“…Creating large and permanent porosity in metal-organic frameworks (MOFs) is a prerequisite for particular applications, such as catalysis [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ], drug delivery [ 8 , 9 , 10 , 11 , 12 , 13 ], as well as the study of fundamental host-guest phenomena, including enzyme [ 14 , 15 , 16 , 17 ], protein [ 18 ], water [ 19 , 20 , 21 , 22 ], and nanoparticle [ 23 , 24 , 25 , 26 , 27 , 28 , 29 ] encapsulation. However, during the formation of MOFs with targeted porosity, there exists a trade-off between the pore size and framework stability, viz., the shorter ligands generally support stable MOFs with limited porosity, while the longer ligands prefer porous frameworks with limited scaffold stability [ 30 ].…”