Mapping of MeLiM melanoma combining ICP-MS and MALDI-MSI methods

Vaníčková, Lucie; Do, Tomáš; Vejvodová, Markéta; Horák, Vratislav; Hubálek, Martin; Emri, Gabriella; Zemánková, Kristýna; Pavelicová, Kristýna; Křížková, Soňa; Faltusová, Veronika; Pompeiano, Antonio; Vaculovičová, Markéta; Zítka, Ondřej; Vaculovič, Tomáš; Adam, Vojtěch

doi:10.1016/j.ijbiomac.2022.01.139

Cited by 4 publications

(2 citation statements)

References 67 publications

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“…Some studies have shown that certain cell markers (CD protein) and integrins (integrin) on the cell membrane (nanoparticle membrane) are unique to melanoma cancer cells. 24 Therefore, this experiment showed the specificity of nanoparticle drug delivery. The qRT-PCR and Western blotting results indicate an upregulation trend in the expression of apoptosis-related genes when melanoma cells are co-cultured with ANPs.…”

Section: Discussionmentioning

confidence: 77%

Pioneering Astaxanthin-Tumor Cell Membrane Nanoparticles for Innovative Targeted Drug Delivery on Melanoma

Chang,

Wang,

Yang

et al. 2024

IJN

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Background Recently, the use of the tumor or its secretions as drug carriers has gradually become popular, with the advantages of high biocompatibility and enhanced drug delivery to specific cells. Melanoma is the most malignant tumor of all skin cancers; it is the most metastatic and, therefore, the most difficult to treat. The main purpose of this study is to develop nanovesicles with tumor cell membrane secretion properties to encapsulate target substances to enhance the therapeutic effect of cancer. Methods Astaxanthin was selected as an anticancer drug due to our previous research finding that astaxanthin has extremely high antioxidant, anti-ultraviolet damage, and anti-tumor properties. The manufacturing method of the astaxanthin nanovesicle carrier is to mix melanoma cells and astaxanthin in an appropriate ratio and then remove the genetic material and inflammatory factors of cancer cells by extrusion. Results In terms of results, after the co-culture of astaxanthin nanovesicles and melanoma cancer cells, it was confirmed that the ability of astaxanthin nanovesicles to inhibit the growth and metastasis of melanoma cancer cells was significantly better than the same amount of astaxanthin alone, and it had no effect on normal Human cells are also effective. There was no apparent harm on normal cells, indicating the ability of the vesicles to be selectively transported. Conclusion Our findings illustrated the potential of astaxanthin nanovesicles as an anticancer drug.

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Section: Discussionmentioning

confidence: 77%

Pioneering Astaxanthin-Tumor Cell Membrane Nanoparticles for Innovative Targeted Drug Delivery on Melanoma

Chang,

Wang,

Yang

et al. 2024

IJN

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“…Heavy metals are considered metallic elements (in some cases they comprise metalloids, such as arsenic) whose compounds can induce toxicity at a low level of exposure, thus posing a critical threat to human health [ 1 , 2 , 3 , 4 , 5 ]. Although they are naturally occurring, human and wildlife exposure to heavy metals has increased due to excessive anthropogenic activities that contribute significantly to environmental contamination (e.g., industrial production, mining, and smelting) [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Prospects of Biogenic Xanthan and Gellan in Removal of Heavy Metals from Contaminated Waters

et al. 2022

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Biosorption is considered an effective technique for the treatment of heavy-metal-bearing wastewaters. In recent years, various biogenic products, including native and functionalized biopolymers, have been successfully employed in technologies aiming for the environmentally sustainable immobilization and removal of heavy metals at contaminated sites, including two commercially available heteropolysaccharides—xanthan and gellan. As biodegradable and non-toxic fermentation products, xanthan and gellan have been successfully tested in various remediation techniques. Here, to highlight their prospects as green adsorbents for water decontamination, we have reviewed their biosynthesis machinery and chemical properties that are linked to their sorptive interactions, as well as their actual performance in the remediation of heavy metal contaminated waters. Their sorptive performance in native and modified forms is promising; thus, both xanthan and gellan are emerging as new green-based materials for the cost-effective and efficient remediation of heavy metal-contaminated waters.

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Imaging the elemental distribution within human malignant melanomas using Laser-Induced Breakdown Spectroscopy

Kopřivová,

Kiss,

Krbal

et al. 2024

Analytica Chimica Acta

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Mapping of MeLiM melanoma combining ICP-MS and MALDI-MSI methods

Cited by 4 publications

References 67 publications

Pioneering Astaxanthin-Tumor Cell Membrane Nanoparticles for Innovative Targeted Drug Delivery on Melanoma

Pioneering Astaxanthin-Tumor Cell Membrane Nanoparticles for Innovative Targeted Drug Delivery on Melanoma

Prospects of Biogenic Xanthan and Gellan in Removal of Heavy Metals from Contaminated Waters

Imaging the elemental distribution within human malignant melanomas using Laser-Induced Breakdown Spectroscopy

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