spine in MRI: A feasibility study

Demany, N; Mesrar, Jawad; Aho-Glélé, Ludwig S.; Saraux, Alain; Salem, Douraı̈ed Ben

doi:10.1016/j.heliyon.2021.e05992

Cited by 5 publications

(4 citation statements)

References 20 publications

(27 reference statements)

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“…We found that the median FF was numerically higher among men than women (0.44 versus 0.39). In a study of lumbar vertebral marrow fat distribution in 46 healthy adults (women, n = 21; men, n = 25; aged 18–77 years), FF was significantly higher for men than for women (mean [SD], 39.5% [12.2] vs. 35.9% [13.9]; p < 0.001) and for postmenopausal women than for premenopausal women (mean [SD], 44.5% [17.0] vs. 29.6% [7.8]; p < 0.001) using univariate regression [ 23 ]. However, only age had a significant effect on FF by vertebral level in multivariate regression analysis using a robust variance estimator ( p = 0.003; β = 0.52; standard deviation 0.18).…”

Section: Discussionmentioning

confidence: 99%

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The Bone Biomarker of Quantitative Chemical Shift Imaging in Patients with Type 1 Gaucher Disease Receiving Low-Dose Long-Term Enzyme Replacement Therapy

Zimran

Szer

Becker‐Cohen

et al. 2023

JCM

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Quantitative chemical shift imaging (QCSI) is the most sensitive imaging biomarker to assess bone marrow involvement in Gaucher disease. Widespread QCSI use is limited by test availability. Anecdotal reports describe two patients demonstrating significant improvement in fat fraction (FF) assessed by QCSI following a switch from imiglucerase to taliglucerase alfa. This analysis evaluated bone marrow involvement in adults with Type 1 Gaucher disease receiving low-dose enzyme replacement therapy (ERT) with imiglucerase and/or velaglucerase alfa. We report baseline data for 30 patients meeting eligibility criteria. Median (range) duration and dose of ERT were 18 (5–26) years and 30 (30–60) U/kg/month, respectively. Low FF scores (<0.30) were observed for seven patients (23%; 95% confidence interval, 10–42%) and were more common in females (n = 6) versus males (n = 1; p < 0.025); one female was menopausal. These baseline data demonstrate that prolonged low-dose ERT with imiglucerase or velaglucerase alfa led to an adequate bone response, assessed by QCSI, in the majority of patients. A minority of such patients with suboptimal bone response require therapeutic change. The next phase of the study will address the effect of switching to taliglucerase alfa on bone status for patients with less than optimal QCSI scores (<0.30).

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Section: Discussionmentioning

confidence: 99%

“…However, only age had a significant effect on FF by vertebral level in multivariate regression analysis using a robust variance estimator ( p = 0.003; β = 0.52; standard deviation 0.18). Other independent variables (body mass index, weight, and height) had no significant effect on either univariate or multivariate analysis [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

The Bone Biomarker of Quantitative Chemical Shift Imaging in Patients with Type 1 Gaucher Disease Receiving Low-Dose Long-Term Enzyme Replacement Therapy

Zimran

Szer

Becker‐Cohen

et al. 2023

JCM

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“…Several previous studies on vertebral BMF have found that BMF grows progressively higher at lower vertebral levels [ 19 , 20 ]. The results of the present study were similar, indicating that this pattern applies consistently to different spinal types.…”

Section: Discussionmentioning

confidence: 99%

Associations between vertebral bone marrow fat and sagittal spine alignment as assessed by chemical shift-encoding-based water–fat MRI

et al. 2023

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Background The relationship between sagittal spine alignment and vertebral bone marrow fat is unknown. We aimed to assess the relationship between vertebral bone marrow fat and sagittal spine alignment using chemical shift-encoding-based water–fat magnetic resonance imaging (MRI). Methods A total of 181 asymptomatic volunteers were recruited for whole spine X-ray and lumbar MRI. Spine typing was performed according to the Roussouly classification and measurement of vertebral fat fraction based on the chemical shift-encoding-based water–fat MRI. One-way analysis of variance (ANOVA) was used to analyze the differences in vertebral fat fraction between spine types. The post hoc least significant difference (LSD) test was utilized for subgroup comparison after ANOVA. Results Overall, the vertebral fat fraction increased from L1 to L5 and was the same for each spine type. The vertebral fat fraction was the highest in type 1 and lowest in type 4 at all levels. ANOVA revealed statistically significant differences in fat fraction among different spine types at L4 and L5 (P < .05). The post hoc LSD test showed that the fat fraction of L4 was significantly different (P < .05) between type 1 and type 4 as well as between type 2 and type 4. The fat fraction of L5 was significantly different between type 1 and type 3, between type 1 and type 4, and between type 2 and type 4 (P < .05). Conclusion Our study found that vertebral bone marrow fat is associated with sagittal spine alignment, which may serve as a new additional explanation for the association of sagittal alignment with spinal degeneration.

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“…In this study, we used the L1 and L2 vertebral bodies for BMAT-FF measurements. These levels may not be representative of the entire lumbar spine, as previous studies found differences in vertebral bone marrow fat fractions with an increase of BMAT-FF in the craniocaudal direction [13,52]. Yet, considering that the lower lumbar spine (L3-L5) usually is the level of most severe degenerations and the described craniocaudal increase of BMAT-FF in lumbar vertebrae, it may be speculated that the effects reported in our study are rather conservative estimates of the association between lumbar spine BMAT-FF and IVDD.…”

Section: Discussionmentioning

confidence: 99%

Association of lumbar vertebral bone marrow and paraspinal muscle fat composition with intervertebral disc degeneration: 3T quantitative MRI findings from the population-based KORA study

et al. 2022

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Objective To assess the association of lumbar bone marrow adipose tissue fat fraction (BMAT-FF) and paraspinal muscle proton density fat fraction (PDFF) and their interplay with intervertebral disc degeneration (IVDD). Methods In this retrospective cross-sectional study based on a prospective population-based cohort, BMAT-FF and PDFF of asymptomatic individuals were calculated based on 3T-MRI dual-echo and multi-echo Dixon VIBE sequences. IVDD was assessed at motion segments L1 to L5 and dichotomized based on Pfirrmann grade ≥ 4 and/or presence of other severe degenerative changes or spinal abnormalities at least at one segment. Pearson’s correlation coefficients were calculated for BMAT-FF and PDFF. Univariable and multivariable logistic regression models for IVDD were calculated. Results Among 335 participants (mean age: 56.2 ± 9.0 years, 43.3% female), the average BMI was 27.7 ± 4.5 kg/m2 and the prevalence of IVDD was high (69.9%). BMAT-FF and PDFF were significantly correlated (r = 0.31–0.34; p < 0.001). The risk for IVDD increased with higher PDFF (OR = 1.45; CI 1.03, 2.04) and BMAT-FF (OR = 1.56; CI 1.16, 2.11). Pairwise combinations of PDFF and BMAT-FF quartiles revealed a lower risk for IVDD in individuals in the lowest BMAT-FF and PDFF quartile (OR = 0.21; CI 0.1, 0.48). Individuals in the highest BMAT-FF and PDFF quartile showed an increased risk for IVDD (OR = 5.12; CI 1.17, 22.34) Conclusion Lumbar BMAT-FF and paraspinal muscle PDFF are correlated and represent both independent and additive risk factors for IVDD. Quantitative MRI measurements of paraspinal myosteatosis and vertebral bone marrow fatty infiltration may serve as imaging biomarkers to assess the individual risk for IVDD. Key Points • Fat composition of the lumbar vertebral bone marrow is positively correlated with paraspinal skeletal muscle fat. • Higher fat-fractions of lumbar vertebral bone marrow and paraspinal muscle are both independent as well as additive risk factors for intervertebral disc degeneration. • Quantitative magnetic resonance imaging measurements of bone marrow and paraspinal muscle may serve as imaging biomarkers for intervertebral disc degeneration.

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Mapping the medullar adiposity of lumbar spine in MRI: A feasibility study

Cited by 5 publications

References 20 publications

The Bone Biomarker of Quantitative Chemical Shift Imaging in Patients with Type 1 Gaucher Disease Receiving Low-Dose Long-Term Enzyme Replacement Therapy

The Bone Biomarker of Quantitative Chemical Shift Imaging in Patients with Type 1 Gaucher Disease Receiving Low-Dose Long-Term Enzyme Replacement Therapy

Associations between vertebral bone marrow fat and sagittal spine alignment as assessed by chemical shift-encoding-based water–fat MRI

Association of lumbar vertebral bone marrow and paraspinal muscle fat composition with intervertebral disc degeneration: 3T quantitative MRI findings from the population-based KORA study

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