The USA's Protecting Life in Global Health Assistance policy (PLGHA) is an expansion of the Mexico City Policy (MCP), which prohibited foreign NGOs that provide termination-of-pregnancy (TOP) services or actively promote TOP as a family-planning method from receiving US federal funding for family planning programmes. The expanded programme came into global effect in 2017. [1-7] PLGHA affects a number of major US funding agencies responsible for providing the majority of foreign health assistance to sub-Saharan Africa. [5,8] PLGHA proscribes TOP and TOP-related services, including counselling, referrals or lobbying, with only rare exceptions, and extends to global health assistance programmes that include HIV/AIDs programmes-unlike MCP, which was limited to family-planning assistance. [6] Ostensibly, HIV/AIDS programmes would not be affected by PLGHA, since HIV/AIDS NGOs are not TOP providers. However, numerous HIV/AIDS programmes provide information on sexual and reproductive healthcare that may include TOP-related services or activities prohibited by PLGHA. South Africa (SA) is shouldering the highest HIV burden in the world, and many South Africans rely on treatment programmes provided by SA HIV/AIDS NGOs. The majority of funding received by these NGOs to support HIV/AIDS programmes is funded by the US government. [9,10] Consequently, SA HIV/AIDS NGOs receiving US foreign assistance are required to comply with PLGHA in order to continue to receive funding for their HIV/AIDS programmes. This article explains PLGHA and how it might affect funding for HIV/AIDS in SA by illustrating how certain programmes and activities of HIV/AIDS NGOs can violate the provisions of PLGHA, and suggests ways in which such NGOs can prevent jeopardising their funding. The Mexico City Policy The MCP was instituted by the Reagan administration in 1984, during President Reagan's visit to the second International Conference on Population in Mexico City. [1,2] MCP was founded on the obligation to legally safeguard the life of a child 'before it is born as well as after birth' , as enshrined in the United Nations' Declaration of the Rights of the Child. [3] The principle objective of MCP was to promote the adoption of 'sound economic policies and where appropriate, population policies consistent with respect for human life and family values' in developing countries. [2] US support for family planning programmes is predicated on safeguarding and upholding human life and human dignity, and supporting families. [2] The USA at the time deemed TOP unacceptable, rejecting its use as a conventional family planning method. [2] Accordingly, NGOs that either provided or actively endorsed TOP were precluded from receiving any family planning funding from the US government. [2] Since its implementation 35 years ago, MCP has been rescinded and reinstated several times, but been in effect for at least 18 years.