Mapping memory function in the medial temporal lobe with the immediate-early gene Arc

Sauvage, Magdalena; Nakamura, N.; Beer, Zachery

doi:10.1016/j.bbr.2013.04.048

Cited by 40 publications

(41 citation statements)

References 156 publications

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“…Finally, taking into consideration methodological issues, it is important to mention that because performing in vivo electrophysiology recordings simultaneously in ten distant brain areas remains a major challenge and because using a lesion/inactivation/optogenetic approach was unlikely to yield the spatial resolution necessary to tease apart the specific function of each subarea/cell layer within subregions, a high‐resolution molecular imaging approach was favored to assess the involvement of the LEC, CA1, and CA3 in familiarity. This technique is based on the detection of the immediate‐early gene Arc , which is closely tied to synaptic plasticity and memory demands, and is commonly used as a marker of cell activation to map activity in the medial temporal lobe (Bramham et al, ; Guzowski et al, ; Kubik et al, ; Sauvage et al, ; Shepherd & Bear, ). In addition, Arc expression was reported to better reflect behavioral task demands than other IEGs, such as c‐fos and zif268 , and not stress levels or motor activity (Guzowski et al, , 2001; Nakamura et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…To do so, a molecular imaging approach with cellular resolution was used to image brain activity of rats performing a version of a standard human memory task adapted to rats that yields judgments based on familiarity (Guzowski, Setlow, Wagner, & McGaugh, 1999; Koen & Yonelinas, ; Sauvage et al, ). This technique is based on the detection of the immediate‐early gene Arc , closely tied to synaptic plasticity and memory demands (Bramham, Worley, Moore, & Guzowski, ; Guzowski, McNaughton, Barnes, & Worley, ; Guzowski et al, ; Kubik, Miyashita, & Guzowski, ; Sauvage, Nakamura, & Beer, ; Shepherd & Bear, ). Control groups without memory demands and/or relying on both recollection and familiarity were also generated and activity patterns assessed in the superficial and deep layers of LEC and in proximal, distal and ventral CA1 and CA3 compared across groups.…”

Section: Introductionmentioning

confidence: 99%

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Recognition memory: Cellular evidence of a massive contribution of the LEC to familiarity and a lack of involvement of the hippocampal subfields CA1 and CA3

et al. 2017

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A highly debated issue in memory research is whether familiarity is supported by the parahippocampal region, especially the lateral (LEC) and the perirhinal (PER) cortices, or whether it is supported by the same brain structure as recollection: the hippocampus. One reason for this is that conflicting results have emerged regarding the contribution of the hippocampus to familiarity. This might stem from the lack of dissociation between hippocampal subfields CA1 and CA3 as these areas are involved to a different extent in processes which are pertinent to familiarity. Another reason is that empirical evidence for a contribution of the LEC is still missing. Furthermore, it is unclear whether the superficial and the deep layers of the LEC would equally contribute to this process as these layers are differentially recruited during memory retrieval which partly relies on familiarity. To identify the specific contribution of the LEC, CA1, and CA3, we imaged with cellular resolution activity in the brain of rats performing a version of a standard human memory task adapted to rats that yields judgments based on familiarity. Using this translational approach, we report that in striking contrast to CA1 and CA3, the LEC is recruited for familiarity-judgments and that its contribution is comparable to that of the PER. These results show for the first time that the LEC, specifically its deep layers, contributes to familiarity and constitute the first cellular evidence that the hippocampus does not, thus establishing that familiarity does not share the same neural substrate as recollection.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recognition memory: Cellular evidence of a massive contribution of the LEC to familiarity and a lack of involvement of the hippocampal subfields CA1 and CA3

et al. 2017

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“…Functional differences along the proximodistal axis of CA1 related to spatial information content (Henriksen et al, 2010;Hartzell et al, 2013) support this notion. Functional differences along the CA3 transverse axis have also been reported (Sauvage et al, 2013).…”

Section: The Transverse Topography and Its Functional Implicationsmentioning

confidence: 92%

Hippocampal Formation

Cappaert

Strien

Witter

2015

The Rat Nervous System

118

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“…Because performing in vivo electrophysiology recording in specific cell layers is still a major challenge and using a lesion/inactivation approach was unlikely to yield the spatial resolution necessary to tease apart the involvement of the deep and the superficial layers of the LEC, a high-resolution molecular imaging technique (e.g., to the cellular level) was employed. This imaging technique is based on the detection of the expression of the immediate-early gene Arc which has been especially linked to plasticity processes and cognitive demands and has been recently used for mapping cognitive processes in the medial temporal lobe (Guzowski et al, 1999; Sauvage et al, 2013). …”

Section: Introductionmentioning

confidence: 99%

Regional Specific Evidence for Memory-Load Dependent Activity in the Dorsal Subiculum and the Lateral Entorhinal Cortex

Nakamura

Maingret

et al. 2017

Front. Syst. Neurosci.

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The subiculum and the lateral entorhinal cortex (LEC) are the main output areas of the hippocampus which contribute to spatial and non-spatial memory. The proximal part of the subiculum (bordering CA1) receives heavy projections from the perirhinal cortex and the distal part of CA1 (bordering the subiculum), both known for their ties to object recognition memory. However, the extent to which the proximal subiculum contributes to non-spatial memory is still unclear. Comparatively, the involvement of the LEC in non-spatial information processing is quite well known. However, very few studies have investigated its role within the frame of memory function. Thus, it is not known whether its contribution depends on memory load. In addition, the deep layers of the EC have been shown to be predictive of subsequent memory performance, but not its superficial layers. Hence, here we tested the extent to which the proximal part of the subiculum and the superficial and deep layers of the LEC contribute to non-spatial memory, and whether this contribution depends on the memory load of the task. To do so, we imaged brain activity at cellular resolution in these areas in rats performing a delayed nonmatch to sample task based on odors with two different memory loads (5 or 10 odors). This imaging technique is based on the detection of the RNA of the immediate-early gene Arc, which is especially tied to synaptic plasticity and behavioral demands, and is commonly used to map activity in the medial temporal lobe. We report for the first time that the proximal part of the subiculum is recruited in a memory-load dependent manner and the deep layers of the LEC engaged under high memory load conditions during the retrieval of non-spatial memory, thus shedding light on the specific networks contributing to non-spatial memory retrieval.

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Mapping memory function in the medial temporal lobe with the immediate-early gene Arc

Cited by 40 publications

References 156 publications

Recognition memory: Cellular evidence of a massive contribution of the LEC to familiarity and a lack of involvement of the hippocampal subfields CA1 and CA3

Recognition memory: Cellular evidence of a massive contribution of the LEC to familiarity and a lack of involvement of the hippocampal subfields CA1 and CA3

Hippocampal Formation

Regional Specific Evidence for Memory-Load Dependent Activity in the Dorsal Subiculum and the Lateral Entorhinal Cortex

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