Mapping quantitative trait loci for osteochondrosis in fetlock and hock joints and palmar/plantar osseus fragments in fetlock joints of South German Coldblood horses

Wittwer, Catherine; Löhring, Kathrin; Drögemüller, Cord; Hamann, H.; Rosenberger, E.; Distl, O.

doi:10.1111/j.1365-2052.2007.01610.x

Cited by 29 publications

(32 citation statements)

References 30 publications

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“…Various whole-genome scans using microsatellite markers revealed QTL in Hanoverian warmblood breeds and South German coldbloods (Dierks et al, 2007;Wittwer et al, 2007Wittwer et al, , 2008Wittwer et al, , 2009. Those studies only shared 1 QTL on Equus caballus (ECA) 16.…”

Section: Introductionmentioning

confidence: 98%

Genome-wide association studies for osteochondrosis in French Trotter horses1

Teyssèdre¹,

Dupuis

Guérin³

et al. 2012

Journal of Animal Science

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A genome-wide association study for osteochondrosis (OC) in French Trotter horses was carried out to detect QTL using genotype data from the Illumina EquineSNP50 BeadChip assay. Analysis data came from 161 sire families of French Trotter horses with 525 progeny and family sizes ranging from 1 to 20. Genotypes were available for progeny (n = 525) and sires with at least 2 progeny (n = 98). Radiographic data were obtained from progeny using at least 10 views to reveal OC. All radiographic findings were described by at least 2 veterinary experts in equine orthopedics, and severity indices (scores) were assigned based on the size and location of the lesion. Traits used were a global score, the sum of all severity scores lesions (GM, quantitative measurement), and the presence or absence of OC on the fetlock (FM), hock (HM), and other sites (other). Data were analyzed using 2 mixed models including fixed effects, polygenic effects, and SNP or haplotype cluster effects. By combining results with both methods at moderate evidence of association threshold P < 5 × 10(-5), this genome-wide association study displayed 1 region for GM on the Equus caballus chromosome (ECA) 13, 2 for HM on ECA 3 and 14, and 1 for other on ECA 15. One region on ECA 3 for HM represented the most significant hit (P = 3 × 10(-6)). By comparing QTL between traits at a decreased threshold (P < 5 × 10(-4)), the 4 QTL detected for GM were associated to a QTL detected for FM or HM but never both. Another interesting result was that no QTL were found in common between HM and FM.

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Section: Introductionmentioning

confidence: 98%

Genome-wide association studies for osteochondrosis in French Trotter horses1

Teyssèdre¹,

Dupuis

Guérin³

et al. 2012

Journal of Animal Science

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“…Early studies using primarily linkage based analyses (dependent on family data), to detect regions of the genome associated with OC in the horse have identified several putative quantitative trait loci (QTL) (Dierks et al 2007;Wittwer et al 2007b). As is typical for QTL 6 discovered using this approach, their effects are generally large but their locations are imprecise.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies to date have considered further subdivision of OC cases by joint affected, resulting in different QTL being identified for each subgroup (Dierks et al 2007;Wittwer et al 2007b). This is appealing given the apparent low correlation 22 among the occurrence of lesions of OC in different body locations (Jorgensen and Andersen 2000;Jorgensen et al 1995;van Grevenhof et al 2009b) and the corresponding idea that OC is in fact a localised disease (Ytrehus et al 2007).…”

mentioning

confidence: 99%

A genome-wide association study of osteochondritis dissecans in the Thoroughbred

et al. 2011

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“…Quantitative trait loci relating to osteochondrosis in South German Coldblood horses have been identified and implicate genes for collagen type-III, type-V and type-XXVII, as well as interleukin 6 (among others) as heritable components (Wittwer, Lohring, Drogemuller, Hamann, Rosenberger and Distl 2007).…”

Section: 8 7 Genetic Factorsmentioning

confidence: 99%

Calcified tissue structure in the distal condyle of the third metacarpal bone in young Thoroughbred horses

Doube¹

2017

Preprint

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Aims: To determine improvements in third metacarpal (Mc3) condylar microanatomy attributable to preconditioning exercise. To investigate developmental causes of Mc3 condylar fracture.Methods: Twelve Thoroughbred horses were raised at pasture; six received preconditioning exercise from 10 days. Calcein labels were administered 19 and 11 days prior to euthanasia at 18 months. Six horses also received 2 seasons of race-training and were euthanised at 3 years. Slices were taken from the distal Mc3 condyle in the frontal and dorsal-and palmar-oblique frontal planes, scanned with DXA and macerated (frontal slices) or embedded in PMMA (oblique slices).Articular calcified cartilage (ACC) and subchondral bone (SCB) in oblique slices were imaged using confocal scanning light microscopy and quantitative backscattered electron scanning electron microscopy. ACC and SCB in the palmar slice lateral parasagittal grooves were imaged using µCT and nanoindentation tested. Results: Characteristic spatial variations in ACC and SCB histomorphometric parameters were present, none of which was significantly related to preconditioning exercise. Thickened, aberrantly mineralised ACC was found in 13/24 parasagittal grooves in the palmar slices and on the sagittal ridge of 4/12 dorsal slices of 18-month-old horses. Deep to thickened ACC, SCB had an open marrow structure, having not adopted the buttress morphology of the normal SCB plate. SCB in 3-year-old horses had incorporated early ACC defects as notches in parasagittal grooves and a hyaline cartilage island in a sagittal ridge. ACC was less stiff and SCB more stiff in affected than unaffected parasagittal grooves. Chondroclastic resorption in the parasagittal groove may be retarded as early as 3-6 months, possibly due to localised inhibition of Dr Naomi Boxall has guided me through the PhD experience; as one of the several PhD students 5 Attribution I knew while an undergraduate at Massey University she gave me insight into coping with the varied challenges that postgraduate study entails. Naomi also helped correct my sometimes dubious spelling, grammar and punctuation while preparing documents for submission. Jen Swindlehurst provided a number of images of equine metacarpals from her own studies that I was kindly allowed to use in my presentations. Jen's work also (conveniently) supported my own, and it was nice to have a colleague who was so intimately familiar with the problem of condylar fracture. Several of Professor

show abstract

Mapping quantitative trait loci for osteochondrosis in fetlock and hock joints and palmar/plantar osseus fragments in fetlock joints of South German Coldblood horses

Cited by 29 publications

References 30 publications

Genome-wide association studies for osteochondrosis in French Trotter horses1

Genome-wide association studies for osteochondrosis in French Trotter horses1

A genome-wide association study of osteochondritis dissecans in the Thoroughbred

Calcified tissue structure in the distal condyle of the third metacarpal bone in young Thoroughbred horses

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