Mapping the EORTC QLQ-C30 and QLQ-H&amp;N35 to the EQ-5D for head and neck cancer: Can disease-specific utilities be obtained?

Health Qual Life Outcomes

Sidey-Gibbons

et al. 2020

Background EQ-5D health state utilities (HSU) are commonly used in health economics to compute quality-adjusted life years (QALYs). The EQ-5D, which is country-specific, can be derived directly or by mapping from self-reported health-related quality of life (HRQoL) scales such as the PROMIS-29 profile. The PROMIS-29 from the Patient Reported Outcome Measures Information System is a comprehensive assessment of self-reported health with excellent psychometric properties. We sought to find optimal models predicting the EQ-5D-5L crosswalk from the PROMIS-29 in the United Kingdom, France, and Germany and compared the prediction performances with that of a US model. Methods We collected EQ-5D-5L and PROMIS-29 profiles and three samples representative of the general populations in the UK (n = 1509), France (n = 1501), and Germany (n = 1502). We used stepwise regression with backward selection to find the best models to predict the EQ-5D-5L crosswalk from all seven PROMIS-29 domains. We investigated the agreement between the observed and predicted EQ-5D-5L crosswalk in all three countries using various indices for the prediction performance, including Bland–Altman plots to examine the performance along the HSU continuum. Results The EQ-5D-5L crosswalk was best predicted in France (nRMSEFRA = 0.075, nMAEFRA = 0.052), followed by the UK (nRMSEUK = 0.076, nMAEUK = 0.053) and Germany (nRMSEGER = 0.079, nMAEGER = 0.051). The Bland–Altman plots show that the inclusion of higher-order effects reduced the overprediction of low HSU scores. Conclusions Our models provide a valid method to predict the EQ-5D-5L crosswalk from the PROMIS-29 for the UK, France, and Germany.

Section: Summary Of Main Findingssupporting

confidence: 80%

Predicting EQ-5D-5L crosswalk from the PROMIS-29 profile for the United Kingdom, France, and Germany

Health Qual Life Outcomes

Sidey-Gibbons

et al. 2020

“…The EQ-5D index value can therefore now be predicted from the PROMIS-29 in three major European countries for use in economic evaluations of health interventions. Our results in terms of the RMSE and MAE are well within the limits of what is usually reported for mapping algorithms (13,(36)(37)(38)(39)(40). The global underestimation of the predicted EQ-5D values in OLS has also been reported in dialysis patients (41).…”

Section: Optimal Models For Predicting Health Utility In the Three Cosupporting

confidence: 89%

Predicting EQ-5D Index Scores from the PROMIS-29 Profile for the United Kingdom, France, and Germany

Gibbons

et al. 2020

Preprint

Background: EQ-5D health utility (HU) scores are commonly used in health economics to compute quality-adjusted life years (QALYs). EQ-5D scores, which are country-specific, can be derived directly or by mapping from self-reported health-related quality of life (HRQoL) scales such as the PROMIS-29 profile. The PROMIS-29 from the Patient Reported Outcome Measures Information System is a comprehensive assessment of self-reported health with excellent psychometric properties. We sought to find optimal models for predicting EQ-5D scores from the PROMIS-29 in the United Kingdom, France, and Germany and compared the prediction performances with that of a US model.Methods: We collected EQ-5D-5L and PROMIS-29 profiles and three samples representative of the general populations in the UK (n=1,509), France (n=1,501), and Germany (n=1,502). We used stepwise regression with backward selection to find the best models to predict the EQ-5D score from all seven PROMIS-29 domains. We investigated the agreement between the observed and predicted EQ-5D scores in all three countries using various indices for the prediction performance, including Bland-Altman plots to examine the performance along the HU continuum.Results:The EQ-5D index scores were best predicted in Germany (RMSEGER = 0.10, MAEGER = 0.06), followed by France (RMSEFR = 0.11, MAEFR = 0.08) and the UK (RMSEUK = 0.12, MAEUK = 0.09). The Bland-Altman plots show that the inclusion of higher-order effects reduced the underprediction of low HU scores.Conclusions: Our models provide a valid method to predict EQ-5D-5L index scores from the PROMIS-29 for the UK, France, and Germany.

Section: Summary Of Main Ndingssupporting

confidence: 80%

Predicting EQ-5D-5L crosswalk from the PROMIS-29 profile for the United Kingdom, France, and Germany

Sidey-Gibbons

et al. 2020

Preprint

Background: EQ-5D health state utilities (HSU) are commonly used in health economics to compute quality-adjusted life years (QALYs). The EQ-5D, which is country-specific, can be derived directly or by mapping from self-reported health-related quality of life (HRQoL) scales such as the PROMIS-29 profile. The PROMIS-29 from the Patient Reported Outcome Measures Information System is a comprehensive assessment of self-reported health with excellent psychometric properties. We sought to find optimal models predicting the EQ-5D-5L crosswalk from the PROMIS-29 in the United Kingdom, France, and Germany and compared the prediction performances with that of a US model.Methods: We collected EQ-5D-5L and PROMIS-29 profiles and three samples representative of the general populations in the UK (n=1,509), France (n=1,501), and Germany (n=1,502). We used stepwise regression with backward selection to find the best models to predict the EQ-5D-5L crosswalk from all seven PROMIS-29 domains. We investigated the agreement between the observed and predicted EQ-5D-5L crosswalk in all three countries using various indices for the prediction performance, including Bland-Altman plots to examine the performance along the HSU continuum.Results: The EQ-5D-5L crosswalk was best predicted in France (nRMSEFRA = 0.075, nMAEFRA = 0.052), followed by the UK (nRMSEUK = 0.076, nMAEUK = 0.053) and Germany (nRMSEGER = 0.079, nMAEGER = 0.051). The Bland-Altman plots show that the inclusion of higher-order effects reduced the overprediction of low HSU scores.Conclusions: Our models provide a valid method to predict the EQ-5D-5L crosswalk from the PROMIS-29 for the UK, France, and Germany.