Mapping the developmental potential of mouse inner ear organoids at single-cell resolution
Joerg Waldhaus,
Linghua Jiang,
Liqian Liu
et al.
Abstract:SummaryInner ear organoids recapitulate development and are intended to generate cell types of the otic lineage for applications such as basic science research and cell replacement strategies. Here, we use single-cell sequencing to study the cellular heterogeneity of late-stage mouse inner ear organoid sensory epithelia, which we validated by comparison with data sets of the mouse cochlea and vestibular epithelia. We resolved supporting cell sub-types, cochlear like hair cells, and vestibular Type I and Type I… Show more
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