Mapping Molecular Orientation in Solids by Rotating-Frame NQR Techniques

Casanova, Federico; Robert, H; Pusiol, D. J.

doi:10.1006/jmre.1998.1448

Cited by 3 publications

(1 citation statement)

References 16 publications

(21 reference statements)

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“…Attempts at making images based on the NQR data, the so-called three-dimensional NQR or quadrupole resonance imaging (QRI), have been performed at a few laboratories including those of GS Harbisson (University of Nebraska at Lincoln, US), DJ Pusiol (National University of Córdoba, Argentina), R Kimmich (Ulm University, Germany) and BH Suits (Michigan Technological University, US). However, the results only permitted the presentation of the potential of NQR imaging, mainly for the spatial localization of strain or dynamics [59][60][61][62][63][64][65][66][67]. In application to pharmaceutical analysis, QRI not only permits the detection of the presence of all types of anomalies such as areas with a different degree of vitrification, oxidation or hydration or different polymorphous forms in the sample volume, but also provides information on their localization.…”

Section: Nuclear Quadrupole Resonance Spectroscopy Imagingmentioning

confidence: 97%

Applications of nuclear quadrupole resonance spectroscopy in drug development

Latosinńska¹

2007

Expert Opinion on Drug Discovery

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In this review, fundamentals of nuclear quadrupole resonance (NQR) spectroscopy are briefly outlined. Examples of its applications in drug development are discussed to demonstrate that the NQR method is a sophisticated, non-destructive and valuable analytical technique for studying pharmaceuticals, providing effective assistance at the two main steps of drug development: the physical and chemical characterization of the active pharmaceutical ingredients (API) at the analytical step and API development. This review covers different aspects of the use of NQR spectroscopy for drug development and analysis and illustrates the power and versatility of this method in the determination of impurities, polymorphic forms, the drug's structure and conformation, characterization of the interactions between the drug and ligands, search for analogs (second- or third-generation drugs) and the drug's thermal stability. Lastly, NQR advantages and restrictions in the aspect of application in drug development studies are summarized.

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Section: Nuclear Quadrupole Resonance Spectroscopy Imagingmentioning

confidence: 97%

Applications of nuclear quadrupole resonance spectroscopy in drug development

Latosinńska¹

2007

Expert Opinion on Drug Discovery

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NQR: From imaging to explosives and drugs detection

Osán

Cerioni

Forguez³

et al. 2007

Physica B: Condensed Matter

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Authentication of Medicines Using Nuclear Quadrupole Resonance Spectroscopy

Chen

Zhang

Barras

et al. 2016

IEEE/ACM Trans. Comput. Biol. and Bioinf.

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The production and sale of counterfeit and substandard pharmaceutical products, such as essential medicines, is an important global public health problem. We describe a chemometric passport-based approach to improve the security of the pharmaceutical supply chain. Our method is based on applying nuclear quadrupole resonance (NQR) spectroscopy to authenticate the contents of medicine packets. NQR is a non-invasive, non-destructive, and quantitative radio frequency (RF) spectroscopic technique. It is sensitive to subtle features of the solid-state chemical environment and thus generates unique chemical fingerprints that are intrinsically difficult to replicate. We describe several advanced NQR techniques, including two-dimensional measurements, polarization enhancement, and spin density imaging, that further improve the security of our authentication approach. We also present experimental results that confirm the specificity and sensitivity of NQR and its ability to detect counterfeit medicines.

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Mapping Molecular Orientation in Solids by Rotating-Frame NQR Techniques

Cited by 3 publications

References 16 publications

Applications of nuclear quadrupole resonance spectroscopy in drug development

Applications of nuclear quadrupole resonance spectroscopy in drug development

NQR: From imaging to explosives and drugs detection

Authentication of Medicines Using Nuclear Quadrupole Resonance Spectroscopy

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