Mapping the 3D remodeling of the extracellular matrix in human hypertrophic scar by multi-parametric multiphoton imaging using endogenous contrast

Jiang, Shenyi; Qian, Shuhao; Zhou, Lingxi; Meng, Jia; Jiang, Rushan; Wang, Chuncheng; Fang, Xinguo; Yang, Chunxu; Ding, Zhihua; Zhuo, Shuangmu; Liu, Zhiyi

doi:10.1016/j.heliyon.2023.e13653

Cited by 3 publications

(2 citation statements)

References 80 publications

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“…An excessive mechanical stimulus, compared to the perceptive capacity of the tissue, will create a chronic pathological scar environment [ 13 , 22 ]. Hypertrophic scars have vertically organized blood vessels, with highly disorganized collagen bundles in the dermal layer; the amount of Myo is clearly higher than a non-pathological scar [ 30 , 37 ]. The nodules present in hypertrophic scars represent the grouping of Myo, which nodules can impede the correct movement of the surrounding tissues and be a source of pain [ 30 ].…”

Section: Reviewmentioning

confidence: 99%

“…By not respecting the needs of the skin (dermis and epidermis) when an undetermined intensity (pressure or stretching) is applied by the operator, inflammatory, pro-fibrotic phenomena, increased contracture, and further neurological disorders can be reproduced [ 10 , 13 , 16 , 22 , 23 , 31 , 34 , 36 , 43 , 45 - 47 ]. The elasticity of the skin does not depend on the manual approach, but on the processes that arise from the evolution of a lesion towards scar tissue; the skin will always retain an altered mechanical behavior, compared to the uninjured skin [ 14 , 22 , 23 , 30 , 37 , 43 ].…”

Section: Reviewmentioning

confidence: 99%

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Osteopathic Approach for Keloids and Hypertrophic Scars

Bordoni,

Escher,

Girgenti

et al. 2023

Cureus

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The skin is a complex organ, a system that influences and is influenced by the body system, with different skin layers always mechano-biologically active. In the presence of a lesion that damages the dermis, the skin undergoes sensory, morphological, and functional alterations. The subsequent adaptation is the formation of scar tissue, following distinct and overlapping biological phases. For reasons not yet fully elucidated, some healing processes lead to pathological scars, from which symptoms such as pain, itching, and functional limitations are derived. Currently, there is no gold standard treatment that fully meets the needs of different scars and can eliminate any symptoms that the patient suffers. One such treatment is manual medicine, which involves direct manual approaches to the site of injury. Reviewing the phases that allow the skin to be remodeled following an injury, this article reflects on the usefulness of resorting to these procedures, highlighting erroneous concepts on which the manual approach is based, compared to what the current literature highlights the cicatricial processes. Considering pathological scar adaptations, it would be better to follow a gentle manual approach.

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Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

Osteopathic Approach for Keloids and Hypertrophic Scars

Bordoni,

Escher,

Girgenti

et al. 2023

Cureus

View full text Add to dashboard Cite

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Advances in the Application of Noninvasive Skin Imaging Techniques in Acne Scars

Ning,

Jiang,

et al. 2024

Am J Clin Dermatol

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Towards next-generation diagnostic pathology: AI-empowered label-free multiphoton microscopy

Wang,

Pan,

Zhang

et al. 2024

Light Sci Appl

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Diagnostic pathology, historically dependent on visual scrutiny by experts, is essential for disease detection. Advances in digital pathology and developments in computer vision technology have led to the application of artificial intelligence (AI) in this field. Despite these advancements, the variability in pathologists’ subjective interpretations of diagnostic criteria can lead to inconsistent outcomes. To meet the need for precision in cancer therapies, there is an increasing demand for accurate pathological diagnoses. Consequently, traditional diagnostic pathology is evolving towards “next-generation diagnostic pathology”, prioritizing on the development of a multi-dimensional, intelligent diagnostic approach. Using nonlinear optical effects arising from the interaction of light with biological tissues, multiphoton microscopy (MPM) enables high-resolution label-free imaging of multiple intrinsic components across various human pathological tissues. AI-empowered MPM further improves the accuracy and efficiency of diagnosis, holding promise for providing auxiliary pathology diagnostic methods based on multiphoton diagnostic criteria. In this review, we systematically outline the applications of MPM in pathological diagnosis across various human diseases, and summarize common multiphoton diagnostic features. Moreover, we examine the significant role of AI in enhancing multiphoton pathological diagnosis, including aspects such as image preprocessing, refined differential diagnosis, and the prognostication of outcomes. We also discuss the challenges and perspectives faced by the integration of MPM and AI, encompassing equipment, datasets, analytical models, and integration into the existing clinical pathways. Finally, the review explores the synergy between AI and label-free MPM to forge novel diagnostic frameworks, aiming to accelerate the adoption and implementation of intelligent multiphoton pathology systems in clinical settings.

show abstract

Mapping the 3D remodeling of the extracellular matrix in human hypertrophic scar by multi-parametric multiphoton imaging using endogenous contrast

Cited by 3 publications

References 80 publications

Osteopathic Approach for Keloids and Hypertrophic Scars

Osteopathic Approach for Keloids and Hypertrophic Scars

Advances in the Application of Noninvasive Skin Imaging Techniques in Acne Scars

Towards next-generation diagnostic pathology: AI-empowered label-free multiphoton microscopy

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