Mapping local mechanical properties of human healthy and osteoporotic femoral heads

Buccino, Federica; Zagra, Luigi; Savadori, Paolo; Galluzzo, Alessandro; Colombo, Chiara; Grossi, Giacomo; Banfi, Giuseppe; Vergani, L.

doi:10.1016/j.mtla.2021.101229

Cited by 6 publications

(7 citation statements)

References 26 publications

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“…In contrast, fixed orthodontic appliances impose constant and more significant traction on the periodontal ligament, increasing the likelihood of inflammation and bleeding—factors contributing to the deterioration in oral and periodontal health indices. Although the literature is not unanimous in reaching a conclusion on this matter, it is logical to think that a reduction, even if only sporadic, in mechanical stress, may positively affect overall oral health [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Microbiological Analysis of Plaque and Its Composition in Three Patient Groups under Different Orthodontic Treatments

Cenzato,

Occhipinti,

D’amici

et al. 2024

Dentistry Journal

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Background: This article analyzes differences in microbiological parameters and periodontal health conditions among three patient groups: those undergoing conventional orthodontic treatment with fixed appliances, patients undergoing orthodontic treatment with clear aligners, and a control group receiving no treatment. Materials and Methods: In this study, 60 patients were enrolled. The microbiological analysis employed a qualitative and semi-quantitative methodology of bacterial morphotype analysis. Results: The analyses revealed a significant difference in favor of clear oral and periodontal health aligners. This could be attributed to better bacterial biofilm removal and reduced mechanical stress on the periodontal ligament, factors facilitated by the ease of clear aligner removal. Significant differences (p-value < 0.05) were observed for the Full-Mouth Plaque Score, Full-Mouth Bleeding Score, Plaque Index, and periodontal health assessment measurements. Conclusions: Although overall hygiene appears to be improved in patients in the aligners group compared to those treated with conventional orthodontic appliances, there are no statistically significant results regarding plaque composition. Microbiological aspects will be further addressed using more specific techniques in the follow-up of this research.

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Section: Discussionmentioning

confidence: 99%

Microbiological Analysis of Plaque and Its Composition in Three Patient Groups under Different Orthodontic Treatments

Cenzato,

Occhipinti,

D’amici

et al. 2024

Dentistry Journal

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“…Traditional evaluation of the sagittal discrepancy between the maxilla and the mandible have been generally performed on the bone structure without considering the soft-tissue profile [ 6 , 7 , 26 , 27 ]. Indeed, while the underling upper and lower jaws notify most of the facial shape, the real physiognomy of the considered patient is due also to soft tissues [ 28 , 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

The Maxilla-Mandibular Discrepancies through Soft-Tissue References: Reliability and Validation of the Anteroposterior Measurement

et al. 2023

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This research aimed to identify a new measurement to diagnose the sagittal maxillary and mandibular difference that considers the patient’s profile (soft tissue Wits appraisal: obtained by projecting points A and B on the occlusal plane and subsequently measuring the linear distance between the two points). This new measurement was compared to the conventional Wits appraisal obtained to diagnose sagittal jaw discrepancy. In total, 300 subjects (162 males, 138 females) aged between 6 and 50 years requiring orthodontic treatment were analyzed. The cephalometric tracings on the pre-treatment lateral cephalometric radiographs were obtained and the two measurements taken were the Wits appraisal and a new measurement which were both calculated and compared. The analysis of the linear correlations between the conventional Wits value and the measurement obtained on the soft-tissue were undertaken. The relevance was established at 5% (p < 0.05). The mean values were also calculated within sex and age classes, and comparisons between sexes were obtained employing the t test Student’s for independent samples. Subsequently, chi-square analysis was also utilized to verify the sex distributions in the age groups considered. The results obtained suggested that these two measurements were significantly correlated with each other, with no characteristic patterns of sex or age. These data allowed an estimation of the reference values of the new measurement (−1.9 mm and 5.4 mm for patients with Class I molar relationship) showing that the former was more variable than the latter. The new measurement could allow for an accurate evaluation of the jaws sagittal discrepancy from soft tissue analysis.

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“…Patient age, gender and clinical evaluation of each samples are summarized in Table 1. Samples are cut along the principal direction of the compressive and tensile lines [36]: The longitudinal z-axis of each sample coincides with the force lines direction. The cut segments are then fixed in formaldehyde to avoid bacteria contamination, stored in 70% ethanol and embedded into epoxy resin endcaps.…”

Section: Bone Specimen Preparationmentioning

confidence: 99%

“…Firstly, post-processing is performed in Matlab to obtain an stl. file of each sample [36]. Secondly, optimization of stl files is performed in 3-matic (Mimics, Materialize, Germany).…”

Section: Post-processing Of the Scanned Samplesmentioning

confidence: 99%

Effect of trabecular architectures on the mechanical response in osteoporotic and healthy human bone

Bregoli,

Biffi,

Tuissi

et al. 2024

Med Biol Eng Comput

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Research at the mesoscale bone trabeculae arrangement yields intriguing results that, due to their clinical resolution, can be applied in clinical field, contributing significantly to the diagnosis of bone-related diseases. While the literature offers quantitative morphometric parameters for a thorough characterization of the mesoscale bone network, there is a gap in understanding relationships among them, particularly in the context of various bone pathologies. This research aims to bridge these gaps by offering a quantitative evaluation of the interplay among morphometric parameters and mechanical response at mesoscale in osteoporotic and non-osteoporotic bones. Bone mechanical response, dependent on trabecular arrangement, is defined by apparent stiffness, computationally calculated using the Gibson-Ashby model. Key findings indicate that: (i) in addition to bone density, measured using X-ray absorptiometry, trabecular connectivity density, trabecular spacing and degree of anisotropy are crucial parameters for characterize osteoporosis state; (ii) apparent stiffness values exhibit strong correlations with bone density and connectivity density; (iii) connectivity density and degree of anisotropy result the best predictors of mechanical response. Despite the inherent heterogeneity in bone structure, suggesting the potential benefit of a larger sample size in the future, this approach presents a valuable method to enhance discrimination between osteoporotic and non-osteoporotic samples. Graphical Abstract

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Mapping local mechanical properties of human healthy and osteoporotic femoral heads

Cited by 6 publications

References 26 publications

Microbiological Analysis of Plaque and Its Composition in Three Patient Groups under Different Orthodontic Treatments

Microbiological Analysis of Plaque and Its Composition in Three Patient Groups under Different Orthodontic Treatments

The Maxilla-Mandibular Discrepancies through Soft-Tissue References: Reliability and Validation of the Anteroposterior Measurement

Effect of trabecular architectures on the mechanical response in osteoporotic and healthy human bone

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