Mapping levels of theory of mind in Alzheimer's disease: A preliminary study

Castelli, Ilaria; Pini, Alessandra; Alberoni, Margherita; Liverta-Sempio, Olga; Baglio, Francesca; Massaro, Davide; Marchetti, Antonio; Nemni, R.

doi:10.1080/13607863.2010.513038

Cited by 88 publications

(106 citation statements)

References 57 publications

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“…So, in the behavioral domain, the trend of an aging-related increasing impairment in mentalizing is further confirmed: typical elderly start to show an impairment in the complex ToM levels [50], which is found also in aMCI patients and proceeds further in AD patients, where several works reported a ToM deficit in second-order level of false belief reasoning [31,50,52,55,56]. At the behavioral level, in the RME performance we observed a worse result (although not statistically significant) of aMCI patients compared to CTRs, which is in line with the above mentioned result found in the paper-pencil ToM battery.…”

Section: Discussionmentioning

confidence: 55%

“…On the contrary, in unsuccessful neurocognitive aging, extensive literature has demonstrated the presence of ToM deficits at the behavioral level in various types of dementia: frontotemporal dementia [29][30][31][32][33][34][35][36][37], Parkinson's disease [38][39][40][41][42][43][44][45][46][47][48][49], and Alzheimer's disease (AD) [31,36,[50][51][52][53][54][55][56]. With regards to AD, several works reported a ToM deficit in second-order level of false belief reasoning [31,52,55,56] and only one found an impairment at basic levels [52].…”

Section: Introductionmentioning

confidence: 98%

“…With regards to AD, several works reported a ToM deficit in second-order level of false belief reasoning [31,52,55,56] and only one found an impairment at basic levels [52]. Castelli and colleagues [50] contributed to this topic with the discovery of a specific pattern of deterioration in ToM abilities in AD patients: the most complex levels of mentalizing are impaired, whereas the intermediate and simplest ones are preserved, thus following backward the developmental steps that are typical of the acquisition of ToM abilities. Moreover, in AD patients the impairment in executive functions and memory correlated with the impairment in the more complex mentalizing abilities.…”

Section: Introductionmentioning

confidence: 99%

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Theory of Mind in Amnestic Mild Cognitive Impairment: An fMRI Study

Baglio

Castelli

Alberoni

et al. 2012

JAD

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Theory of Mind (ToM) undergoes changes at the behavioral level in pathological aging (Alzheimer's disease (AD)) and at the neural level in physiological aging. The aim was to determine if there are changes in ToM in the behavioral and neural domains in old subjects with high risk of switching from successful to unsuccessful neurocognitive aging. Patients with amnestic mild cognitive impairment (aMCI) syndrome were studied, since aMCI was proposed to fill the gap between normal aging and dementia. Sixteen aMCI patients (mean age 71 years) and fifteen healthy controls (mean age 67 years) with no differences in age or education were subjected to increasingly complex ToM tasks and to fMRI scanning while performing the Reading the Mind in the Eyes test (RME), which attributes mental states by focusing on eye-gaze. aMCI subjects had worse performances in two second order false belief tasks, confirming the decay of ToM on the behavioral level. Despite a minor activation of some components (posterior end of the superior temporal sulcus and temporal pole) of the ToM neural circuit, no significant differences in the behavioral performances to the RME was found in aMCI compared to controls. Probably the preservation of the mirror neuron system (precentral gyrus-BA 6; Broca area - BA 44) and the stronger involvement of frontal areas (middle and medial frontal cortex and anterior cingulate cortex) supplemented the decay of part of the mentalizing neural circuit, preserving task performance.

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Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Theory of Mind in Amnestic Mild Cognitive Impairment: An fMRI Study

Baglio

Castelli

Alberoni

et al. 2012

JAD

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“…С одной стороны, исследо-вания показывают возрастное улучше-ние понимания человеком психического состояния другого [3], но вместе с тем отмечается наличие дефицита компо-нентов модели психического в пожилом и старческом возрасте [26].…”

Section: социальная психология и общество 2015 г том 6 №unclassified

Features of Social Cognition in Late Adulthood

Melehin

Sergienko

2015

Social Psychology and Society

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За последние несколько лет в иссле-состояния в разных областях изучения все довании модели психического (theory of больший интерес привлекает пожилой mind), способности понимать психические и старческий возраст. Так, в социальных Для цитаты: Мелёхин А.И, Сергиенко Е.А. Специфика социального познания в пожилом и старческом возрасте // Со-циальная психология и общество.

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“…There is a further reason why clinicians and researchers should look to pragmatic disorders for criteria that can be used in a differential diagnosis of the (Kao et al 2009;Nordlund et al 2010;Castelli et al 2011, Duval et al 2012. Pragmatic language skills are particularly sensitive to the ToM and executive function deficits that are found in the dementias.…”

Section: Beyond Schizophreniamentioning

confidence: 99%

Establishing Diganostic Criteria: The Role of Clinical Pragmatics

Cummings

2012

Lodz Papers in Pragmatics

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The study of pragmatic disorders is of interest to speech-language pathologists who have a professional responsibility to assess and treat communication impairments. However, these disorders, it will be argued in this paper, have a significance beyond the clinical management of clients with communication impairments. Specifically, pragmatic disorders can now make a contribution to the diagnosis of a range of clinical conditions in which communication is adversely affected. These conditions include attention deficit hyperactivity disorder (ADHD), the autistic spectrum disorders, schizophrenia and the dementias. Pragmatic disorders are already among the criteria used to diagnose some of these conditions (e.g. ADHD), although they are not described in these terms. In other conditions (e.g. the dementias), pragmatic disorders have potential diagnostic value in the absence of reliable biomarkers markers of these conditions and similar initial presenting symptoms. Using clinical data, and the findings of empirical studies, the case is made for the inclusion and/or greater integration of pragmatic disorders in the formal classificatory systems that are used to diagnose a range of disorders. A previously unrecognised role for pragmatic impairments in the nosology and diagnosis of clinical disorders is thereby established.

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Mapping levels of theory of mind in Alzheimer's disease: A preliminary study

Cited by 88 publications

References 57 publications

Theory of Mind in Amnestic Mild Cognitive Impairment: An fMRI Study

Theory of Mind in Amnestic Mild Cognitive Impairment: An fMRI Study

Features of Social Cognition in Late Adulthood

Establishing Diganostic Criteria: The Role of Clinical Pragmatics

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