Mapping language with resting‐state functional magnetic resonance imaging: A study on the functional profile of the language network

Assessment of impaired/preserved cortical regions in brain tumours is typically performed via intraoperative direct brain stimulation of eloquent areas or task-based functional MRI. One main limitation is that they overlook distal brain regions or networks that could be functionally impaired by the tumour. This study aims: 1) to investigate the impact of brain tumours on the cortical synchronization of brain networks measured with resting-state functional magnetic resonance imaging (resting-state networks) both near the lesion and remotely; 2) to test whether potential changes in resting state networks correlate with cognitive status. The sample included twenty-four glioma patients (mean age 58.1 ± 16.4y) with different pathological staging. We developed a new method for single subject localization of resting state networks abnormalities. First, we derived the spatial pattern of the main resting state networks by means of the group guided independent component analysis. This was informed by a high-resolution resting state networks template derived from an independent sample of healthy controls. Second, we developed a spatial similarity index to measure differences in network topography and strength between healthy controls and individual brain tumour patients. Next, we investigated the spatial relationship between altered networks and tumour location. Finally, multivariate analyses related cognitive scores across multiple cognitive domains (attention, language, memory, decision making) with patterns of multi-network abnormality. We found that brain gliomas cause broad alterations of resting state networks topography that occurred mainly in structurally normal regions outside the tumour and oedema region. Cortical regions near the tumour often showed normal synchronization. Finally, multi-network abnormalities predicted attention deficits. Overall, we present a novel method for the functional localization of resting state networks abnormalities in individual glioma patients. These abnormalities partially explain cognitive disabilities and shall be carefully navigated during surgery.

show abstract

“…Finally, for the LANG, we have referred to the spatial patterns reported by both task-based 49 and resting-state studies. 50 , 51 …”

Section: Methodsmentioning

confidence: 99%

Widespread cortical functional disconnection in gliomas: an individual network mapping approach

Silvestri

Moretto

Facchini

et al. 2022

Brain Communications

View full text Add to dashboard Cite

show abstract

“…Commonly activated regions in this study were the fusiform and lingual gyri (associated with the visual association), midcingulate and superior medial frontal gyri (asso-ciated with cognitive motor control, self-processing, and mentalizing), the inferior orbitofrontal gyrus (associated with cognitive reappraisal), and the inferior frontal cortex (associated with the mirror neuron system). The results of this study cannot suggest TAF-specific brain regions because most of these regions were overlapped with language and semantic networks [ 30 - 32 ]. However, the results of this study may contain several possible implica-tions.…”

Section: Discussionmentioning

confidence: 96%

The Neural Correlates of Positive Versus Negative Thought-action Fusion in Healthy Young Adults

Lee

Cha

Jang

et al. 2021

Clin Psychopharmacol Neurosci

View full text Add to dashboard Cite

Objective: Thought-action fusion (TAF), one of the most-studied dysfunctional beliefs in obsessive-compulsive disorder, represents an individual's belief that his/her thoughts directly influence events. TAF belief types are divided into personal thoughts relating to positive (positive TAF) and negative outcomes (negative TAF). However, the neural mechanisms underlying both aspects of the TAF response remain elusive. Methods: This functional magnetic resonance imaging study aimed to investigate the neural circuits related to positive and negative TAF and their relationships with psychological measures. Thirty-one healthy male volunteers participated in a modified TAF task wherein they were asked to read the name of a close person embedded in positive statements (PS) or negative statements (NS). Results: Conjunction analysis revealed activation of the fusiform and lingual gyri, midcingulate and superior medial frontal gyri, inferior orbitofrontal gyrus, and temporoparietal junction. The NS ＞ PS comparison showed additional activation in the precuneus and medial prefrontal cortex, superior frontal gyrus, insula, globus pallidus, thalamus, and midbrain. Precuneus activity was associated with the TAF score among these areas. Moreover, activity in the inferior orbitofrontal gyrus, insula, superior, middle and medial frontal gyri, globus pallidus, inferior parietal lobule, and precuneus was associated with dimensional obsessive-compulsive scores. In contrast, the PS ＞ NS comparison revealed no significant activation. Conclusion: These results suggest that negative TAF, relative to positive TAF, recruits additional regions for self-referential processing, salience, and habitual responding, which may contribute to the activation of the belief that a negative thought increases the probability of that negative outcome.

show abstract

“…While the existence of a dual -ventral and dorsal stream -connectional architecture constituting the core LN is well described [57], their function and connectivity remain controversial [58][59][60]. It is now recognised that the LN spatially overlaps with several other association networks [61], despite maintaining considerable functional selectivity for processing essential aspects of human language [62,63]. Thus, concurrent with the realization that multiple brain networks are crucial for our language behaviour [64], more anatomical precision has been emerging in defining the core LN and constituent parts [65].…”

Section: The Challenges Of Studying the Lnmentioning

confidence: 99%

Language Network Dysfunction and Formal Thought Disorder in schizophrenia

Palaniyappan¹,

Homan²,

Alonso-Sánchez³

2022

Preprint

View full text Add to dashboard Cite

BackgroundPathophysiological inquiries into schizophrenia require a consideration of one of its defining features: disorganisation and impoverishment in verbal behaviour. This feature, often captured using the term Formal Thought Disorder, still remains to be one of the most poorly understood and often understudied dimensions of schizophrenia. AimIn this review, we consider the various challenges that need to be addressed for us to move towards mapping FTD (construct) to a brain network level account (circuit). This construct-to-circuit mapping goal is now becoming more plausible than it ever was, given the advent of tools providing objective readouts of human speech. ConclusionsWe suggest that any comprehensive pathophysiological model of schizophrenia must satisfactorily account for the onset and persistence of FTD and address the nature of Language Network dysfunction in this illness. To this end, we consider the need for phenotype refinement, robust experimental designs, informed analytical choices and suggest specific steps that can be taken towards the deciphering the neural mechanisms underwriting FTD, and the translational promise of improved interpersonal communication and reduced social disability.

show abstract

Mapping language with resting‐state functional magnetic resonance imaging: A study on the functional profile of the language network

Cited by 33 publications

References 90 publications

Widespread cortical functional disconnection in gliomas: an individual network mapping approach

Widespread cortical functional disconnection in gliomas: an individual network mapping approach

The Neural Correlates of Positive Versus Negative Thought-action Fusion in Healthy Young Adults

Language Network Dysfunction and Formal Thought Disorder in schizophrenia

Contact Info

Product

Resources

About