Mapping Functional Alterations in the CNS With [14C]Deoxyglucose

McCulloch, James

doi:10.1007/978-1-4613-3452-1_8

Cited by 86 publications

(60 citation statements)

References 250 publications

(356 reference statements)

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“…However, nimodipine at an in fusion concentration with marked cerebrovascular effects did not alter the rate of glucose utilisation in any CNS region. In view of the proven utility of [14C]2-DG in mapping functional events in the CNS as they are reflected as local rates of glucose utili- sation (McCulloch, 1982;Sokoloff, 1982), there is little to suggest that nimodipine has other than min imal effects on functional activity in cerebral tissue, at least under the conditions of the present study. In contrast, under the same conditions, nimodipine effected marked increases in CBF in most CNS areas, and the magnitude of the local flow changes that we observed is in general accord with those observed with previous, more global measurements (Harper et aI., 1981;Kazda et aI., 1982;Haws et aI., 1983).…”

Section: Discussionmentioning

confidence: 76%

“…Hitherto, although the direct actions of cal cium antagonists such as nimodipine on the cerebral vasculature have been investigated comprehen sively (Allen and Bahr, 1979;Allen and Banghart, 1979;Edvinsson et aI., 1979;To wart andKazda, 1980, 1982;McCalden and Bevan, 1982;White et aI., 1982;Andersson et aI., 1983;Auer et aI., 1983;Brandt et aI., 1983) and smooth muscle), and there is good evidence to believe that these highly specific binding sites, at least in peripheral tissue, represent the locus of ac tion of calcium antagonists Glossmann et aI., 1982;Bellemann et aI., 1983;Fairhurst et aI., 1983;Glossmann and Ferry, 1983;Holck et aI., 1983;Quirion, 1983). Second, the administration of calcium antagonists can effect overt, though subtle, alterations in behaviour (Hoff meister et aI., 1982), and changes in cerebral func tion are generally manifested as local alterations in cerebral metabolic activity (Sokoloff, 1981(Sokoloff, , 1982McCulloch, 1982). However, nimodipine at an in fusion concentration with marked cerebrovascular effects did not alter the rate of glucose utilisation in any CNS region.…”

Section: Discussionmentioning

confidence: 99%

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Effect of the Calcium Antagonist Nimodipine on Local Cerebral Blood Flow and Metabolic Coupling

Mohamed

Mendelow

Teasdale

et al. 1985

J Cereb Blood Flow Metab

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Summary:The effects of a continuous infusion of the calcium antagonist nimodipine (1 j,Lg kg -1 min -1) on local CBF (LCBF) and local cerebral glucose utilisation (LCGU) were studied, using the quantitative autoradio graphic [14C]iodoantipyrine and [14C]2-deoxyglucose techniques in 34 anatomically discrete regions of the brain in lightly restrained, conscious rats. The infusion of ni modipine at this concentration produced only a small (8%) reduction in the MABP. The administration of ni modipine did not alter the rate of glucose utilisation in any of the regions examined. By contrast, in 24 regions, CBF was increased significantly by 39-84% from control

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Effect of the Calcium Antagonist Nimodipine on Local Cerebral Blood Flow and Metabolic Coupling

Mohamed

Mendelow

Teasdale

et al. 1985

J Cereb Blood Flow Metab

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“…It may be, for example, that the marked effect of neuroleptics on activity of the habenula (McCulloch, 1982;Palacios and Wiederhold, 1985;Room et al, 1991) is necessary for their improvement in attentional performance when administered chronically (Orzack et al, 1967;Spohn and Strauss, 1989). In this case, animals with complete habenula lesions would be a model of patients who are nonresponders to neuroleptics, in respect to their attentional choice accuracy deficit.…”

Section: Discussionmentioning

confidence: 99%

Bilateral Lesions of the Habenula Induce Attentional Disturbances in Rats

Lecourtier

Kelly

2004

Neuropsychopharmacol

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The habenular nuclear complex is a major influence on brainstem cell groups that influence attention, but its role in attentional performance has not previously been explored. The present study investigated how habenula lesions affect attentional function as assessed by the 5-choice serial reaction time task (5-CSRTT) in male Lister-Hooded rats. Rats were pretrained in the 5-CSRTT before receiving discrete bilateral lesions of the habenula or a sham procedure. In test sessions immediately following recovery from surgery, lesioned rats showed a marked increase in premature responding. Over the course of testing this increase of premature responding declined in magnitude. In contrast, choice accuracy showed no impairment during the earliest postsurgery test sessions but progressively deteriorated over the course of testing. These opposite time courses strongly imply that different mechanisms mediate these two effects of the habenula lesion. Differential effects of drug treatment on these effects further supported this view. Thus, D-amphetamine (0.2 mg/ kg s.c.) increased premature responding without affecting choice accuracy. On the other hand, haloperidol (0.01-0.03 mg/kg i.p.) decreased premature responding without significantly affecting choice accuracy. The results are consistent with the view that elevated premature responding in habenula-lesioned animals is mediated by increased dopaminergic activity, whereas impaired choice accuracy is not. Implications of these findings for the hypothesis that habenula dysfunction is involved in cognitive symptoms of schizophrenia are discussed.

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“…One approach to assessment of local brain function is metabolic mapping with 2-deoxyglucose McCulloch 1982;Sokoloff 1983). Because glucose is a major substrate for cerebral energy metabolism (Sokoloff 1977;Siesjb 1978), measurement of the re gional cerebral metabolic rate for glucose (rCMRglc) pro vides an index of local brain function (Sokoloff 1977;Sokoloff 1978).…”

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confidence: 99%

Buprenorphine Reduces Cerebral Glucose Metabolism in Polydrug Abusers

Walsh

Gilson

Jasinski

et al. 1994

Neuropsychopharmacol

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Buprenorphine is a mixed opioid agonist-antagonist, which acts as a partial mu agonist and a kappa antagonist. The present study evaluated the acute effects of buprenorphine on cerebral glucose metabolism (CMRglc) in six human substance abusers using a double-blind, placebo-controlled, counterbalanced, crossover design. Each subject participated in two positron emission tomographic (PET) studies, 1 week apart, following the injection of buprenorphine (1 mg, intramuscularly) and placebo. Buprenorphine significantly reduced CMRglc and the regional cerebral KEY WORDS: Opioid; Buprenorphine; Glucose metabolism; Drug abuse; Human brain imaging Buprenorphine, a semi-synthetic opioid drug derived from thebaine, is currently marketed in the United States as an analgesic, and is approximately 25 to 50 times as potent as morphine (Cowan et al. 1977). In hu man subjects, it produces effects that are typical of opi oid agonists (Heel et al. 1979). These include analge-

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Mapping Functional Alterations in the CNS With [14C]Deoxyglucose

Cited by 86 publications

References 250 publications

Effect of the Calcium Antagonist Nimodipine on Local Cerebral Blood Flow and Metabolic Coupling

Effect of the Calcium Antagonist Nimodipine on Local Cerebral Blood Flow and Metabolic Coupling

Bilateral Lesions of the Habenula Induce Attentional Disturbances in Rats

Buprenorphine Reduces Cerebral Glucose Metabolism in Polydrug Abusers

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