Mapping in pig of genes involved in sexual differentiation: AMH, WT1 FTZF1, SOX2, SOX9, AHC, and placental and embryonic CYP19

Lahbib-Mansais, Y.; Barbosa, Angela Silva; Yerle, Martine M.; Parma, P.; Milan, Denis; Pailhoux, Eric; Gellin, Joël; Cotinot, Corinne

doi:10.1159/000134525

Cited by 30 publications

(8 citation statements)

References 11 publications

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“…It might thus be possible that AromP450 isozyme, which is distinct from that in the mPOAM and derived from a different gene, is expressed in the young‐to‐adult type of areas. The presence of AromP450 isozymes has already been reported for pigs (Choi et al,1997; Conley et al,1997; Lahbib‐Mansais et al,1997) and fishes (Kitawaki et al,1987; Osawa et al,1987; Callard and Tchoudakova,1997; Tchoudakova and Callard,1998). For the zebra finch, it has been suggested that two types of aromatase in the hypothalamus and telencephalon are distinctive in biochemistry and in hormonal regulation (Balthazart et al,1990).…”

Section: Discussionmentioning

confidence: 76%

Percutaneous biopsy of pediatric solid tumors

Garrett

Fuller

Santana

et al. 2005

Cancer

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The brain has an estrogen‐biosynthetic potential resulting from the presence of neuronal aromatase, which controls the intraneural sex‐steroidal milieu and is involved in brain sexual differentiation, psychobehavioral regulation, and neuroprotection. In the rat brain, three distinct aromatase‐P450‐immunoreactive (AromP450‐I) neural groups have been categorized in terms of their peak expression time (fetal, fetoneonatal, and young‐to‐adult groups), suggesting the presence of region‐specific regulation on brain AromP450. In the present study, we compared the expressions between AromP450 protein and mRNA by using immunohistochemistry and in situ hybridization with an ovary‐derived cRNA probe in serial sections of fetal, fetoneonatal, and adult male rat brains and then performed steroidal manipulations to evaluate the sex‐steroidal effects on AromP450 in adult orchiectomized and adrenalectomized (OCX + ADX) male rats. As a result, prominent mRNA signals were detected in the fetal (i.e., the anterior medial preoptic nucleus) and fetoneonatal (i.e., the medial preopticoamygdaloid neuronal arc) groups, although no detectable signal was found in the “young‐to‐adult” group (i.e., the central amygdaloid nucleus). In addition, the “fetoneonatal” AromP450‐I neurons were prominently reduced in number and intensity after OCX + ADX and then were reinstated by the administration of dihydrotestosterone, testosterone, or 17β‐estradiol. In contrast, none of the sex steroids had any significant effects on the young‐to‐adult group. Several possible explanations were explored for why the young‐to‐adult group may differ in aromatase expression and regulation, including the possibility that distinct splicing variants or isozymes for aromatase exist in the rat brain. J. Comp. Neurol. 500:557–573, 2007. © 2006 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 76%

Percutaneous biopsy of pediatric solid tumors

Garrett

Fuller

Santana

et al. 2005

Cancer

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“…It might thus be possible that AromP450 isozyme, which is distinct from that in the mPOAM and derived from a different gene, is expressed in the young-to-adult type of areas. The presence of AromP450 isozymes has already been reported for pigs (Choi et al, 1997;Conley et al, 1997;Lahbib-Mansais et al, 1997) and fishes Osawa et al, 1987;Callard and Tchoudakova, 1997;Tchoudakova and Callard, 1998). For the zebra finch, it has been suggested that two types of aromatase in the hypothalamus and telencephalon are distinctive in biochemistry and in hormonal regulation (Balthazart et al, 1990).…”

Section: Distinct Characteristics Of Young-to-adult Group Aromatasementioning

confidence: 87%

Region‐specific expression and sex‐steroidal regulation on aromatase and its mRNA in the male rat brain: Immunohistochemical and in situ hybridization analyses

Zhao

Fujinaga

Tanaka

et al. 2006

J of Comparative Neurology

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The brain has an estrogen-biosynthetic potential resulting from the presence of neuronal aromatase, which controls the intraneural sex-steroidal milieu and is involved in brain sexual differentiation, psychobehavioral regulation, and neuroprotection. In the rat brain, three distinct aromatase-P450-immunoreactive (AromP450-I) neural groups have been categorized in terms of their peak expression time (fetal, fetoneonatal, and young-to-adult groups), suggesting the presence of region-specific regulation on brain AromP450. In the present study, we compared the expressions between AromP450 protein and mRNA by using immunohistochemistry and in situ hybridization with an ovary-derived cRNA probe in serial sections of fetal, fetoneonatal, and adult male rat brains and then performed steroidal manipulations to evaluate the sex-steroidal effects on AromP450 in adult orchiectomized and adrenalectomized (OCX + ADX) male rats. As a result, prominent mRNA signals were detected in the fetal (i.e., the anterior medial preoptic nucleus) and fetoneonatal (i.e., the medial preopticoamygdaloid neuronal arc) groups, although no detectable signal was found in the "young-to-adult" group (i.e., the central amygdaloid nucleus). In addition, the "fetoneonatal" AromP450-I neurons were prominently reduced in number and intensity after OCX + ADX and then were reinstated by the administration of dihydrotestosterone, testosterone, or 17beta-estradiol. In contrast, none of the sex steroids had any significant effects on the young-to-adult group. Several possible explanations were explored for why the young-to-adult group may differ in aromatase expression and regulation, including the possibility that distinct splicing variants or isozymes for aromatase exist in the rat brain.

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“…We further analyzed the YB-1 localization in different rat glomerular disease models, including immunologic injury to podocytes (PHN), toxic injury to podocytes (PAN), spontaneous normotensive nephrosclerosis (38), and diabetic Zucker rats. Despite the presence of significant glomerular injury in all of these models, YB-1 remained localized predominantly to cell nuclei within the glomerular, tubulointerstitial, and vascular compartment, comparable to healthy control animals ( Figure 3).…”

Section: Yb-1 Localization In Glomerular Disease Modelsmentioning

confidence: 99%

Y-Box Protein 1 Mediates PDGF-B Effects in Mesangioproliferative Glomerular Disease

Roeyen

Eitner

Martinkus

et al. 2005

Journal of the American Society of Nephrology

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The pivotal role of PDGF-B for mesangioproliferative glomerular disease is well established. Here, Y-box protein-1 (YB-1) was identified as a downstream signaling target of PDGF-B. In healthy kidney cells, YB-1 was located predominantly within the nuclear compartment. Subsequent to PDGF-B infusion and in the course of anti-Thy1.1-induced mesangioproliferative glomerulonephritis, relocalization of YB-1 into the cytoplasm was observed. In experimental models that lack profound mesangial cell proliferation (e.g., Puromycin-nephrosis, passive Heyman nephritis, spontaneous normotensive nephrosclerosis, hyperlipidemic diabetic nephropathy), YB-1 remained nuclear. This translocation coincided with upregulation of YB-1 protein levels within the mesangial compartment. Increased YB-1 expression and subcellular shuttling was dependent on PDGF-B signaling via the mitogen-activated protein kinase pathway because these alterations were prevented by specific PDGF aptamers and the mitogen-activated protein kinase pathway inhibitor U0126. Furthermore, PDGF-B strongly induced YB-1 expression in vitro. This induction was important because RNAi-dependent knockdown of YB-1 abolished the mitogenic PDGF-B effect. Taken together, YB-1 seems to represent a specific and necessary PDGF-B target in mesangioproliferative glomerular disease.

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Mapping in pig of genes involved in sexual differentiation: AMH, WT1 FTZF1, SOX2, SOX9, AHC, and placental and embryonic CYP19

Cited by 30 publications

References 11 publications

Percutaneous biopsy of pediatric solid tumors

Percutaneous biopsy of pediatric solid tumors

Region‐specific expression and sex‐steroidal regulation on aromatase and its mRNA in the male rat brain: Immunohistochemical and in situ hybridization analyses

Y-Box Protein 1 Mediates PDGF-B Effects in Mesangioproliferative Glomerular Disease

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