Mapping the human brain proteome: opportunities, challenges, and clinical potential

Cartas-Cejudo, Paz; Cortés, Adriana; Lachén-Montes, Mercedes; Anaya-Cubero, Elena; Peral, Erika; Ausín, Karina; Díaz-Peña, Ramón; Fernández-Irigoyen, Joaquín; Santamaría, Enrique

doi:10.1080/14789450.2024.2313073

Cited by 2 publications

(1 citation statement)

References 139 publications

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“…A proteoform study using a quantitative proteotyping approach of the OB and OT in ASL subjects evidenced that the over-production of the olfactory marker protein (OMP) points out an imbalance in the olfactory signal transduction in ALS. Accompanying the specific over-expression of the glial fibrillary acidic protein and Bcl-xL in OT, a puzzled disruption of signaling routes was evidenced across the OB–OT axis in ALS [ 55 ]. Furthermore, deregulated proteins were mapped in cell–cell contact zones and ciliary basal bodies, potentially regulated by STAT3 and involved in IL-18 signaling and complement systems, RAS processing, and amoebiasis [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

Proteoform Analysis of the Human Olfactory System: A Window into Neurodegenerative Diseases

Rusi,

Pennacchia,

Ruqa

et al. 2024

Proteomes

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Background: Very little is known about the proteome of the human olfactory system and how diseases associated with olfactory dysfunctions can affect it. With this review, we try to summarize the existing literature on the use of this technique for a better understanding of the neurodegenerative disease process. Methods: We used the PubMed database and found different articles which were then selected independently by three authors. Results: We found 157 articles, of which, after careful selection, only 30 were analyzed in this review. We presented all the associations identified between the protein/pathway alterations neurodegenerative diseases and SARS-CoV-2 infection. Conclusions: We think that the proteome of the olfactory system through blood, saliva, and mucus analysis could be a new way to better understand, diagnose, and finally treat neurodegenerative diseases.

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Section: Resultsmentioning

confidence: 99%