Mapping Intellectual Structures and Research Hotspots of Triple Negative Breast Cancer: A Bibliometric Analysis

Hao, Kai-jun; Jia, Xiao; Dai, Wenting; Huo, Ze-min; Zhang, Huaqiang; Liu, Jingwei; Wang, Xiaobing

doi:10.3389/fonc.2021.689553

Cited by 21 publications

(14 citation statements)

References 78 publications

(93 reference statements)

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“…Prediction shows the presence of 1 functional domain with phospholipase D/nuclease at (94-288) aa of the protein. The nuclease superfamily has a common motif HxK (x)4D (x)6GSxN with signal transduction, lipid biosynthesis, pathogenic bacteria, and viral restriction nucleic acid endonucleases related to signaling that affect ejection and cell drink and receptors [ 46 ] and regulation of actin cytoskeletal reorganization. Intercellular membrane transport is controlled, while it itself is controlled by phosphatidylinositol 4,5-diphosphate, PKC ADP-related factor, and rho family GTPase tuning.…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics Method Was Used to Analyze the Highly Expressed Gene FAM83A of Breast Cancer in Young Women

Tang

Wang

et al. 2022

Applied Bionics and Biomechanics

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Objectives. Preliminary analysis of breast cancer related to unknown functional gene FAM83A through bioinformatics knowledge to inform further experimental studies. Select high expression genes for breast cancer and use bioinformatics methods to predict the biological function of FAM83A. Methods. Genes with significant differences in expression between breast tumors and normal breast tissue libraries were selected from CGAP’s SAGE Digital Gene Expression Displayer (DGED) database. An unknown functional gene, FAM83A, which is highly expressed in breast cancer, was screened. We performed an analysis of the gene structure, subcellular localization, physicochemical properties of the encoding products, functional sites, protein structure, and functional domains. Results. Through SAGE DGED, a total of 185 genes with expression differences were found. The structure and function of FAM83A have ideal predictions, and it is generally determined that this gene encodes a nuclear protein with a nucleoprotein. The active site of PLDc and the functional domain of DUF1669 can be involved in signal transduction and gene expression regulation in tumorigenesis and metastasis. Digital gene representation of the Tumor Genome Project Data Library was used to select differentially expressed genes in breast cancer tissue and breast benign tumor tissue. Conclusion. Studies show that FAM83A is a potential research target associated with tumorigenesis and metastasis. Initial tests confirmed the expression of this gene. Lay a solid foundation for further research learning. FAM83A is a highly expressed gene in breast cancer and can serve as a target for studying molecular mechanisms in breast cancer.

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Section: Discussionmentioning

confidence: 99%

Bioinformatics Method Was Used to Analyze the Highly Expressed Gene FAM83A of Breast Cancer in Young Women

Tang

Wang

et al. 2022

Applied Bionics and Biomechanics

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“…However, because CMD involves multiple disciplines and fields, gaining systematic and comprehensive knowledge about the current state of research is difficult. Bibliometrics is a discipline that combines mathematics and statistics to evaluate research hotspots and trends in a field through quantitative and qualitative analyses and has been widely used in numerous areas, such as oncology, endocrinology, and rheumatology [15][16][17][18]. Nevertheless, no prior bibliometric analysis of CMD has been published.…”

Section: Introductionmentioning

confidence: 99%

Global trends and frontiers in research on coronary microvascular dysfunction: a bibliometric analysis from 2002 to 2022

Gao

Meng

et al. 2022

Eur J Med Res

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Background Coronary microvascular dysfunction (CMD) is a leading cause of ischemic heart disease. Over the past few decades, considerable progress has been made with respect to research on CMD. The present study summarized the current research hotspots and trends on CMD by applying a bibliometric approach. Methods Relevant publications between 2002 and 2022 were extracted from the Web of Science Core Collection. Visualization network maps of countries, institutions, authors, and co-cited authors were built using VOSviewer. CiteSpace was used for keyword analysis and the construction of a dual-map overlay of journals and a timeline view of co-cited references. Results 1539 CMD-related publications were extracted for bibliometric analysis. The annual publications generally showed an upward trend. The United States of America was the most prolific country, with 515 publications (33.5%). Camici P. G. was the most influential author, whereas the European Heart Journal, Circulation, and Journal of the American College of Cardiology were the most authoritative journals. Research hotspot analysis revealed that endothelial dysfunction as well as reduced nitric oxide production or bioavailability played critical roles in CMD development. Positron emission tomography was the most widely used imaging method for diagnosis. In addition, microvascular angina, hypertrophic cardiomyopathy, and heart failure have attracted much attention as the main clinical implications. Furthermore, international standards for CMD diagnosis and management may be the future research directions. Conclusions This study offers a comprehensive view about the hotspots and development trends of CMD, which can assist subsequent researchers and guide future directions.

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“…Bibliometric is a method of quantitative analysis, which employs co-keyword and co-citation analysis of previous studies to facilitate the identification of popular themes and emerging trends in all study fields ( 11 , 12 ). Thus, many scholars have performed bibliometric analysis on diseases ( 13 – 16 ), using CiteSpace, VOSviewer, and Bibliographic Items Co-occurrence Matrix Builder (BICOMB) for analysis and visualization ( 17 – 19 ). Nevertheless, there have been no bibliometric studies about BCMP throughout the COVID-19 pandemic.…”

Section: Introductionmentioning

confidence: 99%

Research trends and hotspots of breast cancer management during the COVID-19 pandemic: A bibliometric analysis

Lyu

Tang

et al. 2022

Front. Oncol.

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BackgroundThe coronavirus disease 2019 (COVID-19) pandemic is disrupting routine medical care of cancer patients, including those who have cancer or are undergoing cancer screening. In this study, breast cancer management during the COVID-19 pandemic (BCMP) is reviewed, and the research trends of BCMP are evaluated by quantitative and qualitative evaluation.MethodsIn this study, published studies relating to BCMP from 1 January 2020 to 1 April 2022 were searched from the Web of Science database (WoS). Bibliometric indicators consisted of publications, research hotspots, keywords, authors, journals, institutions, nations, and h-index.ResultsA total of 182 articles investigating BCMP were searched. The United States of America and the University of Rome Tor Vergata were the nation and the institution with the most publications on BCMP. The first three periodicals with leading published BCMP studies were Breast Cancer Research and Treatment, Breast, and In Vivo. Buonomo OC was the most prolific author in this field, publishing nine articles (9/182, 4.94%). The co-keywords analysis of BCMP suggests that the top hotspots and trends in research are screening, surgery, rehabilitation, emotion, diagnosis, treatment, and vaccine management of breast cancer during the pandemic. The hotspot words were divided into six clusters, namely, screening for breast cancer patients in the pandemic, breast cancer surgery in the pandemic, recovery of breast cancer patients in the pandemic, motion effect of the outbreak on breast cancer patients, diagnosis and treatment of breast cancer patients in the pandemic, and vaccination management for breast cancer patients during a pandemic.ConclusionBCMP has received attention from scholars in many nations over the last 3 years. This study revealed significant contributions to BCMP research by nations, institutions, scholars, and journals. The stratified clustering study provided the current status and future trends of BCMP to help physicians with the diagnosis and treatment of breast cancer through the pandemic, and provide a reference for in-depth clinical studies on BCMP.

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Mapping Intellectual Structures and Research Hotspots of Triple Negative Breast Cancer: A Bibliometric Analysis

Cited by 21 publications

References 78 publications

Bioinformatics Method Was Used to Analyze the Highly Expressed Gene FAM83A of Breast Cancer in Young Women

Bioinformatics Method Was Used to Analyze the Highly Expressed Gene FAM83A of Breast Cancer in Young Women

Global trends and frontiers in research on coronary microvascular dysfunction: a bibliometric analysis from 2002 to 2022

Research trends and hotspots of breast cancer management during the COVID-19 pandemic: A bibliometric analysis

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