Mapping the Cardiac Troponin T Linker Region to Actin and Determining Pathogenic Point Mutational Effects

Deranek, Andrea E.; Baldo, Anthony P.; Schwartz, Steven D.; Tardiff, Jil C.

doi:10.1016/j.bpj.2020.11.1627

Cited by 1 publication

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“…In the early stage of sepsis, microorganisms can invade the body, macrophages and neutrophils can move to the inflammatory site, and increase free radicals, promoting oxidative stress response. Studies have shown that septic mice have obvious oxidative stress response, and the oxidative stress of the liver, kidney, and other tissues of mice with low 5-HT level is significantly reduced [ 18 , 19 ]. This suggests that 5-HT may aggravate sepsis by promoting inflammatory and oxidative stress responses.…”

Section: Related Workmentioning

confidence: 99%

[Retracted] Analysis of the Predictive Effect of Lactic Acid Combined with Cardiac Troponin T and 5‐Hydroxytryptophan on the Severity of Sepsis in ICU Patients and Its Correlation with Prognosis

Jiang

Wang

et al. 2022

Contrast Media & Molecular Imaging

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In order to explore the effective markers of presepsis in the prediction of clinical disease and disease severity, the predictive effect of lactic acid (Lac) combined with cardiac troponin T (cTnT) and 5-hydroxytryptophan (5-HT) on the severity of sepsis in intensive care unit (ICU) patients and its correlation with prognosis is investigated. A total of 85 sepsis patients admitted to the ICU of our hospital from January 2020 to June 2021 are selected to establish the ICU sepsis group, and 72 health examination patients who received physical examination in our hospital during the same period are included in the healthy control group. The experimental results demonstrate that combined detection mode of serum Lac, cTnT, and 5-HT indicators has a high predictive value for the condition of patients with ICU sepsis and those indicators are closely correlated with the prognosis of patients. It suggests that the follow-up clinical monitoring of serum Lac, cTnT, and 5-HT indicators for patients with ICU sepsis can evaluate their condition and improve and optimize the clinical diagnosis and treatment plan effectively.

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Section: Related Workmentioning

confidence: 99%