Mapping the history and current situation of research on John Cunningham virus – a bibliometric analysis

Zheng, Haixue; Yan, Lei; Cui, Lei; Guan, Yifu; Takano, Yasuo

doi:10.1186/1471-2334-9-28

Cited by 36 publications

(47 citation statements)

References 22 publications

(22 reference statements)

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“…Journal articles were the most commonly retrieved document type (≈90%), similar to other bibliometric studies [8][9][10] . Although controlled trials offer the best evidence for the efficacy of medical interventions 25 , in this study they represented only 0.5% of the documents, a lower figure than in other fields 8,9 .…”

Section: Discussionmentioning

confidence: 60%

“…The increase in American trypanosomiasis publications seems to be less pronounced than that observed in other diseases and conditions, such as John Cunningham virus or obesity 9,10 . This is probably related to the decrease in the prevalence of American trypanosomiasis over the past years and the fact that this disease mostly affects developing countries in Central and South America 2 , which have low expenditures on scientific investigation 12 .…”

Section: Discussionmentioning

confidence: 86%

“…The analysis of the research production of South America and the Caribbean showed that Brazil was the leading country in publication output on Chagas disease, as has also been described in other biomedical fields [8][9][10] , followed by Argentina. Brazil, a country with a moderate prevalence of Chagas disease, led in scientific production on Chagas disease research after adjusting for estimated cases of T. cruzi infection behind after Panama and Chile.…”

Section: Discussionmentioning

confidence: 99%

“…Nucleus journals (those with high productivity) usually contain the articles with the highest impact in the area, and thus, subscriptions to such journals by indexing and abstracting services would be justified scientifically 10,6 Latin America and the Caribbean was the leading area in scientific production on American trypanosomiasis. This was an expected finding since most people with T. cruzi infection live in this area 2,22,24 .…”

Section: Discussionmentioning

confidence: 99%

“…There are inter nat ional b i bl iometr ic studies in different fields of medicine and/or different diseases [8][9][10] . There have been recent publications analyzing the research production in parasitology 11,12 , malaria 13 , and tropical medicine 14 , and bibliometric analyses of research published in Tropical Medicine and International Health 15 2,861 1940-1944 1945-1949 1950-1954 1955-1959 1960-1964 1965-1969 1970-1974 1975-1979 1980-1984 1985-1989 1990-1994 1995-1999 2000-2004 2005-2009 Number of publica�ons…”

Section: Introductionmentioning

confidence: 99%

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Mapping of Chagas disease research: analysis of publications in the period between 1940 and 2009

Ramos

González‐Alcaide

Gascón

et al. 2011

Rev. Soc. Bras. Med. Trop.

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INTRODUCTION: Publications are often used as a measure of success in research work. Chagas disease occurs in Central and Southern America. However, during the past years, the disease has been occurring outside Latin America due to migration from endemic zones. This article describes a bibliometric review of the literature on Chagas disease research indexed in PubMed during a 70-year period. METHODS: Medline was used via the PubMed online service of the U.S. National Library of Medicine from 1940 to 2009. The search strategy was: Chagas disease [MeSH] OR Trypanosoma cruzi [MeSH]. RESULTS: A total of 13,989 references were retrieved. The number of publications increased steadily over time from 1,361 (1940-1969) to 5,430 (2000-2009) (coefficient of determination for linear fit, R²=0.910). Eight journals contained 25% of the Chagas disease literature. Of the publications, 64.2% came from endemic countries. Brazil was the predominant country (37%), followed by the United States (17.6%) and Argentina (14%). The ranking in production changed when the number of publications was normalized by estimated cases of Chagas disease (Panama and Uruguay), population (Argentina and Uruguay), and gross domestic product (Bolivia and Brazil). CONCLUSIONS: Several Latin American countries, where the prevalence of T. cruzi infection was not very high, were the main producers of the Chagas disease literature, after adjusting for economic and population indexes. The countries with more estimated cases of Chagas disease produced less research on Chagas disease than some developed countries.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Mapping of Chagas disease research: analysis of publications in the period between 1940 and 2009

Ramos

González‐Alcaide

Gascón

et al. 2011

Rev. Soc. Bras. Med. Trop.

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The potential oncogenic effect of tissue-specific expression of JC polyoma T antigen in digestive epithelial cells

Zheng

Xue

Sun³

et al. 2023

Transgenic Res

Self Cite

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JC polyoma virus (JCPyV), a ubiquitous polyoma virus that commonly infects people, is identified as the etiologic factor for progressive multifocal leukoencephalopathy and has been closely linked to various human cancers. Transgenic mice of CAG-loxp-Laz-loxp T antigen were established. T-antigen expression was specifically activated in gastroenterological target cells with a LacZ deletion using a cre-loxp system. Gastric poorly-differentiated carcinoma was observed in T antigen-activated mice using K19-cre (stem-like cells) and PGC-cre (chief cells), but not Atp4b-cre (parietal cells) or Capn8-cre (pit cells) mice. Spontaneous hepatocellular and colorectal cancers developed in Alb-cre (hepatocytes)/T antigen and villin-cre (intestinal cells)/T antigen transgenic mice respectively. Gastric, colorectal, and breast cancers were observed in PGC-cre/T antigen mice. Pancreatic insulinoma and ductal adenocarcinoma, gastric adenoma, and duodenal cancer were detected in Pdx1-cre/T antigen mice. Alternative splicing of T antigen mRNA occurred in all target organs of these transgenic mice. Our findings suggest that JCPyV T antigen might contribute to gastroenterological carcinogenesis with respect to cell specificity. Such spontaneous tumor models provide good tools for investigating the oncogenic roles of T antigen in cancers of the digestive system.

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Immune suppression of JC virus gene expression is mediated by SRSF1

et al. 2016

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Progressive multifocal leukoemcephalopathy (PML) is a fatal demyelinating disease caused by the human neurotropic JC virus (JCV). JCV infects the majority of the human population during childhood and establishes a latent/persistent life-long infection. The virus reactivates under immunosuppressive conditions by unknown mechanisms, resulting in productive infection of oligodendrocytes in the central nervous system (CNS). Given the fact that the natural occurrence of PML is strongly associated with immunosuppression, the functional and molecular interaction between glial cells and neuroimmune signaling mediated by soluble immune mediators is likely to play a major role in reactivation of JCV and the progression of the lytic viral life cycle leading to the development of PML. In order to explore the effect of soluble immune mediators secreted by peripheral blood mononuclear cells (PBMCs) on JCV transcription, primary human fetal glial (PHFG) cells were treated with conditioned media from PBMCs. We observed a strong suppression of JCV early as well as late gene transcription in cells treated with conditioned media from induced PBMCs. Using a variety of virological and molecular biological approaches, we demonstrate that immune mediators secreted by PBMCs induce the expression of SRSF1, a strong inhibitor of JCV gene expression, and inhibit the replication of JCV. Our results show that down-regulation of SRSF1 in glial cells overcomes the suppression of JCV gene expression and its replication mediated by soluble immune mediators. These findings suggest the presence of a novel immune signaling pathway between glial cells and PBMCs that may control JCV gene expression during the course of viral reactivation.

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Mapping the history and current situation of research on John Cunningham virus – a bibliometric analysis

Cited by 36 publications

References 22 publications

Mapping of Chagas disease research: analysis of publications in the period between 1940 and 2009

Mapping of Chagas disease research: analysis of publications in the period between 1940 and 2009

The potential oncogenic effect of tissue-specific expression of JC polyoma T antigen in digestive epithelial cells

Immune suppression of JC virus gene expression is mediated by SRSF1

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