1988
DOI: 10.1016/0304-3940(88)90264-9
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Mapping of estrogen receptor-producing cells in the rat brain by in situ hybridization

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Cited by 85 publications
(34 citation statements)
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“…8B) 3) Discussion The in situ hybridization findings reported here demonstrated selective distribution of ERmRNA in the central hypothalamus, amygdala and uterus. The sites of ERmRNA-containing neurons were largely in agreement with those of ER in the previous autoradiographical (40) and immunohistochemical (48) studies, and with the in situ hybridization ones (42,43,50). Discrepancy exists, however, on the existence of ERmRNA in the amygdala between ours and Pelletier's (42).…”
Section: ) Ermrna Analysis In Uterine Endometrial Cancerssupporting
confidence: 58%
See 1 more Smart Citation
“…8B) 3) Discussion The in situ hybridization findings reported here demonstrated selective distribution of ERmRNA in the central hypothalamus, amygdala and uterus. The sites of ERmRNA-containing neurons were largely in agreement with those of ER in the previous autoradiographical (40) and immunohistochemical (48) studies, and with the in situ hybridization ones (42,43,50). Discrepancy exists, however, on the existence of ERmRNA in the amygdala between ours and Pelletier's (42).…”
Section: ) Ermrna Analysis In Uterine Endometrial Cancerssupporting
confidence: 58%
“…Our preliminary results have revealed the existence of ERmRNA even in poorly differentiated cancers in which ERs are absent, implying different regulation of the ER level in the cancer lacking in hormone dependency. Several in situ hybridization studies have reported the distribution of ERmRNA containing neurons in the rat brain (42,43,50), which is roughly similar as that of ER (40,48).…”
Section: ) Ermrna Analysis In Uterine Endometrial Cancersmentioning
confidence: 84%
“…Estrogen receptors are widely distributed in the brain, including the limbic system and the hypothalamus (48). Our findings implicate the CRH gene and, therefore, the HPA axis, as a potentially important target of ovarian steroids and a potential mediator of gender related differences in the stress response and HPA axis activity.…”
Section: Resultsmentioning
confidence: 81%
“…What is the mechanism by which a previously unresponsive neuronal type becomes responsive? Although estrogens can act to alter gene transcription (McEwen et al, 1978), it is unlikely that this is the case in the present study because in the hippocampus, both ␣-and ␤-estrogen receptors have been identified on interneurons and glial cells and not on dentate granule cells (Rainbow et al, 1982;L oy et al, 1988;Pelletier et al, 1988;Weiland et al, 1996;Kuiper et al, 1997;Li et al, 1997). Estradiol might act directly on membranes, altering their properties to induce glutamate release, thus increasing intraneuronal calcium, stimulating NMDA receptors, leading to the addition of dendritic spines (Parpura et al, 1994;Woolley and McEwen, 1994;K lintsova et al, 1995).…”
Section: Discussionmentioning
confidence: 94%