Mapping of Optical Pathlength of Human Adult Head at Multi-Wavelengths in Near Infrared Spectroscopy

Katagiri, Ayano; Dan, Ippeita; Tuzuki, Daisuke; Okamoto, Masayuki; Yokose, Noriaki; Igarashi, Kouji; Hoshino, Tatsuya; Fujiwara, Tokuo; Katayama, Youichi; Yamaguchi, Yoshiki; Sakatani, Kaoru

doi:10.1007/978-1-4419-1241-1_29

Cited by 42 publications

(20 citation statements)

References 16 publications

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“…On the basis of these findings, the maximal values of total Hb changes in the left and right auditory channels were subjected to a two-way analysis of variance (ANOVA), with conditions (phoneme and prosody) and sides (left and right) as within-subject factors in each group. It should be noted that Katagiri et al’s (2010) findings do not extend to a comparison across different subjects. Moreover, the two different NIRS systems that differ in the number of lasers used for calculating Hb concentrations (2 vs. 3) were used for the school-age children (ETG-100 for school-age children who stutter and OMM-2001 for school-age children who do not stutter).…”

Section: Methodsmentioning

confidence: 76%

“…Consequently, the comparison or integration of data between different channels or across subjects may be difficult to justify. However, a recent study demonstrated that the optical path-lengths are similar among nearby channels and between homologous regions of left and right hemispheres within a subject (Katagiri et al, 2010). On the basis of these findings, the maximal values of total Hb changes in the left and right auditory channels were subjected to a two-way analysis of variance (ANOVA), with conditions (phoneme and prosody) and sides (left and right) as within-subject factors in each group.…”

Section: Methodsmentioning

confidence: 99%

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Functional Lateralization of Speech Processing in Adults and Children Who Stutter

et al. 2011

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Developmental stuttering is a speech disorder in fluency characterized by repetitions, prolongations, and silent blocks, especially in the initial parts of utterances. Although their symptoms are motor related, people who stutter show abnormal patterns of cerebral hemispheric dominance in both anterior and posterior language areas. It is unknown whether the abnormal functional lateralization in the posterior language area starts during childhood or emerges as a consequence of many years of stuttering. In order to address this issue, we measured the lateralization of hemodynamic responses in the auditory cortex during auditory speech processing in adults and children who stutter, including preschoolers, with near-infrared spectroscopy. We used the analysis–resynthesis technique to prepare two types of stimuli: (i) a phonemic contrast embedded in Japanese spoken words (/itta/ vs. /itte/) and (ii) a prosodic contrast (/itta/ vs. /itta?/). In the baseline blocks, only /itta/ tokens were presented. In phonemic contrast blocks, /itta/ and /itte/ tokens were presented pseudo-randomly, and /itta/ and /itta?/ tokens in prosodic contrast blocks. In adults and children who do not stutter, there was a clear left-hemispheric advantage for the phonemic contrast compared to the prosodic contrast. Adults and children who stutter, however, showed no significant difference between the two stimulus conditions. A subject-by-subject analysis revealed that not a single subject who stutters showed a left advantage in the phonemic contrast over the prosodic contrast condition. These results indicate that the functional lateralization for auditory speech processing is in disarray among those who stutter, even at preschool age. These results shed light on the neural pathophysiology of developmental stuttering.

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Section: Methodsmentioning

confidence: 76%

Section: Methodsmentioning

confidence: 99%

Functional Lateralization of Speech Processing in Adults and Children Who Stutter

et al. 2011

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“…Note that Hb signals analyzed in the current study do not directly represent cortical Hb concentration changes, but contain an unknown optical path length that cannot be measured. Direct comparison of Hb signals among different channels and regions should be avoided as optical path length is known to vary among cortical regions (Katagiri et al, 2010). Hence, we performed statistical analyses in a channel-wise manner.…”

Section: Methodsmentioning

confidence: 99%

Acute neuropharmacological effects of atomoxetine on inhibitory control in ADHD children: A fNIRS study

Nagashima¹,

Monden²,

Dan

et al. 2014

NeuroImage: Clinical

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The object of the current study is to explore the neural substrate for effects of atomoxetine (ATX) on inhibitory control in school-aged children with attention deficit hyperactivity disorder (ADHD) using functional near-infrared spectroscopy (fNIRS). We monitored the oxy-hemoglobin signal changes of sixteen ADHD children (6–14 years old) performing a go/no-go task before and 1.5 h after ATX or placebo administration, in a randomized, double-blind, placebo-controlled, crossover design. Sixteen age- and gender-matched normal controls without ATX administration were also monitored. In the control subjects, the go/no-go task recruited the right inferior and middle prefrontal gyri (IFG/MFG), and this activation was absent in pre-medicated ADHD children. The reduction of right IFG/MFG activation was acutely normalized after ATX administration but not placebo administration in ADHD children. These results are reminiscent of the neuropharmacological effects of methylphenidate to up-regulate reduced right IFG/MFG function in ADHD children during inhibitory tasks. As with methylphenidate, activation in the IFG/MFG could serve as an objective neuro-functional biomarker to indicate the effects of ATX on inhibitory control in ADHD children. This promising technique will enhance early clinical diagnosis and treatment of ADHD in children, especially in those with a hyperactivity/impulsivity phenotype.

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“…Hb signals analyzed in the current study do not directly represent cortical Hb concentration changes, but contain an unknown optical path length that cannot be measured. Since optical path length is known to vary among cortical regions, 68 direct comparison of Hb signals among different channels and regions should be avoided. Therefore, we performed channel-wise statistical analyses.…”

Section: Analysis Of Nirs Datamentioning

confidence: 99%

Neuropharmacological effect of methylphenidate on attention network in children with attention deficit hyperactivity disorder during oddball paradigms as assessed using functional near-infrared spectroscopy

et al. 2014

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Abstract. The current study aimed to explore the neural substrate for methylphenidate effects on attentional control in school-aged children with attention deficit hyperactivity disorder (ADHD) using functional near-infrared spectroscopy (fNIRS), which can be applied to young children with ADHD more easily than conventional neuroimaging modalities. Using fNIRS, we monitored the oxy-hemoglobin signal changes of 22 ADHD children (6 to 14 years old) performing an oddball task before and 1.5 h after methylphenidate or placebo administration, in a randomized, double-blind, placebo-controlled, crossover design. Twenty-two age-and gender-matched normal controls without methylphenidate administration were also monitored. In the control subjects, the oddball task recruited the right prefrontal and inferior parietal cortices, and this activation was absent in premedicated ADHD children. The reduced right prefrontal activation was normalized after methylphenidate but not placebo administration in ADHD children. These results are consistent with the neuropharmacological effects of methylphenidate to upregulate the dopamine system in the prefrontal cortex innervating from the ventral tegmentum (mesocortical pathway), but not the noradrenergic system from the parietal cortex to the locus coeruleus. Thus, right prefrontal activation would serve as an objective neurofunctional biomarker to indicate the effectiveness of methylphenidate on ADHD children in attentional control. fNIRS monitoring enhances early clinical diagnosis and the treatment of ADHD children, especially those with an inattention phenotype. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Mapping of Optical Pathlength of Human Adult Head at Multi-Wavelengths in Near Infrared Spectroscopy

Cited by 42 publications

References 16 publications

Functional Lateralization of Speech Processing in Adults and Children Who Stutter

Functional Lateralization of Speech Processing in Adults and Children Who Stutter

Acute neuropharmacological effects of atomoxetine on inhibitory control in ADHD children: A fNIRS study

Neuropharmacological effect of methylphenidate on attention network in children with attention deficit hyperactivity disorder during oddball paradigms as assessed using functional near-infrared spectroscopy

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