Abstract:Insulin has been the cornerstone of diabetes treatment since its discovery over a century ago. Despite this, several aspects of insulin engagement with its target and off-target receptors remain unknown, thus limiting the use of structure-guided design of novel analogs. A recent spurt in structural information for the insulin and insulin-like growth factor 1 receptors (IR and IGF-1R), were leveraged in this study to gain a deeper, molecular-level understanding of ligand recognition at these targets. Molecular … Show more
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