Abstract:The discovery that alpha-synuclein, an intrinsically disordered protein, was linked to a multitude of neurodegenerative diseases (''synucleinopathies'') prompted intense efforts to understand the function of alpha-synuclein. While many hypotheses centrally involve the ability of alpha-synuclein to bind to highly-curved lipid membranes, it is difficult to reconcile the diversity of sub-neuronal organelles (and corresponding lipid membranes) with which alpha-synuclein is purported to interact. To that end, we ha… Show more
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