Mapping Motor Inhibition: Conjunctive Brain Activations across Different Versions of Go/No-Go and Stop Tasks

Rubia, Katya; Russell, Tamara; Overmeyer, S; Brammer, Michael; Bullmore, Edward T.; Sharma, Tonmoy; Simmons, Andrew; Williams, Steven; Giampietro, Vincent; Andrew, Chris; Taylor, Eric

doi:10.1006/nimg.2000.0685

Cited by 869 publications

(722 citation statements)

References 79 publications

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“…Bilateral inferior frontal gyrus (BA 44/45) and middle frontal gyrus (BA 9/46), ventromedial prefrontal cortex (BA 10/11), and anterior cingulate (BA 32) showed error-rate-related activation changes. These areas have been implicated in spatial attentional processes (Mesulam, 1999), conflict and error monitoring (Carter et al, 2000;Botvinick et al, 1999), inhibitory processes (Menon et al, 2001;Liddle et al, 2001;Rubia et al, 2001b), and control of eye movements (Luna et al, 1998). Thus, both groups allocate similar error-rate-related processing resources during this decision-making task.…”

Section: Decision-making and Errors In Schizophreniamentioning

confidence: 98%

“…Specifically, attentional processes that involve sustained, and possibly selective, attention (Coull et al, 1996), switching from task-relevant local to global targets (Fink et al, 1996;Lamb et al, 1989), voluntary attentional control (Hopfinger et al, 2000), and the distinction between taskirrelevant and task-relevant events (Downar et al, 2001;Kiehl et al, 2001;McCarthy et al, 1997) support the view that this area is critical for the extraction and selection of task-relevant information. Moreover, this area has been implicated in inhibitory control in a number of different paradigms (Garavan et al, 1999;Menon et al, 2001;Rubia et al, 2001b;Steel et al, 2001;Doricchi et al, 1997), that is, the allocation of resources to a response that has to compete with a highly overlearned and potentially habitual behavior. Several studies using decision-making paradigms have implicated the right posterior parietal cortex in autonomic arousal processes (Tranel and Damasio, 1994;Critchley et al, 2000), risk-taking decision-making (Ernst et al, 2002), and guessing (Elliott et al, 1999).…”

Section: Decision-making and Errors In Schizophreniamentioning

confidence: 99%

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Schizophrenia Subjects Show Intact Success-Related Neural Activation but Impaired Uncertainty Processing during Decision-Making

Paulus

Frank

Brown

et al. 2002

Neuropsychopharmacol

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Decision-making is a complex process that is important for everyday life. This study examined the effect of the degree of success, and outcome uncertainty, on decision-making and associated neural substrate activation in schizophrenia subjects (SZS) and normal comparison subjects (NCS). A total of 15 subjects with a diagnosis of schizophrenia and 15 age-and education-matched NCS participated in this study. These subjects completed the two-choice prediction task during functional magnetic resonance imaging. Decision-making characteristics and activation of neural substrates were obtained at 20, 50, or 80% error rate. Success and uncertainty influenced the behavioral characteristics on the two-choice prediction task, and the task-related activation in SZS and NCS. Neither success nor uncertainty differentially affected the behavioral characteristics of SZS relative to NCS during the two-choice prediction task. Nonetheless, there was a significant interaction between group and error rate in bilateral parietal cortex. The activation in NCS was the highest when the outcome was most uncertain. In contrast, task-related activation in SZS was not modulated by the degree of uncertainty. Thus, SZS failed to utilize the parietal cortex to process decision-making situations with highly uncertain outcomes.

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Section: Decision-making and Errors In Schizophreniamentioning

confidence: 98%

Section: Decision-making and Errors In Schizophreniamentioning

confidence: 99%

Schizophrenia Subjects Show Intact Success-Related Neural Activation but Impaired Uncertainty Processing during Decision-Making

Paulus

Frank

Brown

et al. 2002

Neuropsychopharmacol

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show abstract

“…The go/no-go task measures response inhibition, and is associated with activation of medial prefrontal, dorsolateral prefrontal, and parietal areas [111]. Response activation is diminished in PTSD and other anxiety disorders, and increased activation predicts response to treatment [112].…”

Section: Evidence From Neuroimaging Studiesmentioning

confidence: 99%

Cannabidiol as a Potential Treatment for Anxiety Disorders

et al. 2015

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Cannabidiol (CBD), a Cannabis sativa constituent, is a pharmacologically broad-spectrum drug that in recent years has drawn increasing interest as a treatment for a range of neuropsychiatric disorders. The purpose of the current review is to determine CBD's potential as a treatment for anxiety-related disorders, by assessing evidence from preclinical, human experimental, clinical, and epidemiological studies. We found that existing preclinical evidence strongly supports CBD as a treatment for generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive-compulsive disorder, and post-traumatic stress disorder when administered acutely; however, few studies have investigated chronic CBD dosing. Likewise, evidence from human studies supports an anxiolytic role of CBD, but is currently limited to acute dosing, also with few studies in clinical populations. Overall, current evidence indicates CBD has considerable potential as a treatment for multiple anxiety disorders, with need for further study of chronic and therapeutic effects in relevant clinical populations.

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“…In healthy control subjects, functional magnetic resonance imaging (fMRI) studies of response inhibition consistently demonstrate the underlying neurobiology to involve activation of the frontalstriatal circuit (Rubia et al, 2001;Aron et al, 2004;Simmonds et al, 2008). The prefrontal cortex (PFC), which includes the dorsolateral prefrontal cortex (DLPFC), orbital frontal cortex (OFC) and the inferior frontal cortex (IFC), plays a central role in executive functioning through its influence on subcortical and posterior cortical regions via extensive anatomical connections to these areas (Croxson et al, 2005;Leh et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Frontal lobe hypoactivation in medication-free adults with bipolar II depression during response inhibition

Penfold¹,

Vizueta²,

Townsend³

et al. 2015

Psychiatry Research: Neuroimaging

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Mapping Motor Inhibition: Conjunctive Brain Activations across Different Versions of Go/No-Go and Stop Tasks

Cited by 869 publications

References 79 publications

Schizophrenia Subjects Show Intact Success-Related Neural Activation but Impaired Uncertainty Processing during Decision-Making

Schizophrenia Subjects Show Intact Success-Related Neural Activation but Impaired Uncertainty Processing during Decision-Making

Cannabidiol as a Potential Treatment for Anxiety Disorders

Frontal lobe hypoactivation in medication-free adults with bipolar II depression during response inhibition

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