Abstract:Intrinsically disordered proteins (IDPs) that undergo a coupled folding and binding event are found to be important in many recognition and signaling processes. However, exactly how this mechanism is linked to these functions is not completely understood. This is primarily because the structural flexibility of IDPs limits the number of suitable characterization techniques. We are using small-angle neutron scattering (SANS) to investigate the structure and binding interaction properties between NCBD, an IDP reg… Show more
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